YRC Public Data Repository - Protein Structure Prediction

Protein:	SPBC1685.05
Organism:	Schizosaccharomyces pombe
Length:	997 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

[What does the above image mean?]

[Show Ginzu Version Information]

Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPBC1685.05.

Description	E-value	Query Range	Subject Range
NM111_NEUCR - Pro-apoptotic serine protease nma-111 OS=Neurospora crassa GN=nma-111 PE=3 SV=1 NM111_NEUCR - Pro-apoptotic serine protease nma111 OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708....	456.0	[0..57]	[994..61]
gi\|115390174, gi... - gi\|115390174\|ref\|XP_001212592.1\| conserved hypothetical protein [Aspergillus terreus NIH2624], gi\|11...	453.0	[0..56]	[994..186]
gi\|49096226, gi\|... - gi\|67538532\|ref\|XP_663040.1\| hypothetical protein AN5436.2 [Aspergillus nidulans FGSC A4], ref\|XP_40...	453.0	[0..56]	[993..490]
NM111_CHAGB - Pro-apoptotic serine protease NMA111 OS=Chaetomium globosum GN=NMA111 PE=3 SV=1 NM111_CHAGB - Pro-apoptotic serine protease NMA111 OS=Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 196...	451.0	[0..55]	[995..66]
NM111_ASPFU - Pro-apoptotic serine protease nma111 OS=Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101... NM111_ASPFU - Pro-apoptotic serine protease nma111 OS=Aspergillus fumigatus GN=nma111 PE=3 SV=1	449.0	[0..5]	[991..8]
gi\|39952363, gi\|... - gi\|39952363\|ref\|XP_363898.1\| hypothetical protein MG01824.4 [Magnaporthe grisea 70-15], gb\|EAA56173....	448.0	[0..67]	[994..180]
YIFC_SCHPO - PDZ domain-containing protein C23G3.12c OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SP... SPAC23G3.12c - serine protease	447.0	[0..45]	[994..30]
gi\|46121433, gi\|... - gi\|46121433\|ref\|XP_385271.1\| hypothetical protein FG05095.1 [Gibberella zeae PH-1], gi\|42551314\|gb\|E...	446.0	[0..16]	[992..18]
NM111_ASPOR - Pro-apoptotic serine protease nma111 OS=Aspergillus oryzae (strain ATCC 42149 / RIB 40) GN=nma111 PE... NM111_ASPOR - Pro-apoptotic serine protease nma111 OS=Aspergillus oryzae GN=nma111 PE=3 SV=1	445.0	[0..56]	[994..59]
gi\|90307843, gi\|... - gi\|90307843\|gb\|EAS37474.1\| hypothetical protein CIMG_02828 [Coccidioides immitis RS], gi\|119196907\|r...	437.0	[0..58]	[994..208]

Back

Predicted Domain #1

Region A:
Residues: [1-62]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTPVSSDYRP NHIFLPKFRP DKITSECNTP QQQNVIAEGL YNVSEPFPIR NTDEERYLDT  60
   61 KE

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [63-395]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IHHTWDNTIK NVVRSIVSIK GSALRSFDTE SAGSFCATGF VVNKTLGLIL SNRHVVSPGP  60
   61 ISARASFINY EEIDIYPIYR DPVHDFGFFR YDPSSIRFHD VTEISLSPES AKVGIDIRII 120
  121 GNDAGEKLSI LSSTLARLDR PAPNYGIDNY NDFNTFYYQA ASGTSGGSSG SPVLDISGAA 180
  181 VALNSGGSNS SASSFYLPLD RVVRALRCIE NNTPITRGTL LTEFLHWSYD ELSRIGLPRE 240
  241 FEYDCRTRVP SSTGLLVVSR VLRNSEVSKA LEPGDILIAF KTDSHKSTYI VDFVSLFEVL 300
  301 DEMVGKTIEL HVYRPKRGFL TFQLTVQDLH NVT

