YRC Public Data Repository - Protein Structure Prediction

Protein:	vma5
Organism:	Schizosaccharomyces pombe
Length:	394 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for vma5.

Description	E-value	Query Range	Subject Range
VTC1A_DANRE - V-type proton ATPase subunit C 1-A OS=Danio rerio GN=atp6v1c1a PE=2 SV=1	570.0	[0..3]	[394..1]
VATC1_XENTR - V-type proton ATPase subunit C 1 OS=Xenopus tropicalis GN=atp6v1c1 PE=2 SV=1	569.0	[0..3]	[394..1]
VATC1_XENLA - V-type proton ATPase subunit C 1 OS=Xenopus laevis GN=atp6v1c1 PE=2 SV=1	568.0	[0..3]	[394..1]
VATC_MANSE - V-type proton ATPase subunit C OS=Manduca sexta PE=2 SV=1	566.0	[0..3]	[393..1]
VATC1_BOVIN - V-type proton ATPase subunit C 1 OS=Bos taurus GN=ATP6V1C1 PE=1 SV=3	564.0	[0..3]	[394..1]
gi\|57095276, gi\|... - gi\|73974252\|ref\|XP_859004.1\| PREDICTED: similar to Vacuolar ATP synthase subunit C (V-ATPase C subun...	564.0	[0..3]	[394..1]
VATC1_MOUSE - V-type proton ATPase subunit C 1 OS=Mus musculus GN=Atp6v1c1 PE=1 SV=4	563.0	[0..3]	[394..1]
gi\|109087159 - gi\|109087159\|ref\|XP_001084086.1\| PREDICTED: ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 ... gi\|190691657, gi... - gi\|190691657\|gb\|ACE87603.1\| ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 protein [synthet... VATC1_PONAB - V-type proton ATPase subunit C 1 OS=Pongo abelii GN=ATP6V1C1 PE=2 SV=1 gi\|55726675 - gi\|55726675\|emb\|CAH90100.1\| hypothetical protein [Pongo abelii] CCDS6296.1_1 - null VATC1_MACFA - V-type proton ATPase subunit C 1 OS=Macaca fascicularis GN=ATP6V1C1 PE=2 SV=1 gi\|114621191, gi... - gi\|114621193\|ref\|XP_001155379.1\| PREDICTED: ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 ... ATP6V1C1 - ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1	563.0	[0..3]	[394..1]
gi\|50731811 - gi\|50731811\|ref\|XP_418370.1\| PREDICTED: similar to Vacuolar ATP synthase subunit C (V-ATPase C subun...	563.0	[0..3]	[394..1]

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Predicted Domain #1

Region A:
Residues: [1-394]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKSDFWILS VPSRGGSNAD LCDDIERLLV SGSTSLISTV APFDVPPFKV ESLDVLISQS  60
   61 EQLTKQDAQC ASAISKISDI IKNTVSSSSG DLKDYFMVQD KSPLEYVSSF AWNSSRFHMN 120
  121 KTISEISDRI TSEIISFEND IRTRQTSFQQ ASSAFQNMQK KQSGNLSQKS LANIVHEEDV 180
  181 VHGSDYLTNV FIAVPLNLEK QFLNSYETLT DLVIPRSAKK LDQDSEFVLY TVVVFKKTAD 240
  241 SFITKAREAK YTIREFTFEQ GLRETEQSEF DDAAVKEKRM LSSLLRYASI AFSESFQGWI 300
  301 HLKCLCVYVE SILRYGLPPD FSSVIFQPMA KSEVKIKNIL LSKYAYLAQN PVGNNKVKNV 360
  361 DSSAGLDESM ADLNLDEEYL PFVLFTVPSK VFNY

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	137.0
Match:	1u7lA
Description:	Crystal Structure of subunit C (vma5p) of the yeast V-ATPase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
hydrogen ion transmembrane transporter activity	12.3352255617459	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	10.5863459521035	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	9.47957751673845	bayes_pls_golite062009
proton-transporting ATPase activity, rotational mechanism	8.04670314838796	bayes_pls_golite062009
hydrogen-exporting ATPase activity, phosphorylative mechanism	7.25165353297621	bayes_pls_golite062009
cation-transporting ATPase activity	5.95289483482599	bayes_pls_golite062009
cation transmembrane transporter activity	5.74889738890923	bayes_pls_golite062009
ion transmembrane transporter activity	5.64669396672268	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	5.22844923180027	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions	4.07961473146848	bayes_pls_golite062009
transporter activity	3.46526113720851	bayes_pls_golite062009
transmembrane transporter activity	3.37048202892137	bayes_pls_golite062009
substrate-specific transporter activity	3.36986693191031	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism	3.01531981010483	bayes_pls_golite062009
primary active transmembrane transporter activity	2.60440013485447	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	2.60069637398921	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	2.58215499145116	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances	2.57906484106374	bayes_pls_golite062009
ATPase activity, coupled to movement of substances	2.57862595121731	bayes_pls_golite062009
active transmembrane transporter activity	2.50524643368579	bayes_pls_golite062009
hydrolase activity	2.11429056985835	bayes_pls_golite062009
ATPase activity, coupled	1.96367406225153	bayes_pls_golite062009
nucleoside-triphosphatase activity	1.76379885224229	bayes_pls_golite062009
pyrophosphatase activity	1.69566510056354	bayes_pls_golite062009
ATPase activity	1.69439936736892	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	1.67811565012269	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	1.67577649087358	bayes_pls_golite062009
binding	1.5759873319504	bayes_pls_golite062009
catalytic activity	0.902495165806215	bayes_pls_golite062009
protein binding	0.458389541110755	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: