YRC Public Data Repository - Protein Structure Prediction

Protein:	cct8
Organism:	Schizosaccharomyces pombe
Length:	546 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for cct8.

Description	E-value	Query Range	Subject Range
THSB_AERPE - Thermosome subunit beta OS=Aeropyrum pernix GN=thsB PE=3 SV=2 THSB_AERPE - Thermosome subunit beta OS=Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138...	503.0	[0..6]	[528..11]
gi\|7441909 - gi\|7441909\|pir\|\|C72512 probable thermosome, subunit APE2072 - Aeropyrum pernix (strain K1) gi\|5105771, gi\|1... - gi\|5105771\|dbj\|BAA81083.1\| 555aa long hypothetical thermosome, subunit [Aeropyrum pernix K1], gi\|146...	501.0	[0..6]	[528..18]
THSB_THEK1 - Thermosome subunit beta OS=Thermococcus sp. (strain KS-1) GN=thsB PE=3 SV=2 THSB_THEK1 - Thermosome subunit beta OS=Thermococcus sp. (strain JCM 11816 / KS-1) GN=thsB PE=3 SV=2	500.0	[0..1]	[544..1]
THSB_PYRKO - Thermosome subunit beta OS=Pyrococcus kodakaraensis GN=thsB PE=3 SV=1 THSB_THEKO - Thermosome subunit beta OS=Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) GN=ths... gi\|473965, gi\|21... - gi\|473965\|dbj\|BAA06143.1\| heat-shock protein [Pyrococcus sp.], pir\|\|S61294 heat-shock protein - Pyro...	500.0	[0..1]	[544..1]
gi\|18978346, gi\|... - gi\|18978346\|ref\|NP_579703.1\| thermosome, single subunit [Pyrococcus furiosus DSM 3638], gi\|18894178\|...	498.0	[0..1]	[530..1]
THSA_ARCFU - Thermosome subunit alpha OS=Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 ... THSA_ARCFU - Thermosome subunit alpha OS=Archaeoglobus fulgidus GN=thsA PE=3 SV=1	496.0	[0..7]	[529..5]
gi\|2129425 - gi\|2129425\|pir\|\|JC4270 hyperthermophilic heat shock protein - Desulfurococcus mobilis gi\|1168091 - gi\|1168091\|gb\|AAB35235.1\| hyperthermophilic heat shock protein; HHSP [Desulfurococcus] THS_DESSY - Thermosome subunit OS=Desulfurococcus sp. (strain SY) GN=ths PE=3 SV=1	495.0	[0..1]	[543..1]
gi\|30908966 - gi\|30908966\|gb\|AAP37564.1\| thermosome alpha subunit [Thermococcus litoralis]	495.0	[0..1]	[528..1]
THS_METKA - Thermosome subunit OS=Methanopyrus kandleri GN=ths PE=3 SV=1 THS_METKA - Thermosome subunit OS=Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938) GN=ths...	494.0	[0..1]	[529..1]

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Predicted Domain #1

Region A:
Residues: [1-546]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALRVPKASG PQLFREGYRI MQGVEDAVIR NCNAIRELSE ITRTSLGPNG KNKIVVNHLQ  60
   61 QTFLTNDAAT IIRELEVIHP AAKLVVDATQ QQENELGDAA NFVVVFTGEL LAKAENMIRM 120
  121 GLTPLEIAKG YEMALSHTME VLEEICADKI ETVESEKELI KAIRTCISSK QYGNEDFLSD 180
  181 LVAKAILTVL PKDPSKFNVD NIRVVKIMGS SLYNSQVVKG MVFPREPEGT VTRSKEAKVA 240
  241 VFSCPLDISQ TETKGTVLLH NAQEMLDFSK GEENLIESHI KEIYDAGVRV VVTSGNVNDL 300
  301 VLHYLNRFEI LVIRVPSKFE LRRLCRVVGA TPLARMGVPM PEEMGSVDVV ETIEIGGDRV 360
  361 TVFRQVEDIT RTATIVLRGA TKTYLDDLER AIDDGVNIVK ALVKDNRLIF GAGASDMQLC 420
  421 IRLISVGEKT PGIYQHAIKQ YGEAFEVVPR TISENAGLDP TDVISKLYAA HHKENGESIG 480
  481 VDVECENDGT LDAKEAGIFD VLLAKKSAIR LATETVLTVL NVDQVVMSKP AGGPKPPGPN 540
  541 PHWDDD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	139.0
Match:	1q3rA
Description:	Crystal structure of the chaperonin from Thermococcus strain KS-1 (nucleotide-free form of single mutant)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
unfolded protein binding	9.9038451294995	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	3.6934849790316	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	3.40373598585301	bayes_pls_golite062009
hydrogen ion transmembrane transporter activity	3.28982639907979	bayes_pls_golite062009
binding	3.11215702001989	bayes_pls_golite062009
protein binding	2.03574683256805	bayes_pls_golite062009
nucleoside-triphosphatase activity	1.88769858570433	bayes_pls_golite062009
ATPase activity	1.85640607183492	bayes_pls_golite062009
pyrophosphatase activity	1.81343301131567	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	1.79412354283105	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	1.79183933227438	bayes_pls_golite062009
nucleic acid binding	1.67284737458957	bayes_pls_golite062009
DNA binding	1.60256620441721	bayes_pls_golite062009
transporter activity	1.27879339110564	bayes_pls_golite062009
transmembrane transporter activity	1.08697283907212	bayes_pls_golite062009
chaperone binding	0.91200031047441	bayes_pls_golite062009
substrate-specific transporter activity	0.828920415160435	bayes_pls_golite062009
hydrolase activity	0.577900060851977	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.573106450426516	bayes_pls_golite062009
ATPase activity, coupled	0.527748436977659	bayes_pls_golite062009
ion transmembrane transporter activity	0.280310103153739	bayes_pls_golite062009
active transmembrane transporter activity	0.275534581026027	bayes_pls_golite062009
hydrogen-exporting ATPase activity, phosphorylative mechanism	0.26275673855778	bayes_pls_golite062009
primary active transmembrane transporter activity	0.252704226951294	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	0.243984617084631	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	0.205808843369749	bayes_pls_golite062009
ATPase activity, coupled to movement of substances	0.202279803135899	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances	0.20198255686005	bayes_pls_golite062009
transferase activity	0.18639662517366	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.16424934648837	bayes_pls_golite062009
catalytic activity	0.107125378994589	bayes_pls_golite062009
kinase activity	0.0871496920547826	bayes_pls_golite062009
cation transmembrane transporter activity	0.0778814959589007	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: