YRC Public Data Repository - Protein Structure Prediction

Protein:	mls-1
Organism:	Caenorhabditis elegans
Length:	252 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for mls-1.

Description	E-value	Query Range	Subject Range
gi\|114612957 - gi\|114612957\|ref\|XP_522453.2\| PREDICTED: similar to T-box 20 isoform a [Pan troglodytes]	341.0	[0..11]	[235..226]
TBX20_CHICK - T-box transcription factor TBX20 OS=Gallus gallus GN=TBX20 PE=2 SV=1	336.0	[0..8]	[235..71]
gi\|73976299 - gi\|73976299\|ref\|XP_539513.2\| PREDICTED: similar to T-box 20 isoform a isoform 1 [Canis familiaris]	332.0	[0..11]	[235..81]
ENSPTRT00000035255 - null gi\|117676399, gi... - gi\|117676399\|ref\|NP_001071121.1\| T-box transcription factor TBX20 [Homo sapiens], gi\|115589803\|gb\|AB...	331.0	[0..11]	[235..80]
gi\|13540369 - gi\|13540369\|gb\|AAK29436.1\| brachyury protein [Eleutherodactylus coqui]	330.0	[0..3]	[249..3]
gi\|149027905, gi... - gi\|149027905\|gb\|EDL83365.1\| T-box 20 (predicted), isoform CRA_d [Rattus norvegicus], gi\|109484407\|re...	330.0	[0..11]	[235..80]
gi\|151555635, gi... - gi\|151555635\|gb\|AAI48729.1\| T-box 20 [synthetic construct], gi\|147898137\|gb\|AAI40332.1\| T-box 20 [sy... TBX20_MOUSE - T-box transcription factor TBX20 OS=Mus musculus GN=Tbx20 PE=2 SV=3	329.0	[0..11]	[235..79]
gi\|76615342 - gi\|76615342\|ref\|XP_587044.2\| PREDICTED: similar to T-box transcription factor TBX20 [Bos taurus]	328.0	[0..11]	[235..82]
TBX20_XENLA - T-box transcription factor TBX20 OS=Xenopus laevis GN=tbx20 PE=2 SV=1	327.0	[0..8]	[235..71]
TBX20_DANRE - T-box transcription factor TBX20 OS=Danio rerio GN=tbx20 PE=2 SV=1	327.0	[0..9]	[235..77]

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Predicted Domain #1

Region A:
Residues: [1-252]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNRNFSIDAI LARKPVEKRK QIITKDNCKF IRVFLQSSNL WRRFHNLGTE MIVTKSGRRM  60
   61 FPTLSVIIAG LDPVKSYVVM VDLECIEMKR FRYSFHQSKW ISTGPGESEL PSRMFVHTDS 120
  121 PARGAHWMRA PVSFDKMKLT NNQLDNNGHI IVNSMHKYRP RVHIIEQDDS QKRHTFSFEE 180
  181 TEFIAVTAYQ NHRITSLKIE SNPFAKGFRE CEVQGIEMNS VGGMTGGPAF QSVFPLIFPY 240
  241 FANLASNMNV NK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	79.09691
Match:	1h6fA
Description:	T-box protein 3, tbx3
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	3.82913410895101	bayes_pls_golite062009
DNA binding	3.66817147088612	bayes_pls_golite062009
transcription regulator activity	3.64801189357929	bayes_pls_golite062009
nucleic acid binding	3.4281783503437	bayes_pls_golite062009
transcription factor activity	3.00834358271623	bayes_pls_golite062009
sequence-specific DNA binding	2.78676291654359	bayes_pls_golite062009
protein binding	2.61625563263605	bayes_pls_golite062009
transcription activator activity	2.550621891551	bayes_pls_golite062009
DNA strand annealing activity	1.17814334604363	bayes_pls_golite062009
RNA polymerase II transcription factor activity	1.03496325074066	bayes_pls_golite062009
double-stranded DNA binding	0.90477390899557	bayes_pls_golite062009
structure-specific DNA binding	0.67715424282347	bayes_pls_golite062009
chromatin binding	0.34201146905158	bayes_pls_golite062009
transcription repressor activity	0.21694638611622	bayes_pls_golite062009
protein dimerization activity	0.0889583851427092	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: