YRC Public Data Repository - Protein Structure Prediction

Protein:	SPAC56E4.03
Organism:	Schizosaccharomyces pombe
Length:	474 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPAC56E4.03.

Description	E-value	Query Range	Subject Range
gi\|6429227 - gi\|6429227\|dbj\|BAA86884.1\| multiple substrate aminotransferase (MsAT) [Thermococcus profundus]	277.0	[0..1]	[473..8]
gi\|66360375 - gi\|66360375\|pdb\|1X0M\|A Chain A, A Human Kynurenine Aminotransferase Ii Homologue From Pyrococcus Hor... gi\|66360375\|pdb\|... - Chain A, A Human Kynurenine Aminotransferase Ii Homologue From Pyrococcus Horikoshii Ot3	275.0	[0..7]	[473..4]
gi\|3256593, gi\|1... - gi\|3256593\|dbj\|BAA29276.1\| 428aa long hypothetical protein [Pyrococcus horikoshii OT3], gi\|14590140\|... gi\|7444909 - pir\|\|E71243 probable valine-pyruvate transaminase (EC 2.6.1.66) PH0207 [similarity] - Pyrococcus hor...	275.0	[0..7]	[473..29]
gi\|18976493, gi\|... - gi\|18976493\|ref\|NP_577850.1\| putative aspartate aminotransferase [Pyrococcus furiosus DSM 3638], gi\|...	275.0	[0..5]	[472..13]
gi\|196253921, gi... - gi\|196253921\|ref\|ZP_03152522.1\| aminotransferase class I and II [Clostridium thermocellum DSM 4150],... gi\|67849411, gi\|... - gi\|67916633\|ref\|ZP_00510335.1\| Aminotransferase, class I and II [Clostridium thermocellum ATCC 27405...	274.0	[0..12]	[468..3]
gi\|57640121, gi\|... - gi\|57640121\|ref\|YP_182599.1\| multiple substrate aminotransferase [Thermococcus kodakarensis KOD1], g...	273.0	[0..1]	[473..9]
AAT1_BACSU - Aspartate aminotransferase OS=Bacillus subtilis GN=aspB PE=3 SV=1 AAT1_BACSU - Aspartate aminotransferase OS=Bacillus subtilis (strain 168) GN=aspB PE=3 SV=1 gi\|221314475 - gi\|221314475\|ref\|ZP_03596280.1\| aspartate aminotransferase [Bacillus subtilis subsp. subtilis str. N... gi\|221319397 - gi\|221319397\|ref\|ZP_03600691.1\| aspartate aminotransferase [Bacillus subtilis subsp. subtilis str. J... gi\|221323673 - gi\|221323673\|ref\|ZP_03604967.1\| aspartate aminotransferase [Bacillus subtilis subsp. subtilis str. S...	272.0	[0..12]	[471..3]
gi\|228859394, gi... - gi\|228900225\|ref\|ZP_04064456.1\| Aspartate aminotransferase [Bacillus thuringiensis IBL 4222], gi\|228... gi\|75760397, gi\|... - gi\|75760397\|ref\|ZP_00740441.1\| Aspartate aminotransferase [Bacillus thuringiensis serovar israelensi...	272.0	[0..12]	[469..3]
gi\|228656558, gi... - gi\|229126958\|ref\|ZP_04255969.1\| Aspartate aminotransferase [Bacillus cereus BDRD-Cer4], gi\|228656558... gi\|29895237, gi\|... - gi\|30019693\|ref\|NP_831324.1\| aspartate aminotransferase [Bacillus cereus ATCC 14579], gi\|29895237\|gb...	270.0	[0..12]	[469..3]

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Predicted Domain #1

Region A:
Residues: [1-474]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAQPKDLSH HLSVESASRK QSPLKAVALS KSSRNIKIIS LAGGLPNPEY FPIREMDAEI  60
   61 PAINSWKKDS SNSGKLDTVS VPMSSSDSDV LPLSVALQYG QGSGAALLSQ FLKEHTRIIH 120
  121 NPPYEGWNII MTTGNTSCLD IALRMLTNRG DSILVEKYSF PSALQSMRPL GLSCIPIDMD 180
  181 QFGFLPESMD DILTNWDATS YGSPKPHVLY TIPTGQNPTG STLSVERRKQ IYTLAQKHDI 240
  241 IILEDEPYYY LQMDAYEGKP EAADKAFTNE QFVKELIPSF LSMDVDGRVI RMDSLSKVVA 300
  301 PGSRVGWFTA QPLFIERGLR AAETATQSAS GISQGILYAM FKHWGQDGYL EWLKHIRYSY 360
  361 TLRRNYLLYA MDTYLPKSVC SYIPPVAGMF IWFEVDKSRY IHADKNESIP EIESKIHAEA 420
  421 VEEGVNLACG NWFVVDPRVN DKIFFRVTFA HAELEEFNVA IERFAGVLKN NFKC

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	73.69897
Match:	1x0mA
Description:	a Human Kynurenine Aminotransferase II Homologue from Pyrococcus horikoshii OT3
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
4-aminobutyrate transaminase activity	2.50008459801306	bayes_pls_golite062009
catalytic activity	2.29878871754893	bayes_pls_golite062009
transcription regulator activity	1.67701710033155	bayes_pls_golite062009
glycine dehydrogenase (decarboxylating) activity	1.63055151623667	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor	1.63055151623667	bayes_pls_golite062009
DNA binding	1.4774443071095	bayes_pls_golite062009
transferase activity	1.44093490824786	bayes_pls_golite062009
nucleic acid binding	1.39741122443159	bayes_pls_golite062009
transferase activity, transferring nitrogenous groups	1.28316822767388	bayes_pls_golite062009
kynureninase activity	1.27354164393136	bayes_pls_golite062009
transaminase activity	1.24990480711889	bayes_pls_golite062009
transcription factor activity	1.15775909410582	bayes_pls_golite062009
binding	1.09053123792737	bayes_pls_golite062009
hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances	0.942545094747784	bayes_pls_golite062009
hydrolase activity, acting on acid carbon-carbon bonds	0.845816961387768	bayes_pls_golite062009
L-aspartate:2-oxoglutarate aminotransferase activity	0.619695949258279	bayes_pls_golite062009
5-aminolevulinate synthase activity	0.54326874956263	bayes_pls_golite062009
structural molecule activity	0.347975812448725	bayes_pls_golite062009
pyridoxal phosphate binding	0.16957228630576	bayes_pls_golite062009
vitamin B6 binding	0.16957228630576	bayes_pls_golite062009
aromatic-amino-acid:2-oxoglutarate aminotransferase activity	0.0916183433120769	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: