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View Structure Prediction Details

Protein: unc-115
Organism: Caenorhabditis elegans
Length: 625 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for unc-115.

Description E-value Query
Range
Subject
Range
gi|73947291 - gi|73947291|ref|XP_541354.2| PREDICTED: similar to Zinc finger protein 606 (Zinc finger protein 328)...
528.0 [0..4] [466..2410]

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Predicted Domain #1
Region A:
Residues: [1-181]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGKKCDVCRK KCSGDVLKAN DKYFHINCFQ CKKCGRNLGE TGFYTTPENA YLCPDDFRAV  60
   61 SKEITVKTTT QQAHASSSSA ATPKSPEKSN GTTDVSSSGA ANATLQQISP LGSPTTCAAC 120
  121 DQALHSGQVL LALGLSWHVY CFKCSECSAV LHGEYMSHHG KPLCLRDYNE KFGVKCYECE 180
  181 K

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 48.045757
Match: 2i13A
Description: No description for 2i13A was found.

Predicted Domain #2
Region A:
Residues: [182-224]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FIAGKVLQAG GYKFHPTCAR CSRCGSHFGD GEEMYMQGDE IWH

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.87
Match: 1v6gA
Description: Solution Structure of the LIM Domain of the Human Actin Binding LIM Protein 2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.33031501809283 bayes_pls_golite062009
protein binding 0.484915054040372 bayes_pls_golite062009
transcription regulator activity 0.340288079661743 bayes_pls_golite062009
DNA binding 0.00134487825101615 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [225-326]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PSCEHARTTE NIAPTGRAAT LSRNEPKYQS TFGQHQAYMY LLPEVEQTYL RHPVMNAKEP  60
   61 NAPQYHVPQG PIKIRKSRMS MLKTGMQRLT EDLEKNIPRP KS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 13.69897
Match: 1a1fA
Description: ZIF268
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [327-465]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PHMDNEEPIE LAHYPAAHVP DPDTLPAIER EDFPAPQFPY AVEELKRRLS TSSVENEISD  60
   61 DEYSESDKVD EDKLRKTVET LEKYNDSSIA HVIRQNIEDS HKKQRLPLHW DPRNASRTPS 120
  121 GKKMPHLKFR YDVPINASP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10.0
Match: 2cotA
Description: Solution structure of the first and second zf-C2H2 domain of Zinc finger protein 435
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.5693324142242 bayes_pls_golite062009
transcription regulator activity 1.20084827450202 bayes_pls_golite062009
DNA binding 1.11228868978256 bayes_pls_golite062009
nucleic acid binding 1.10067326005752 bayes_pls_golite062009
transcription factor activity 0.33874886911135 bayes_pls_golite062009
protein binding 0.186544761618633 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [466-544]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SRHLNRPRPW VVWQGGERDQ GNNTLPCFHI PEDSRANTLR AATLPTEFGQ NLSLENLDTT  60
   61 ISSHYSEHST TESGTAGGP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [545-625]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RSAGGAVLRS SLPDMSKPAK QYDLLFLQTT NSDLPEDVDR QHLERHLPRD QFEEIFKMSL  60
   61 IEFYKLPEWK RINLKRKHKL F

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 25.69897
Match: 1ujsA
Description: Solution structure of the Villin headpiece domain of human actin-binding LIM protein homologue (KIAA0843 protein)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 0.890394134199723 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle