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View Structure Prediction Details

Protein: uaf-1
Organism: Caenorhabditis elegans
Length: 474 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for uaf-1.

Description E-value Query
Range
Subject
Range
gi|73976783 - gi|73976783|ref|XP_857420.1| PREDICTED: similar to Polyadenylate-binding protein 4 (Poly(A)-binding ...
324.0 [0..75] [474..12]

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Predicted Domain #1
Region A:
Residues: [1-150]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDHQDGMKL EDIERQFLDV AQREGGLEAI QPTTGPLENE ENLKSSTGGG GGEDDNDRGE  60
   61 RRGGGGGGDR DRSRSRERRR GGGGRDEPRR RGGDDEARSR REPEPQKPRE PKKYRFWDVP 120
  121 PTGFETTTPM EYKNMQAAGQ VPRGSVQSAV 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [151-267]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PVVGPSVTCQ SRRLYVGNIP FGCNEEAMLD FFNQQMHLCG LAQAPGNPIL LCQINLDKNF  60
   61 AFIEFRSIDE TTAGMAFDGI NFMGQQLKVR RPRDYQPSQN TFDMNSRMPV STIVVDS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 32.69897
Match: 2g4bA
Description: No description for 2g4bA was found.

Predicted Domain #3
Region A:
Residues: [268-368]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ANKIFIGGLP NYLTEDQVKE LLCSFGPLKA FSLNVDSQGN SKGYAFAEYL DPTLTDQAIA  60
   61 GLNGMQLGDK QLVVQLACAN QQRHNTNLPN SASAIAGIDL S

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 16.69897
Match: 2u2fA
Description: Splicing factor U2AF 65 KDa subunit
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 6.73097473547076 bayes_pls_golite062009
6.62953239642182 bayes_pls_golite062009
mRNA binding 5.29759606920196 bayes_pls_golite062009
nucleic acid binding 4.92126426323641 bayes_pls_golite062009
snRNA binding 4.06596327298973 bayes_pls_golite062009
binding 3.64400841800969 bayes_pls_golite062009
poly-pyrimidine tract binding 3.11990160533699 bayes_pls_golite062009
U1 snRNA binding 3.02511982045347 bayes_pls_golite062009
single-stranded RNA binding 2.93798024346416 bayes_pls_golite062009
transcription regulator activity 1.92450390013691 bayes_pls_golite062009
DNA binding 1.8021593476478 bayes_pls_golite062009
structural molecule activity 1.29928829870122 bayes_pls_golite062009
transcription factor activity 1.15127506309683 bayes_pls_golite062009
protein binding 1.12215421354121 bayes_pls_golite062009
mRNA 3'-UTR binding 0.591700155096213 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.425042944899091 bayes_pls_golite062009
transporter activity 0.417047632648771 bayes_pls_golite062009
sequence-specific DNA binding 0.383589644462932 bayes_pls_golite062009
cytoskeletal protein binding 0.288834004308736 bayes_pls_golite062009
transmembrane transporter activity 0.288804044686487 bayes_pls_golite062009
snoRNA binding 0.0568636182001701 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.00171911393626201 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [369-474]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QGAGRATEIL CLMNMVTEDE LKADDEYEEI LEDVRDECSK YGIVRSLEIP RPYEDHPVPG  60
   61 VGKVFVEFAS TSDCQRAQAA LTGRKFANRT VVTSYYDVDK YHNRQF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 13.09691
Match: 1o0pA
Description: Splicing factor U2AF 65 KDa subunit
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 6.73097473547076 bayes_pls_golite062009
6.62953239642182 bayes_pls_golite062009
mRNA binding 5.29759606920196 bayes_pls_golite062009
nucleic acid binding 4.92126426323641 bayes_pls_golite062009
snRNA binding 4.06596327298973 bayes_pls_golite062009
binding 3.64400841800969 bayes_pls_golite062009
poly-pyrimidine tract binding 3.11990160533699 bayes_pls_golite062009
U1 snRNA binding 3.02511982045347 bayes_pls_golite062009
single-stranded RNA binding 2.93798024346416 bayes_pls_golite062009
transcription regulator activity 1.92450390013691 bayes_pls_golite062009
DNA binding 1.8021593476478 bayes_pls_golite062009
structural molecule activity 1.29928829870122 bayes_pls_golite062009
transcription factor activity 1.15127506309683 bayes_pls_golite062009
protein binding 1.12215421354121 bayes_pls_golite062009
mRNA 3'-UTR binding 0.591700155096213 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.425042944899091 bayes_pls_golite062009
transporter activity 0.417047632648771 bayes_pls_golite062009
sequence-specific DNA binding 0.383589644462932 bayes_pls_golite062009
cytoskeletal protein binding 0.288834004308736 bayes_pls_golite062009
transmembrane transporter activity 0.288804044686487 bayes_pls_golite062009
snoRNA binding 0.0568636182001701 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.00171911393626201 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle