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View Structure Prediction Details

Protein: fbl-1
Organism: Caenorhabditis elegans
Length: 712 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for fbl-1.

Description E-value Query
Range
Subject
Range
gi|115658472, gi... - gi|115946065|ref|XP_001193115.1| PREDICTED: similar to fibropellin Ia [Strongylocentrotus purpuratus...
367.0 [0..5] [658..360]

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Predicted Domain #1
Region A:
Residues: [1-183]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRICFLLLAF LVAETFANEL TRCCAGGTRH FKNSNTCSSI KSEGTSMTCQ RAASICCLRS  60
   61 LLDNACDSGT DIAKEEESCP SNINILGGGL KKECCDCCLL AKDLLNRNEP CVAPVGFSAG 120
  121 CLRSFNKCCN GDIEITHASE IITGRPLNDP HVLHLGDRCA SSHCEHLCHD RGGEKVECSC 180
  181 RSG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.30103
Match: 2dtgE
Description: No description for 2dtgE was found.

Predicted functions:

Term Confidence Notes
growth factor binding 4.27465167431259 bayes_pls_golite062009
insulin-like growth factor binding 4.02348040390921 bayes_pls_golite062009
protein binding 3.04595153576805 bayes_pls_golite062009
binding 2.46953677547264 bayes_pls_golite062009
insulin-like growth factor I binding 2.25070305389602 bayes_pls_golite062009
insulin-like growth factor II binding 1.29233483287178 bayes_pls_golite062009
protein tyrosine phosphatase activator activity 0.92638446697292 bayes_pls_golite062009
phosphatase activator activity 0.234175951765568 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [184-520]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FDLAPDGMAC VDIDECATLM DDCLESQRCL NTPGSFKCIR TLSCGTGYAM DSETERCRDV  60
   61 DECNLGSHDC GPLYQCRNTQ GSYRCDAKKC GDGELQNPMT GECTSITCPN GYYPKNGMCN 120
  121 DIDECVTGHN CGAGEECVNT PGSFRCQQKG NLCAHGYEVN GATGFCEDVN ECQQGVCGSM 180
  181 ECINLPGTYK CKCGPGYEFN DAKKRCEDVD ECIKFAGHVC DLSAECINTI GSFECKCKPG 240
  241 FQLASDGRRC EDVNECTTGI AACEQKCVNI PGSYQCICDR GFALGPDGTK CEDIDECSIW 300
  301 AGSGNDLCMG GCINTKGSYL CQCPPGYKIQ PDGRTCV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 16.522879
Match: 1n7dA
Description: Low density lipoprotein (LDL) receptor YWTD domain; Low density lipoprotein (LDL) receptor, different EGF domains; Ligand-binding domain of low-density lipoprotein receptor
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
receptor binding 4.33045214660893 bayes_pls_golite062009
extracellular matrix structural constituent 3.98005075037205 bayes_pls_golite062009
growth factor activity 3.53240291240997 bayes_pls_golite062009
protein binding 3.02592228806142 bayes_pls_golite062009
ErbB-2 class receptor binding 2.42443754640644 bayes_pls_golite062009
binding 2.33940742543305 bayes_pls_golite062009
glycosaminoglycan binding 2.04860930279383 bayes_pls_golite062009
ErbB-3 class receptor binding 1.94863441611642 bayes_pls_golite062009
heparin binding 1.68224847671034 bayes_pls_golite062009
polysaccharide binding 1.52943230565474 bayes_pls_golite062009
pattern binding 1.40261567769805 bayes_pls_golite062009
epidermal growth factor receptor binding 1.07113751916821 bayes_pls_golite062009
carbohydrate binding 0.37481112933019 bayes_pls_golite062009
transcription regulator activity 0.282532662545359 bayes_pls_golite062009
transcription factor binding 0.25804698792789 bayes_pls_golite062009
transcription cofactor activity 0.154111600670615 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [521-712]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DVDECAMGEC AGSDKVCVNT LGSFKCHSID CPTNYIHDSL NKNRCNRQPS ACGLPEECSK  60
   61 VPLFLTYQFI SLARAVPISS HRPAITLFKV SAPNHADTEV NFELQLKTTI VGAPNVLPAI 120
  121 RANFLLQKGE KRNSAVVTLR DSLDGPQTVK LQLLLRMSKK GKNFNTYAAN LIVDVAAHKR 180
  181 HNTVHPPLMK IR

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.21
Match: 1gl4A
Description: Domain G2 of nidogen-1; EGF-like domain of nidogen-1
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle