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View Structure Prediction Details

Protein: unc-115
Organism: Caenorhabditis elegans
Length: 625 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for unc-115.

Description E-value Query
Range
Subject
Range
gi|73947291 - gi|73947291|ref|XP_541354.2| PREDICTED: similar to Zinc finger protein 606 (Zinc finger protein 328)...
528.0 [0..4] [466..2410]

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Predicted Domain #1
Region A:
Residues: [1-181]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGKKCDVCRK KCSGDVLKAN DKYFHINCFQ CKKCGRNLGE TGFYTTPENA YLCPDDFRAV  60
   61 SKEITVKTTT QQAHASSSSA ATPKSPEKSN GTTDVSSSGA ANATLQQISP LGSPTTCAAC 120
  121 DQALHSGQVL LALGLSWHVY CFKCSECSAV LHGEYMSHHG KPLCLRDYNE KFGVKCYECE 180
  181 K

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 48.045757
Match: 2i13A
Description: No description for 2i13A was found.

Predicted Domain #2
Region A:
Residues: [182-224]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FIAGKVLQAG GYKFHPTCAR CSRCGSHFGD GEEMYMQGDE IWH

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.87
Match: 1v6gA
Description: Solution Structure of the LIM Domain of the Human Actin Binding LIM Protein 2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.33031501809283 bayes_pls_golite062009
protein binding 0.484915054040372 bayes_pls_golite062009
transcription regulator activity 0.340288079661743 bayes_pls_golite062009
DNA binding 0.00134487825101615 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [225-326]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PSCEHARTTE NIAPTGRAAT LSRNEPKYQS TFGQHQAYMY LLPEVEQTYL RHPVMNAKEP  60
   61 NAPQYHVPQG PIKIRKSRMS MLKTGMQRLT EDLEKNIPRP KS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 13.69897
Match: 1a1fA
Description: ZIF268
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [327-465]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PHMDNEEPIE LAHYPAAHVP DPDTLPAIER EDFPAPQFPY AVEELKRRLS TSSVENEISD  60
   61 DEYSESDKVD EDKLRKTVET LEKYNDSSIA HVIRQNIEDS HKKQRLPLHW DPRNASRTPS 120
  121 GKKMPHLKFR YDVPINASP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10.0
Match: 2cotA
Description: Solution structure of the first and second zf-C2H2 domain of Zinc finger protein 435
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.5693324142242 bayes_pls_golite062009
transcription regulator activity 1.20084827450202 bayes_pls_golite062009
DNA binding 1.11228868978256 bayes_pls_golite062009
nucleic acid binding 1.10067326005752 bayes_pls_golite062009
transcription factor activity 0.33874886911135 bayes_pls_golite062009
protein binding 0.186544761618633 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [466-544]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SRHLNRPRPW VVWQGGERDQ GNNTLPCFHI PEDSRANTLR AATLPTEFGQ NLSLENLDTT  60
   61 ISSHYSEHST TESGTAGGP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [545-625]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RSAGGAVLRS SLPDMSKPAK QYDLLFLQTT NSDLPEDVDR QHLERHLPRD QFEEIFKMSL  60
   61 IEFYKLPEWK RINLKRKHKL F

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 25.69897
Match: 1ujsA
Description: Solution structure of the Villin headpiece domain of human actin-binding LIM protein homologue (KIAA0843 protein)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 0.890394134199723 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle