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View Structure Prediction Details

Protein: tdc-1
Organism: Caenorhabditis elegans
Length: 705 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for tdc-1.

Description E-value Query
Range
Subject
Range
gi|39587206, gi|... - gi|39587206|emb|CAE57674.1| Hypothetical protein CBG00668 [Caenorhabditis briggsae], gi|187038885|em...
gi|157749819 - gi|157749819|ref|XP_001678623.1| Hypothetical protein CBG00668 [Caenorhabditis briggsae AF16]
585.0 [0..1] [705..1]

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Predicted Domain #1
Region A:
Residues: [1-121]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVYGLGEALK NLNSYCQERT TRIRNSLSPS RPSMSEATAT GSSSSSRAST TIPSTPNMDV  60
   61 TPTVEDPRQN DNNASGMTRD EFRQYGKETV DYIVDYLENI QKRRVVPAIE PGYLKDLIPS 120
  121 E

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 109.0
Match: 1js3A
Description: DOPA decarboxylase
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [122-591]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 APNTPESFES VMEDFEKLIM PGITHWQHPR FHAYFPAGNS FPSIIADMLS DAIGCVGFSW  60
   61 AACPAMTELE LIMLDWFGKM IGLPAEFLPL TENGKGGGVI QSSASECNFV TLLAARFEVM 120
  121 KELRQRFPFV EEGLLLSKLI AYCSKEAHSS VEKACMIGMV KLRILETDSK FRLRGDTLRN 180
  181 AIQEDRNLGL IPFFVSTTLG TTSCCSFDVL SEIGPICKEN ELWLHVDAAY SGSAFICPEF 240
  241 RPLMNGIEYA MSFNTNPNKW LLINFDCSTM WVRDRFKLTQ ALVVDPLYLQ HSWMDKSIDY 300
  301 RHWGIPLSRR FRSLKLWFVI RMYGIDGLQK YIREHVRLAK KMETLLRADA KFEIVNEVIM 360
  361 GLVCFRMKGD DELNQTLLTR LNASGRIHMV PASLGDRFVI RFCVCAENAT DKDIEVAYEI 420
  421 IAQATQHVLH DSVKAVIAEE DEEAVALEEM VADLNITETP EKCLTRQNSA 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 21.0
Match: 1cj0A
Description: Serine hydroxymethyltransferase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
4-aminobutyrate transaminase activity 2.49533238079952 bayes_pls_golite062009
catalytic activity 2.29878871754893 bayes_pls_golite062009
transferase activity, transferring nitrogenous groups 1.28316822767388 bayes_pls_golite062009
transaminase activity 1.24990480711889 bayes_pls_golite062009
5-aminolevulinate synthase activity 1.01853440922526 bayes_pls_golite062009
transferase activity 0.737426388870721 bayes_pls_golite062009
succinate-semialdehyde dehydrogenase binding 0.408430609033885 bayes_pls_golite062009
binding 0.252160165096264 bayes_pls_golite062009
L-aspartate:2-oxoglutarate aminotransferase activity 0.130698724135981 bayes_pls_golite062009
carbon-carbon lyase activity 0.11598778799668 bayes_pls_golite062009
aromatic-L-amino-acid decarboxylase activity 0.10589462882093 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [592-705]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NAAESGQKLE RQLSKEEILA QKQHESLAKK RSFLVRMVSD PKCYNPKIVR HLNMANHRKM  60
   61 SQDLYRDRTL MQTISHSQRP NRLSQSPGSA GSAFFDDDDD RIVADVQTGL QTPI

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


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