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View Structure Prediction Details

Protein: cpl-1
Organism: Caenorhabditis elegans
Length: 337 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for cpl-1.

Description E-value Query
Range
Subject
Range
gi|109112413, gi... - gi|109112413|ref|XP_001106814.1| PREDICTED: cathepsin L2 isoform 3 [Macaca mulatta], gi|109112411|re...
357.0 [0..1] [337..1]

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Predicted Domain #1
Region A:
Residues: [1-337]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNRFILLALV AAVVAVNSAK LSRQIESAIE KWDDYKEDFD KEYSESEEQT YMEAFVKNMI  60
   61 HIENHNRDHR LGRKTFEMGL NHIADLPFSQ YRKLNGYRRL FGDSRIKNSS SFLAPFNVQV 120
  121 PDEVDWRDTH LVTDVKNQGM CGSCWAFSAT GALEGQHARK LGQLVSLSEQ NLVDCSTKYG 180
  181 NHGCNGGLMD QAFEYIRDNH GVDTEESYPY KGRDMKCHFN KKTVGADDKG YVDTPEGDEE 240
  241 QLKIAVATQG PISIAIDAGH RSFQLYKKGV YYDEECSSEE LDHGVLLVGY GTDPEHGDYW 300
  301 IVKNSWGAGW GEKGYIRIAR NRNNHCGVAT KASYPLV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 91.0
Match: 1cs8A
Description: (Pro)cathepsin L
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
peptidase activity 4.90619850296986 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 4.64381885397949 bayes_pls_golite062009
endopeptidase activity 3.75054525912786 bayes_pls_golite062009
hydrolase activity 3.74079711298952 bayes_pls_golite062009
cysteine-type peptidase activity 2.71117522993364 bayes_pls_golite062009
cysteine-type endopeptidase activity 1.95802900199539 bayes_pls_golite062009
binding 1.29265216891074 bayes_pls_golite062009
catalytic activity 1.05972260874031 bayes_pls_golite062009
protein binding 0.774177093888744 bayes_pls_golite062009
small conjugating protein-specific protease activity 0.649171767629235 bayes_pls_golite062009
thiolester hydrolase activity 0.59115205419466 bayes_pls_golite062009
kininogen binding 0.41283715939055 bayes_pls_golite062009
signal transducer activity 0.12644030784065 bayes_pls_golite062009
molecular transducer activity 0.12644030784065 bayes_pls_golite062009
ubiquitin-specific protease activity 0.0101379718864654 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle