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View Structure Prediction Details

Protein: nhr-101
Organism: Caenorhabditis elegans
Length: 391 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for nhr-101.

Description E-value Query
Range
Subject
Range
gi|73967652 - gi|73967652|ref|XP_548399.2| PREDICTED: similar to Retinoic acid receptor RXR-alpha (Retinoid X rece...
301.0 [0..4] [387..61]

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Predicted Domain #1
Region A:
Residues: [1-84]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQFEELCLVC NDLSSGYHYG VPSCNGCKTF FRRTIMKKQL FVCQHEKNCP VDKSIRCACR  60
   61 FCRFEKCIQV GMDKSALQAS RDRI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 21.69897
Match: 2hanB
Description: No description for 2hanB was found.

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.00967542385368 bayes_pls_golite062009
DNA binding 3.60745514727532 bayes_pls_golite062009
nucleic acid binding 3.47256374293954 bayes_pls_golite062009
binding 2.96409924710655 bayes_pls_golite062009
transcription activator activity 2.9532663930699 bayes_pls_golite062009
transcription factor activity 2.90769972671972 bayes_pls_golite062009
sequence-specific DNA binding 2.72967350701574 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 2.55186574506963 bayes_pls_golite062009
protein binding 2.44501340584871 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.40923942043513 bayes_pls_golite062009
transcription repressor activity 1.88834375049208 bayes_pls_golite062009
ligand-dependent nuclear receptor activity 1.49515149729803 bayes_pls_golite062009
transcription factor binding 1.38523780690867 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.26452462867497 bayes_pls_golite062009
transporter activity 0.768214707487563 bayes_pls_golite062009
structural constituent of ribosome 0.644659911825478 bayes_pls_golite062009
transcription coactivator activity 0.61572149323953 bayes_pls_golite062009
transcription cofactor activity 0.58115018700114 bayes_pls_golite062009
transmembrane transporter activity 0.50876329665586 bayes_pls_golite062009
structural molecule activity 0.441960874303873 bayes_pls_golite062009
receptor activity 0.230063209127305 bayes_pls_golite062009
substrate-specific transporter activity 0.187612502757984 bayes_pls_golite062009
catalytic activity 0.101795606736461 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [85-391]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GYTKRTRKPK TKDVSFSSSS EMSPGSYFAE SPGYAQKAFE TYWSYVVSRE KASNEMRLSD  60
   61 YLPKRSLKEA LCSKSLLNDP IFLSKYALPS SKHTYTSLRF ITQTDYHYWH ERDWFVLTEY 120
  121 AKTFKIFEAL SYADKAELVR HSAITLPALN QVYNSPDHGL DTVVFPDGTY YDRTHEPTRP 180
  181 SGLNRKKYQV LDLVLKPFRE IDINFNEFAA FKAITFLNPD ADVSLQAKLA INEERISVTK 240
  241 QLYDYMVRND GIEKAIKRFS RLILIGTSMS KMACESKEAV WIADFFENIG YTSFAKELFF 300
  301 GDYDSDV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 34.30103
Match: 1z5xE
Description: hemipteran ecdysone receptor ligand-binding domain complexed with ponasterone A
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle