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View Structure Prediction Details

Protein: taf12
Organism: Schizosaccharomyces pombe
Length: 450 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for taf12.

Description E-value Query
Range
Subject
Range
IGA2_HAEIF - Immunoglobulin A1 protease autotransporter OS=Haemophilus influenzae GN=iga PE=3 SV=1
164.0 [0..2] [439..1008]
tr|M3WQ01|M3WQ01... - TATA-box binding protein associated factor 12 OS=Felis catus GN=TAF12 PE=4 SV=1
ENSCJAT00000018889 - null
gi|109000147, gi... - gi|109000150|ref|XP_001113189.1| PREDICTED: TAF12 RNA polymerase II, TATA box binding protein (TBP)-...
tr|G3H1Y6|G3H1Y6... - Transcription initiation factor TFIID subunit 12 OS=Cricetulus griseus GN=I79_004179 PE=4 SV=1
gi|114555130, gi... - gi|114555130|ref|XP_513257.2| PREDICTED: hypothetical protein isoform 3 [Pan troglodytes], gi|114555...
gi|73950083, gi|... - gi|73966013|ref|XP_851093.1| PREDICTED: similar to Transcription initiation factor TFIID subunit 12 ...
CCDS326.1_1 - null
135.0 [0..291] [443..6]
gi|12841601 - gi|12841601|dbj|BAB25276.1| unnamed protein product [Mus musculus]
134.0 [0..291] [442..6]
gi|70876557 - gi|70876557|gb|EAN89996.1| hypothetical protein, conserved [Trypanosoma cruzi]
gi|71421620 - gi|71421620|ref|XP_811847.1| hypothetical protein [Trypanosoma cruzi strain CL Brener]
132.0 [0..4] [370..128]

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Predicted Domain #1
Region A:
Residues: [1-154]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNGQHSSPGT PVQRPSAGPV NQAQFSQQRT NQLTSLLHTM TMYQQLAQNV GLNTPQGQVY  60
   61 LLQAQTIRRQ LQGHAQSGQL PNQQLLQQLQ SNGALQQGTP EPSNTRPRPQ LNAQEQTMLL 120
  121 VRHRQLQTAQ NYLTEMKEAL GRIKNELSTN ERLD

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [155-346]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TSAREALVKQ ESELTVKIAQ FTAAISNGIR SIQQLQNRQA SSANGNNTGT STPVNASTDT  60
   61 RKSTASTPQL QQTQAQANAP QQRINPETSS VPETPVGVSA ANVSNESTEL ATSATQQSGL 120
  121 ANNVEKSQTP SYMSANHLPK VDSKSPIPFS VPPSRATLTG GYASGSIGLS TPGLSRAPHY 180
  181 ELDNGNRLLS KR

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [347-450]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KLHDLLQQID SEEKIEPEVE ELLLEIADEF VESVTNFACR LAKHRKSDTL DVRDVQLHLE  60
   61 RNWNIRLPGF ASDDIVKSAR KTGPTPSYQQ KQNAIGTAKS LNKD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 24.221849
Match: 1h3oB
Description: TAF(II)-20, (TAF(II)-15, hTAF12), histone fold domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
general RNA polymerase II transcription factor activity 9.25279783093877 bayes_pls_golite062009
lysine N-acetyltransferase activity 5.97252613675094 bayes_pls_golite062009
histone acetyltransferase activity 5.97252613675094 bayes_pls_golite062009
N-acetyltransferase activity 4.49886535711761 bayes_pls_golite062009
DNA binding 4.24625687315724 bayes_pls_golite062009
N-acyltransferase activity 4.22222466548509 bayes_pls_golite062009
transcription regulator activity 4.08606081850613 bayes_pls_golite062009
transcription initiation factor activity 3.96621818094279 bayes_pls_golite062009
nucleic acid binding 3.93473976418251 bayes_pls_golite062009
acetyltransferase activity 3.91614625961398 bayes_pls_golite062009
binding 3.79827182235984 bayes_pls_golite062009
acyltransferase activity 3.38611688546892 bayes_pls_golite062009
transferase activity, transferring acyl groups other than amino-acyl groups 3.35015681315177 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.28941584139552 bayes_pls_golite062009
transferase activity, transferring acyl groups 3.1782337747057 bayes_pls_golite062009
transcription factor activity 2.31114764804139 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.82448881874976 bayes_pls_golite062009
protein binding 1.2861218811362 bayes_pls_golite062009
transcription activator activity 1.25487495162413 bayes_pls_golite062009
transcription factor binding 1.15204005455906 bayes_pls_golite062009
transcription coactivator activity 1.1297723528047 bayes_pls_golite062009
nucleotidyltransferase activity 1.10331930589736 bayes_pls_golite062009
centromeric DNA binding 1.03586371237592 bayes_pls_golite062009
transcription cofactor activity 1.01502031330902 bayes_pls_golite062009
transcription repressor activity 0.72554769377984 bayes_pls_golite062009
histone binding 0.218942897869955 bayes_pls_golite062009

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