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	39.69897
Match:	1y8tA
Description:	Crystal Structure of RV0983 from Mycobacterium tuberculosis- Proteolytically active form
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
peptidase activity	4.29457766519035	bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides	3.89864153190117	bayes_pls_golite062009
endopeptidase activity	3.83715255212076	bayes_pls_golite062009
serine hydrolase activity	3.10188179747851	bayes_pls_golite062009
serine-type peptidase activity	3.09356744910628	bayes_pls_golite062009
hydrolase activity	2.95731933344861	bayes_pls_golite062009
serine-type endopeptidase activity	2.91265669601085	bayes_pls_golite062009
catalytic activity	1.40927913545237	bayes_pls_golite062009
protein binding	1.32810553079123	bayes_pls_golite062009
binding	0.714540979086077	bayes_pls_golite062009
nucleic acid binding	0.51799784310141	bayes_pls_golite062009
protein C-terminus binding	0.285650646146901	bayes_pls_golite062009
DNA binding	0.166098452144962	bayes_pls_golite062009
enzyme binding	0.0323607861080599	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [396-493]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PSRFLEVGGA VLHDLSYQLA RSYQFSLNSG TYVASSGMLN WSSGTRDFLV TRLANKPTPT  60
   61 LDAFIDVLVQ LTDNARVPMH FRVLGKYEEE FTIVTVDR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	6.0
Match:	1p1dA
Description:	Structural Insights into the Inter-domain Chaperoning of Tandem PDZ Domains in Glutamate Receptor Interacting Proteins
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [494-997]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HFFLASIFSR NDEKGTWDRQ SLPPPQPSIS RRPSVIPRPQ EGSKSMEAIQ NALVLVHCRM  60
   61 PYSINGFSST KLYSGTGVIV SVVPPLIVVD RSVIPVDICD IRLTFQSMSA MGHLTFLDNR 120
  121 IAVVSCDYLP SNSVQLNFVA DFLRTGDECT LAALDEDLQL LTKKTTVRSV SVVETERSSP 180
  181 PRFRYVNCEV ISLMDSLAST GGLVFREVGD DREIVALWIS VVHQDVGGKD YTTKYGLSMS 240
  241 YILPVLERLK LPPSARAQHV PTTAGVEWSH ITLAGASTLG LSQTRSSEFY MKSRENGTIP 300
  301 RPLYVISHLR PLLHKTSLGV GDILLEVNGK MITRLSDLHE FETESEIKAV ILRDGIEMEI 360
  361 TIPLYPEYPT FSSRAICWMG AIIHPTHSSV FEQVEPDVDL PGPEGVYVGS ILYGSPALNM 420
  421 LRAAHWIVAV DGHDINTFDD FYHMLLEKPT DTFVQVKQMN RRGATSIVSV RPDPLFWPTC 480
  481 IIERDSNGRW CTKHLQRKTK EVCS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	73.522879
Match:	1ky9A
Description:	Protease Do (DegP, HtrA), C-terminal domains; Protease Do (DegP, HtrA), catalytic domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
peptidase activity	4.29457766519035	bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides	3.89864153190117	bayes_pls_golite062009
endopeptidase activity	3.83715255212076	bayes_pls_golite062009
serine hydrolase activity	3.10188179747851	bayes_pls_golite062009
serine-type peptidase activity	3.09356744910628	bayes_pls_golite062009
hydrolase activity	2.95731933344861	bayes_pls_golite062009
serine-type endopeptidase activity	2.91265669601085	bayes_pls_golite062009
catalytic activity	1.40927913545237	bayes_pls_golite062009
protein binding	1.32810553079123	bayes_pls_golite062009
binding	0.714540979086077	bayes_pls_golite062009
nucleic acid binding	0.51799784310141	bayes_pls_golite062009
protein C-terminus binding	0.285650646146901	bayes_pls_golite062009
DNA binding	0.166098452144962	bayes_pls_golite062009
enzyme binding	0.0323607861080599	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: