YRC Public Data Repository - Protein Structure Prediction

Protein:	cct5
Organism:	Schizosaccharomyces pombe
Length:	546 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for cct5.

Description	E-value	Query Range	Subject Range
gi\|49650109 - gi\|49650109\|emb\|CAG79835.1\| YALI0E21692p [Yarrowia lipolytica] gi\|49650109, gi\|... - gi\|50553658\|ref\|XP_504240.1\| YALI0E21692p [Yarrowia lipolytica], gi\|49650109\|emb\|CAG79835.1\| unnamed...	544.0	[0..1]	[537..9]
gi\|60302774, gi\|... - gi\|60302774\|ref\|NP_001012581.1\| chaperonin containing TCP1, subunit 5 (epsilon) [Gallus gallus], gi\|...	543.0	[0..4]	[543..2]
gi\|45361527, gi\|... - gi\|45361527\|ref\|NP_989340.1\| chaperonin containing TCP1, subunit 5 (epsilon) [Xenopus (Silurana) tro...	540.0	[0..4]	[543..2]
gi\|238883623 - gi\|238883623\|gb\|EEQ47261.1\| T-complex protein 1 subunit epsilon [Candida albicans WO-1] orf19.9828, orf1... - orf19.2288 CGDID:CAL0006383 Assembly 19, Contig19-10143 (98547, 100193) CDS, translated using codon ... gi\|46436410, gi\|... - gi\|68482613\|ref\|XP_714815.1\| potential cytosolic chaperonin CCT ring complex subunit Cct5 [Candida a...	540.0	[0..1]	[542..8]
gi\|27924333, gi\|... - gi\|27924333\|gb\|AAH44997.1\| Cct5-prov protein [Xenopus laevis], gi\|148237440\|ref\|NP_001080453.1\| chap...	538.0	[0..4]	[543..2]
gi\|119193821, gi... - gi\|90306300\|gb\|EAS35931.1\| T-complex protein 1, epsilon subunit [Coccidioides immitis RS], gi\|119193... gi\|240105558 - gi\|240105558\|gb\|EER23751.1\| T-complex protein 1, epsilon subunit, putative [Coccidioides posadasii C...	537.0	[0..3]	[545..6]
gi\|58257644 - gi\|58257644\|dbj\|BAA07894.2\| KIAA0098 protein [Homo sapiens]	536.0	[0..1]	[543..13]
gi\|18978346, gi\|... - gi\|18978346\|ref\|NP_579703.1\| thermosome, single subunit [Pyrococcus furiosus DSM 3638], gi\|18894178\|...	536.0	[0..10]	[540..1]
gi\|49641281 - gi\|49641281\|emb\|CAH02542.1\| KLLA0B13882p [Kluyveromyces lactis] gi\|49641281, gi\|... - gi\|50304399\|ref\|XP_452149.1\| unnamed protein product [Kluyveromyces lactis], gi\|49641281\|emb\|CAH0254...	535.0	[0..1]	[542..5]
THSB_AERPE - Thermosome subunit beta OS=Aeropyrum pernix GN=thsB PE=3 SV=2 THSB_AERPE - Thermosome subunit beta OS=Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138...	535.0	[0..10]	[538..8]

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Predicted Domain #1

Region A:
Residues: [1-546]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAGLDNAVMV RDDQGNPFIL VRDQEKKRRL HGIDAVKSHI LATKTVANIV RTSLGPRGLD  60
   61 KILISPDGEI TVTNDGATIL DQMEVEHQIA KLLVQLSKSQ DDEIGDGTTG VVVLAGALLE 120
  121 QAEALIDKGI HPIRIADGYE KACQVAVKHL DAISDVVDFS PENTTNLFRS AKTSLGSKVV 180
  181 SKAHDHFANI AVDAVLSVAD LQRKDVDFEL IKVDGKVGGS VDDTKLVKGV VVDKDMSHPQ 240
  241 MPHRIENAKI AILTCPFEPP KPKTKHKLDI TSVSEFEALQ AYEKEKFQEM IKHVKDAGAN 300
  301 LVICQWGFDD EANHLLLQNN LPAVRWVGGP EIELIAIATN GRIVPRFEDL SSDKLGSAGI 360
  361 VREVSFGTTR DKILVIEKCA NSRAVTVFVR GSNKMIVDEA KRALHDALCV VRNLIRDNRV 420
  421 VYGGGAAEIS CSLAVTKEAE KIPGIDQYSM GAFADALDTI PLALAENSGL SSIEALTAVK 480
  481 ARHVKENKAY LGIDCLQTGS NDMRKQFVID PLIGKKQQLL LATQLCRMVL KVNDIIVAGS 540
  541 KDDDYN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	149.0
Match:	1q3sA
Description:	Crystal structure of the chaperonin from Thermococcus strain KS-1 (FormIII crystal complexed with ADP)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
unfolded protein binding	7.60116801069598	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	3.6934849790316	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	3.40373598585301	bayes_pls_golite062009
hydrogen ion transmembrane transporter activity	3.28982639907979	bayes_pls_golite062009
binding	2.07154556649829	bayes_pls_golite062009
nucleic acid binding	1.67284737458957	bayes_pls_golite062009
DNA binding	1.60256620441721	bayes_pls_golite062009
transporter activity	1.27879339110564	bayes_pls_golite062009
transmembrane transporter activity	1.08697283907212	bayes_pls_golite062009
chaperone binding	0.91200031047441	bayes_pls_golite062009
substrate-specific transporter activity	0.828920415160435	bayes_pls_golite062009
ATPase activity, coupled	0.787685249362834	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.75018875403424	bayes_pls_golite062009
pyrophosphatase activity	0.69634667457441	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	0.682843768728088	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	0.680378643689288	bayes_pls_golite062009
protein binding	0.634982583867058	bayes_pls_golite062009
ATPase activity	0.584574936611857	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.573106450426516	bayes_pls_golite062009
catalytic activity	0.424959044318554	bayes_pls_golite062009
ion transmembrane transporter activity	0.280310103153739	bayes_pls_golite062009
active transmembrane transporter activity	0.275534581026027	bayes_pls_golite062009
hydrogen-exporting ATPase activity, phosphorylative mechanism	0.26275673855778	bayes_pls_golite062009
primary active transmembrane transporter activity	0.252704226951294	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	0.243984617084631	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	0.205808843369749	bayes_pls_golite062009
ATPase activity, coupled to movement of substances	0.202279803135899	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances	0.20198255686005	bayes_pls_golite062009
transferase activity	0.18639662517366	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.16424934648837	bayes_pls_golite062009
kinase activity	0.0871496920547826	bayes_pls_golite062009
cation transmembrane transporter activity	0.0778814959589007	bayes_pls_golite062009
hydrolase activity	0.0491351110520448	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: