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View Structure Prediction Details

Protein: ndc80
Organism: Schizosaccharomyces pombe
Length: 624 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ndc80.

Description E-value Query
Range
Subject
Range
MYH4_PIG - Myosin-4 OS=Sus scrofa GN=MYH4 PE=2 SV=1
191.0 [0..96] [624..992]
MYH4_MOUSE - Myosin-4 OS=Mus musculus GN=Myh4 PE=2 SV=1
188.0 [0..96] [624..994]
MYH4_RAT - Myosin-4 OS=Rattus norvegicus GN=Myh4 PE=1 SV=1
188.0 [0..97] [624..995]
MYH4_RABIT - Myosin-4 OS=Oryctolagus cuniculus GN=MYH4 PE=1 SV=1
187.0 [0..84] [624..981]
MYH4_CANLF - Myosin-4 OS=Canis lupus familiaris GN=MYH4 PE=3 SV=1
186.0 [0..84] [624..982]
gi|50757621 - gi|50757621|ref|XP_415581.1| PREDICTED: similar to fast myosin heavy chain isoform 3 [Gallus gallus]
186.0 [0..97] [624..1096]
gi|109113267 - gi|109113267|ref|XP_001113700.1| PREDICTED: myosin, heavy polypeptide 8, skeletal muscle, perinatal ...
186.0 [0..84] [624..981]

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Predicted Domain #1
Region A:
Residues: [1-388]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQDSSSYARR YSQAPSSSNL RTTTFGFNGL GTSRTSLAPQ RTLVNARQSI DPDGLSSRVL  60
   61 TPTMRPSLAP NTRRSSVRVS NASFISQTPN ITSIKDPRPL SDRRYQQECA TQVVNYLLES 120
  121 GFSQPLGLNN RFMPSTREFA AIFKHLYNKL DPNFRFGARY EEDVTTCLKA LNYPFLDSIS 180
  181 RSRLVAIGSP HVWPAILGML HWVVSLIQCT EKAVAMVYTV EQNSLDDHLV DKVLFDYLVR 240
  241 TYHLYLDESP EESEPEKELK ATFNQQNQDL YNQTEALKST NEELINQIKS AEELDSAIQV 300
  301 LEERYRTMQR DEVKFQSAMS GMKSKMESRT NLMKQLQVNI EEKESQLQLL KEKRDSLKYQ 360
  361 VENQDISISE FEKMVSEREQ LDRNLNMI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 18.30103
Match: 1i84S
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [389-466]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GSKISELRKE VFDTDLLIQA SIDSLEKKVQ KFNSLAYRIG IVPIAAIRSA NNDFELEINP  60
   61 EGPNYINLDL KNKVRPFI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10.30103
Match: 1c1gA
Description: Tropomyosin
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [467-624]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NEVRRSITLE FHEEQNKSLK LQEHVDTVND LIAELQDELR GIESRLTSVL SECNMLRETA  60
   61 SEEKNAFDAE SDKLERELQQ LKLSSHNSML QLDQRIQSIN IEADQIAHAC MEYKNNIYKE 120
  121 VAFVLGEIIH FKLHVQDSLE DLKMDYQKEL DDLSRSEL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 6.39794
Match: 2iw5A
Description: No description for 2iw5A was found.

Predicted functions:

Term Confidence Notes
transcription regulator activity 3.3573497204506 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
DNA binding 3.0205295442286 bayes_pls_golite062009
nucleic acid binding 2.77547609431902 bayes_pls_golite062009
transcription factor activity 2.57014522504183 bayes_pls_golite062009
cytoskeletal protein binding 2.1457670954804 bayes_pls_golite062009
chromatin binding 1.68308196781423 bayes_pls_golite062009
actin binding 1.48871115327078 bayes_pls_golite062009
sequence-specific DNA binding 1.41102023549536 bayes_pls_golite062009
centromeric DNA binding 1.13545283098583 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.06075239560835 bayes_pls_golite062009
transcription repressor activity 0.86319868225781 bayes_pls_golite062009
protein binding 0.830419844171551 bayes_pls_golite062009
transcription activator activity 0.68518521953823 bayes_pls_golite062009
DNA-dependent ATPase activity 0.526073636025138 bayes_pls_golite062009
transcription factor binding 0.45727836611098 bayes_pls_golite062009
telomeric DNA binding 0.284650049512347 bayes_pls_golite062009
actin filament binding 0.26311995282891 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.08523661344413 bayes_pls_golite062009
histone binding 0.0391625783266718 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle