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View Structure Prediction Details

Protein: pde-4
Organism: Caenorhabditis elegans
Length: 612 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for pde-4.

Description E-value Query
Range
Subject
Range
pde-4 - status:Partially_confirmed UniProt:Q2V4U0 protein_id:ABB88209.1
667.0 [0..1] [612..62]

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Predicted Domain #1
Region A:
Residues: [1-134]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNGVARRKQF KLRPWQSTAL PSRHDHYSCA GSATAADGLG GAHLTPSLSS SVHARRESFL  60
   61 YRASDDLREA SSLRPVSRAS SIASNEHGHG DDLIVTPFAQ LLASLRNVRS NLISITNIQN 120
  121 SDDSRHANRS AKRP

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [135-263]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PLHNIELPDD VVHCAHDTLE ELDWCLDQLE TIQTHRSVSE MASSKFRKML NKELSHFAES  60
   61 SKSGTQVSKF LITTYMDKEE DEPSIEIEVP TEVQGPSTSG PMTLSILKKA QTAAMNKISG 120
  121 VRKLRAPSH

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [264-612]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DGHVPEYGVN CAREIAVHMQ RLDDWGPDVF KIDELSKNHS LTVVTFSLLR QRNLFKTFEI  60
   61 HQSTLVTYLL NLEHHYRNNH YHNFIHAADV AQSMHVLLMS PVLTEVFTDL EVLAAIFAGA 120
  121 VHDVDHPGFT NQYLINSNNE LAIMYNDESV LEQHHLAVAF KLLQDSNCDF LANLSRKQRL 180
  181 QFRKIVIDMV LATDMSKHMS LLADLKTMVE AKKVAGNNVI VLDKYNDKIQ VLQSMIHLAD 240
  241 LSNPTKPIEL YQQWNQRIME EYWRQGDKEK ELGLEISPMC DRGNVTIEKS QVGFIDYIVH 300
  301 PLYETWADLV YPDAQNILDQ LEENREWYQS RIPEEPDTAR TVTEDDEHK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 126.0
Match: 1oynA
Description: Catalytic domain of cyclic nucleotide phosphodiesterase pde4d
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
cyclic-nucleotide phosphodiesterase activity 2.9145758096876 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle