YRC Public Data Repository - Protein Structure Prediction

Protein:	cat-4
Organism:	Caenorhabditis elegans
Length:	223 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for cat-4.

Description	E-value	Query Range	Subject Range
gi\|39593376, gi\|... - gi\|39593376\|emb\|CAE64846.1\| Hypothetical protein CBG09642 [Caenorhabditis briggsae], gi\|187031670\|em... gi\|157763238 - gi\|157763238\|ref\|XP_001673961.1\| Hypothetical protein CBG09642 [Caenorhabditis briggsae AF16]	330.0	[0..1]	[223..1]
gi\|25290301 - pir\|\|AG2466 GTP cyclohydrolase I [imported] - Nostoc sp. (strain PCC 7120) GCH11_NOSS1 - GTP cyclohydrolase 1 1 OS=Nostoc sp. (strain PCC 7120 / UTEX 2576) GN=folE1 PE=3 SV=1	328.0	[0..5]	[223..11]
gi\|75702476, gi\|... - gi\|75908751\|ref\|YP_323047.1\| GTP cyclohydrolase I [Anabaena variabilis ATCC 29413], gi\|75702476\|gb\|A...	328.0	[0..5]	[223..11]
gi\|255061 - gi\|255061\|gb\|AAB23164.1\| GTP cyclohydrolase I [Homo sapiens]	322.0	[0..5]	[221..24]
gi\|46118361, gi\|... - gi\|67925134\|ref\|ZP_00518508.1\| GTP cyclohydrolase I [Crocosphaera watsonii WH 8501], gi\|67853028\|gb\|...	322.0	[0..1]	[223..1]
GCH1_NOSP7 - GTP cyclohydrolase 1 OS=Nostoc punctiforme (strain ATCC 29133 / PCC 73102) GN=folE PE=3 SV=1	322.0	[0..6]	[223..12]
gi\|109083691 - gi\|109083691\|ref\|XP_001087365.1\| PREDICTED: GTP cyclohydrolase 1 (dopa-responsive dystonia) isoform ...	321.0	[0..5]	[221..33]
gi\|73963003 - gi\|73963003\|ref\|XP_851883.1\| PREDICTED: similar to GTP cyclohydrolase I (GTP-CH-I) isoform 1 [Canis ...	320.0	[0..23]	[221..50]
gi\|20150246, gi\|... - gi\|55670748\|pdb\|1WPL\|J Chain J, Crystal Structure Of The Inhibitory Form Of Rat Gtp Cyclohydrolase I...	319.0	[0..5]	[221..13]

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Predicted Domain #1

Region A:
Residues: [1-223]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSRIENESGF LSSDAASVGS EDDKVEMKKR NGTIPKEDHL KSMCNAYQSI IQHVGEDINR  60
   61 QGLLKTPERA AKAMMAFTKG YDDQLDELLN EAVFDEDHDE MVIVKDIEMF SLCEHHLVPF 120
  121 MGKVHIGYIP NKKVLGLSKL ARIVEMFSRR LQVQERLTKQ IATAMVQAVQ PSGVAVVIEA 180
  181 SHMCMVMRGV QKINASTTTS CMLGVFRDDP KTREEFLNLI NKR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	87.522879
Match:	1is7A
Description:	GTP cyclohydrolase I
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
GTP cyclohydrolase I activity	5.27071565931386	bayes_pls_golite062009
cyclohydrolase activity	3.66553359909123	bayes_pls_golite062009
GTP cyclohydrolase activity	3.44912994722205	bayes_pls_golite062009
6-pyruvoyltetrahydropterin synthase activity	2.94513271787536	bayes_pls_golite062009
catalytic activity	2.20788162511962	bayes_pls_golite062009
dihydroneopterin aldolase activity	1.96466418682643	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	1.73101699306211	bayes_pls_golite062009
binding	1.62520629128577	bayes_pls_golite062009
protein binding	1.34873192832825	bayes_pls_golite062009
hydrolase activity	1.10190985324326	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	0.974891318710762	bayes_pls_golite062009
carbon-carbon lyase activity	0.25616855487144	bayes_pls_golite062009
urate oxidase activity	0.0294957696532921	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: