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View Structure Prediction Details

Protein: ceh-18
Organism: Caenorhabditis elegans
Length: 540 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ceh-18.

Description E-value Query
Range
Subject
Range
ceh-18 - homeobox protein status:Confirmed UniProt:P41934 protein_id:AAA80426.2
316.0 [0..1] [540..1]

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Predicted Domain #1
Region A:
Residues: [1-72]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNTLENTFQF LAEVFEANGG CLVTERVSPS LSGASKRKSR PVKRIITEDE VIPEEEVVEE  60
   61 EEEEKVEQPS EE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [73-187]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VTCPAMQVDA TDAILASLRQ IANNDLSEHC IREDEGNTSA EVFSNGNGED MEQAGLAGTD  60
   61 LLRRVADMLQ GNHNGSLNSH FLQQQFAAFK VDPTPVSTNG NGLLTPITTQ LSPLF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 12.522879
Match: 1wh6A
Description: Solution structure of the second CUT domain of human Homeobox protein Cux-2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
DNA binding 5.51228466689923 bayes_pls_golite062009
nucleic acid binding 5.37468811865033 bayes_pls_golite062009
transcription regulator activity 5.05236457497789 bayes_pls_golite062009
transcription factor activity 3.89464979825638 bayes_pls_golite062009
binding 3.66501723413351 bayes_pls_golite062009
sequence-specific DNA binding 3.25218945600666 bayes_pls_golite062009
transcription activator activity 3.15886611325686 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.32042014361691 bayes_pls_golite062009
transcription repressor activity 1.75958281319075 bayes_pls_golite062009
protein binding 1.55649304400241 bayes_pls_golite062009
transcription factor binding 1.02788976342343 bayes_pls_golite062009
transcription cofactor activity 0.8718993114781 bayes_pls_golite062009
chromatin binding 0.62573870961765 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.34211447646243 bayes_pls_golite062009
catalytic activity 0.00446472034106909 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [188-284]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TSTDAFNSPE KLLQAIMTPS LGFLGANGLG ASNSGLLSSP LIAPSPTLLQ SLMNTPTQPT  60
   61 ASLTPKKAEN RPPVVSQTLK ASKRRLFDDT SRIEAAS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [285-540]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSGDDRIDMN ELEAFAQTFK KQRIKFGFTQ GDVGVALGKR YGTDFSQTTI SRFEALNLSF  60
   61 KNMCKLRPLL KEWLADVEMA IEGGATVTDL IDKKTIHNGN HHTIHHVDIH ETSISNSISS 120
  121 VTASSLLSRE QHVKRRRKRT NLDMNQRNAL DTFFALNPRP DHDKMTDIAN SLELDRDVVR 180
  181 VWFCNRRQKM RRVDEPIEGE MVTPSVSPVF PHFSSMSALE QIQEAARLAS CQASNDDSDG 240
  241 TSGSPDAPSN DGCSDL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 21.0
Match: 1o4xA
Description: TERNARY COMPLEX OF THE DNA BINDING DOMAINS OF THE OCT1 AND SOX2 TRANSCRIPTION FACTORS WITH A 19MER OLIGONUCLEOTIDE FROM THE HOXB1 REGULATORY ELEMENT
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
DNA binding 5.51228466689923 bayes_pls_golite062009
nucleic acid binding 5.37468811865033 bayes_pls_golite062009
transcription regulator activity 5.05236457497789 bayes_pls_golite062009
transcription factor activity 3.89464979825638 bayes_pls_golite062009
binding 3.66501723413351 bayes_pls_golite062009
sequence-specific DNA binding 3.25218945600666 bayes_pls_golite062009
transcription activator activity 3.15886611325686 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.32042014361691 bayes_pls_golite062009
transcription repressor activity 1.75958281319075 bayes_pls_golite062009
protein binding 1.55649304400241 bayes_pls_golite062009
transcription factor binding 1.02788976342343 bayes_pls_golite062009
transcription cofactor activity 0.8718993114781 bayes_pls_golite062009
chromatin binding 0.62573870961765 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.34211447646243 bayes_pls_golite062009
catalytic activity 0.00446472034106909 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle