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View Structure Prediction Details

Protein: nhr-104
Organism: Caenorhabditis elegans
Length: 242 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for nhr-104.

Description E-value Query
Range
Subject
Range
gi|68396885 - gi|68396885|ref|XP_683221.1| PREDICTED: similar to retinoid X receptor-alpha [Danio rerio]
197.0 [0..1] [242..203]

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Predicted Domain #1
Region A:
Residues: [1-95]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRFNPCDVCL SPGNGKHFGV DACRGCTAFF RRTIVNKRNY SCSEDDTCEI EKSEGLLCKK  60
   61 CRFEKCLKVG MKKESIQKHR DIYGRRNPEN RALII

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 20.09691
Match: 1lo1A
Description: Steroid hormone receptor Err2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.00967542385368 bayes_pls_golite062009
DNA binding 3.60745514727532 bayes_pls_golite062009
nucleic acid binding 3.47256374293954 bayes_pls_golite062009
binding 2.96409924710655 bayes_pls_golite062009
transcription activator activity 2.9532663930699 bayes_pls_golite062009
transcription factor activity 2.90769972671972 bayes_pls_golite062009
sequence-specific DNA binding 2.72967350701574 bayes_pls_golite062009
protein binding 2.44501340584871 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.40923942043513 bayes_pls_golite062009
ligand-dependent nuclear receptor activity 1.49515149729803 bayes_pls_golite062009
transcription factor binding 1.38523780690867 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.26452462867497 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.68943696300126 bayes_pls_golite062009
transcription cofactor activity 0.58115018700114 bayes_pls_golite062009
transcription repressor activity 0.256420113528322 bayes_pls_golite062009
catalytic activity 0.101795606736461 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [96-242]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SPSTSQLQVT IPITLLSSVK RNYAELENVR EIVHRMDGFS MFLKPAPRGQ TYKETYRLLL  60
   61 REFYLVSDWV SNCFPLFKEL PNSQKDILLR NFYLTFYNLE AGFFACQHNK IDVWFLPNGN 120
  121 FIDCQNLEAF YYDPHNQQPM TSADAAR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 19.221849
Match: 1lbdA
Description: LIGAND-BINDING DOMAIN OF THE HUMAN NUCLEAR RECEPTOR RXR-ALPHA
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle