YRC Public Data Repository - Protein Structure Prediction

Protein:	cct2
Organism:	Schizosaccharomyces pombe
Length:	527 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for cct2.

Description	E-value	Query Range	Subject Range
TCPH_CHICK - T-complex protein 1 subunit eta OS=Gallus gallus GN=CCT7 PE=1 SV=1	536.0	[0..1]	[522..1]
gi\|47215719 - gi\|47215719\|emb\|CAG05730.1\| unnamed protein product [Tetraodon nigroviridis]	536.0	[0..1]	[522..1]
CH602_RHILO - 60 kDa chaperonin 2 OS=Rhizobium loti (strain MAFF303099) GN=groL2 PE=3 SV=1 CH62_RHILO, CH60... - (Q98IH9) 60 kDa chaperonin 2 (Protein Cpn60 2) (groEL protein 2), 60 kDa chaperonin 2 OS=Rhizobium l...	535.0	[0..12]	[527..3]
gi\|18978346, gi\|... - gi\|18978346\|ref\|NP_579703.1\| thermosome, single subunit [Pyrococcus furiosus DSM 3638], gi\|18894178\|...	535.0	[0..1]	[521..4]
gi\|45829538 - gi\|45829538\|gb\|AAH68214.1\| Cct7 protein [Xenopus tropicalis]	535.0	[0..1]	[522..30]
CH603_SINMW - 60 kDa chaperonin 3 OS=Sinorhizobium medicae (strain WSM419) GN=groL3 PE=3 SV=1	534.0	[0..12]	[524..3]
CH60_NEIMF - 60 kDa chaperonin OS=Neisseria meningitidis serogroup C / serotype 2a (strain ATCC 700532 / DSM 1546... gi\|11277961 - pir\|\|H81964 chaperonin 60kD subunit NMA0473 [imported] - Neisseria meningitidis (strain Z2491 serogr... CH60_NEIMA - 60 kDa chaperonin OS=Neisseria meningitidis serogroup A GN=groL PE=3 SV=1 CH60_NEIMA - 60 kDa chaperonin OS=Neisseria meningitidis serogroup A / serotype 4A (strain Z2491) GN=groL PE=3 SV...	534.0	[0..12]	[527..3]
gi\|27769226 - gi\|27769226\|gb\|AAH42312.1\| LOC495278 protein [Xenopus laevis]	533.0	[0..1]	[522..19]
gi\|74191272 - gi\|74191272\|dbj\|BAE39463.1\| unnamed protein product [Mus musculus]	533.0	[0..1]	[522..1]
CH602_CHESB - 60 kDa chaperonin 2 OS=Chelativorans sp. (strain BNC1) GN=groL2 PE=3 SV=1	533.0	[0..12]	[527..3]

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Predicted Domain #1

Region A:
Residues: [1-527]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLNPHQIFN ESGIQERGEN ARLSSFVGAI AVGDLVKSTL GPKGMDKILQ SNSSGDIVVT  60
   61 NDGATILKSI ALDNAAAKVL VNISKVQDDE VGDGTTSVCV FAAELLRQAE IMVNAKIHPQ 120
  121 VIIDGYRIAT KTAIDALRAS SIDNSSDPAK FRSDLENIAR TTLSSKILSQ NKNHFAQLAV 180
  181 DAVLRLKGST NLDNIQIIKI LGGKLDDSFL DEGFILNKTI GVNCPKVMEN ANILIANTAM 240
  241 DTDKVKVFGA RVRVDTTGKL AELERAEREK MKAKVEKIKS HNINCFINRQ LIYNWPEQLF 300
  301 ADAGIMSIEH ADFDGIERLS LVTGGEIAST FDHPELVKLG HCKKIEEIII GEDKMIKFSG 360
  361 VEAGEACTIV LRGATHQLLD ESERAIHDAL AVLSQTVAES RVTLGGGCAE MLMAKAVEEA 420
  421 ATHEPGKKAV AVSAFAKALS QLPTILADNA GFDSSELVAQ LKAAHYDGND TMGLDMDEGE 480
  481 IADMRAKGIL EALKLKQAVV SSGSEGAQLL LRVDTILKAA PRPRERM

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	145.0
Match:	1q3rA
Description:	Crystal structure of the chaperonin from Thermococcus strain KS-1 (nucleotide-free form of single mutant)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
unfolded protein binding	9.9038451294995	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	3.6934849790316	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	3.40373598585301	bayes_pls_golite062009
hydrogen ion transmembrane transporter activity	3.28982639907979	bayes_pls_golite062009
binding	3.11215702001989	bayes_pls_golite062009
protein binding	2.03574683256805	bayes_pls_golite062009
nucleoside-triphosphatase activity	1.88769858570433	bayes_pls_golite062009
ATPase activity	1.85640607183492	bayes_pls_golite062009
pyrophosphatase activity	1.81343301131567	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	1.79412354283105	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	1.79183933227438	bayes_pls_golite062009
nucleic acid binding	1.67284737458957	bayes_pls_golite062009
DNA binding	1.60256620441721	bayes_pls_golite062009
transporter activity	1.27879339110564	bayes_pls_golite062009
transmembrane transporter activity	1.08697283907212	bayes_pls_golite062009
chaperone binding	0.91200031047441	bayes_pls_golite062009
substrate-specific transporter activity	0.828920415160435	bayes_pls_golite062009
hydrolase activity	0.577900060851977	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.573106450426516	bayes_pls_golite062009
ATPase activity, coupled	0.527748436977659	bayes_pls_golite062009
ion transmembrane transporter activity	0.280310103153739	bayes_pls_golite062009
active transmembrane transporter activity	0.275534581026027	bayes_pls_golite062009
hydrogen-exporting ATPase activity, phosphorylative mechanism	0.26275673855778	bayes_pls_golite062009
primary active transmembrane transporter activity	0.252704226951294	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	0.243984617084631	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	0.205808843369749	bayes_pls_golite062009
ATPase activity, coupled to movement of substances	0.202279803135899	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances	0.20198255686005	bayes_pls_golite062009
transferase activity	0.18639662517366	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.16424934648837	bayes_pls_golite062009
catalytic activity	0.107125378994589	bayes_pls_golite062009
kinase activity	0.0871496920547826	bayes_pls_golite062009
cation transmembrane transporter activity	0.0778814959589007	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: