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View Structure Prediction Details

Protein: mug30
Organism: Schizosaccharomyces pombe
Length: 807 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for mug30.

Description E-value Query
Range		 Subject
Range
gi|109460078 - gi|109460078|ref|XP_220050.4| PREDICTED: similar to HECT domain containing 2 [Rattus norvegicus]
 605.0 [0..122] [806..168]
HECTD2 - HECT domain containing 2
 587.0 [0..124] [806..112]
gi|55250203 - gb|AAH86223.1| Unknown (protein for MGC:98711) [Xenopus laevis]
gi|74188723, gi|... - gi|74188723|dbj|BAE28095.1| unnamed protein product [Mus musculus], gi|32451488|ref|NP_080377.2| hec...
 585.0 [0..92] [806..346]
HECD2_PONAB - Probable E3 ubiquitin-protein ligase HECTD2 OS=Pongo abelii GN=HECTD2 PE=2 SV=1
HECD2_PONPY - Probable E3 ubiquitin-protein ligase HECTD2 - Pongo pygmaeus (Orangutan)
 585.0 [0..124] [806..112]
gi|114630756, gi... - gi|114630758|ref|XP_001167783.1| PREDICTED: hect domain and RLD 4 isoform 9 [Pan troglodytes], gi|11...
 579.0 [0..92] [806..346]

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Predicted Domain #1
Region A:
Residues: [1-122] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSRPIEIANV SSGNRRTLPA LHGSSFSSRS ELDNNTNSKI SRRLRELVCQ RMGENPLRLR  60
   61 QSFHETISND SYGNSEKLVI RPCICCNSVL RYPAQAMCFR CSLCMTVNDV YFCLSGSQIK 120
  121 TK

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.06
Match: 1l3eB
Description: CREB-binding transcriptional adaptor protein CBP (p300)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.86664056933527 bayes_pls_golite062009
protein binding 0.519774392649288 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [123-233] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ASTDGSQFIS VEHFVETIHQ TRSALQLAKQ RTGNVQAIVA AGLPLRELIS LVFGSPPILN  60
   61 KLFSVKNGCS IQSSGLNYKL IYQLYHDITN LDILITNELL RAIESLLRRP M

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [234-353] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LYCHDPADYQ YLLILLENPL LNSKSKNIVN KSSSILKRIL GVLSNLNEKT HHFFISCFKK  60
   61 QPYNNPKFFR RKVDLINKFI GQRLMETYSR NKRKHYYNND WQIKSAAITM ALLYSANSQM 120
  121

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

    MCM
Score		 GO
Score		 GO
Term		 SCOP
Match		 SCOP Description
View Download 0.875 0.012 protein ubiquitination a.69.1 C-terminal domain of alpha and beta subunits of F1 ATP synthase

Predicted Domain #4
Region A:
Residues: [354-807] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RLIDRSSFYC IMADFINLYH DFELWEQKIN CFCFCQYPFL LSMGAKISIL QLDARRKMEI  60
   61 KAREAFFSSI LSKMNVEPYL MIRVRRDRLL EDSLRQINDR NKDFRKALKV EFLGEEGIDA 120
  121 GGLKREWLLL LTRKVFSPEF GLFVNCEESS NYLWFNYSHR SKEIDYYHMS GILMGIAIHN 180
  181 SINLDVQMPR AFYKKLLQLP LSFNDLDDFQ PSLYRGLKEL LLFEGDVKNT YGLNFTINLK 240
  241 AVEGFRTVEL KEGGSELSVD NENRKEYVLR YVDYLLNTTV KKQFSAFFDG FMKVCGGNAI 300
  301 SLFQDNEISK LIRGSEEVID WELLKNVCVY DFYDQNAISN SISESEPSMT ASKYLCHSFV 360
  361 SKRKIILWFW DLISHYSLKM QKLFLIFVTG SDRIPATGAH NFQLRISVLG PDSDQLPISH 420
  421 TCFNHLCIWE YSSREKLKKK LDTALLETNG FNIR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 110.0
Match: 1c4zA
Description: Ubiquitin-protein ligase E3a, Hect catalytic domain (E6ap)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ubiquitin-protein ligase activity 7.14616396317218 bayes_pls_golite062009
small conjugating protein ligase activity 6.99796579811325 bayes_pls_golite062009
acid-amino acid ligase activity 6.03005793772151 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 4.50502148129705 bayes_pls_golite062009
sodium channel inhibitor activity 3.64966529121446 bayes_pls_golite062009
proline-rich region binding 3.26053533977534 bayes_pls_golite062009
phosphothreonine binding 2.3451206920409 bayes_pls_golite062009
phosphoserine binding 2.3451206920409 bayes_pls_golite062009
binding 2.32045312021486 bayes_pls_golite062009
ion channel inhibitor activity 2.14402963004533 bayes_pls_golite062009
channel inhibitor activity 2.14402963004533 bayes_pls_golite062009
RNA polymerase binding 1.8762146737407 bayes_pls_golite062009
ligase activity 1.85936914071714 bayes_pls_golite062009
protein binding 1.29390544644063 bayes_pls_golite062009
sodium channel regulator activity 1.19047973745862 bayes_pls_golite062009
catalytic activity 1.15152367676155 bayes_pls_golite062009
transcription factor binding 0.585725073778084 bayes_pls_golite062009
nucleic acid binding 0.509776214744915 bayes_pls_golite062009
transcription regulator activity 0.376852535152545 bayes_pls_golite062009
ubiquitin-ubiquitin ligase activity 0.373649200425601 bayes_pls_golite062009
DNA binding 0.187697131456126 bayes_pls_golite062009
channel regulator activity 0.072778668515899 bayes_pls_golite062009
0.051942165438844 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle