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View Structure Prediction Details

Protein: ucp8
Organism: Schizosaccharomyces pombe
Length: 884 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ucp8.

Description E-value Query
Range		 Subject
Range
gi|68388302 - gi|68388302|ref|XP_696268.1| PREDICTED: similar to slow myosin heavy chain 1 [Danio rerio]
 290.0 [0..332] [881..1769]
gi|109123809 - gi|109123809|ref|XP_001113811.1| PREDICTED: similar to epidermal growth factor receptor pathway subs...
 278.0 [0..14] [585..124]
gi|76621154 - gi|76621154|ref|XP_876634.1| PREDICTED: similar to epidermal growth factor receptor pathway substrat...
 273.0 [0..1] [585..6]
EPS15L1 - epidermal growth factor receptor pathway substrate 15-like 1
 272.0 [0..14] [585..19]
gi|73986258 - gi|73986258|ref|XP_541965.2| PREDICTED: similar to epidermal growth factor receptor pathway substrat...
 256.0 [0..1] [585..6]

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Predicted Domain #1
Region A:
Residues: [1-83] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQPLQLSPIE QQEFDRLLES LHPEQKDLIP GSVIGPFLLK FGLPQKILAK IWDYCDQEDK  60
   61 GSLDRNQVYA CFRLISQAQR GAT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 29.0
Match: 1iq3A
Description: Pob1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
actin binding 3.96919556235483 bayes_pls_golite062009
cytoskeletal protein binding 3.49668552859347 bayes_pls_golite062009
structural constituent of muscle 3.12414907235012 bayes_pls_golite062009
microfilament motor activity 2.9702957313812 bayes_pls_golite062009
binding 2.59835122922082 bayes_pls_golite062009
motor activity 2.57627414053278 bayes_pls_golite062009
actin filament binding 2.35534489389161 bayes_pls_golite062009
myosin binding 2.34125070430971 bayes_pls_golite062009
actin-dependent ATPase activity 2.06646671333275 bayes_pls_golite062009
calcium ion binding 1.75413488311654 bayes_pls_golite062009
protein binding 1.36984860219682 bayes_pls_golite062009
metal ion binding 1.19984728454368 bayes_pls_golite062009
cation binding 1.19984728454368 bayes_pls_golite062009
ion binding 1.1923653453763 bayes_pls_golite062009
actin monomer binding 0.9954841049256 bayes_pls_golite062009
tubulin binding 0.710693016758742 bayes_pls_golite062009
myosin heavy chain binding 0.61866037435065 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.401233649632102 bayes_pls_golite062009
pyrophosphatase activity 0.341013054040087 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.32485782650283 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.324368071436317 bayes_pls_golite062009
microtubule binding 0.278596514315141 bayes_pls_golite062009
structural molecule activity 0.234626449126289 bayes_pls_golite062009
structural constituent of cytoskeleton 0.116648335890738 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [84-271] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LQELDYNKAG DPPILPKQAK DDHHIKRSSS ETADFTPFRI PINPDERSEY EKEFRENLRG  60
   61 HEDSARPGCM PSSIAKPILL KSSLHYAVLA QIWNLADSAH VGYLEMYQYV IARHLVAICK 120
  121 QYNLIHLPRS LPADVIESAK SETPAMNTNI EQGVTQPSLV NTEQLSHQQS ISSTKSSKLD 180
  181 EISADNNA

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 3.62
Match: 2qptA
Description: No description for 2qptA was found.

Predicted Domain #3
Region A:
Residues: [272-749] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QSAVDNKYSS PPQTIDPQAN IKALITPEDR SNFYQLFSKI DNENKGYIVG GEAVPFFMAS  60
   61 HLDSEELARI WDTVDTQDRG YIDKDEFAVA MEIIKLRLSG KSLASILAYD DNPTEPTMQQ 120
  121 NLVSDDTNAS TAVPVAFTND NVSNVPLSVA DNEPNSTLNL LASSDTAAFE PTAVSLHENP 180
  181 SSSLEDLQSA FQNTSFQDQV STQNQANTAD ISQNTESGSS TQGQMFGIPP TTQSIPLKMA 240
  241 GFPGGVNSSL TDIKEEEAVS ENAPQQEERS FEQIKTSIHI APENISAIEE SKSVPLPTSF 300
  301 ATTIPGSTSA ALDDQQTTEA PFEEPDEPAH EPTEEEQEEM RKLEEKIEST KYGLETIQTS 360
  361 GKTIKQRIEQ KKTRLMILRE ELQELDAIKE EAQKQISQSL IADQQLSTQI GSVGMGKKQA 420
  421 VKELRKLQAK IDSIIADSMS PMGTGAVNSP AIKPQVTPAP PTPAPTPAVK HHPPPPPV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 29.522879
Match: 1i84S
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [750-884] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RSSISPSMPP APLTHANSST PMNYVSQPES PPQSYESIQN DNELLQELLS MGFPREKAVI  60
   61 ALEATNYDVN EVSDSDSKLS CSKYMCSFTF IYSDFTSNIT NNYRPRIYYL AQFSVCENQS 120
  121 IMTFRLQPFH VIYEL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 6.69897
Match: 2i1jA
Description: No description for 2i1jA was found.
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