YRC Public Data Repository - Protein Structure Prediction

Protein:	prp10
Organism:	Schizosaccharomyces pombe
Length:	1188 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for prp10.

Description	E-value	Query Range	Subject Range
gi\|49089964, gi\|... - gi\|67523929\|ref\|XP_660024.1\| hypothetical protein AN2420.2 [Aspergillus nidulans FGSC A4], ref\|XP_40...	906.0	[0..1]	[1188..1]
gi\|85111669 - gi\|85111669\|ref\|XP_964047.1\| U2 snRNP component prp10 [Neurospora crassa OR74A] gi\|32419571, gi\|... - gi\|32419571\|ref\|XP_330229.1\| hypothetical protein [Neurospora crassa], gi\|28925808\|gb\|EAA34811.1\| U2...	904.0	[0..1]	[1188..1]
gi\|39974995, gi\|... - gi\|39974995\|ref\|XP_368888.1\| conserved hypothetical protein [Magnaporthe grisea 70-15], gb\|EAA48698....	894.0	[0..1]	[1188..1]
gi\|46125347, gi\|... - gi\|46125347\|ref\|XP_387227.1\| hypothetical protein FG07051.1 [Gibberella zeae PH-1], gi\|42553767\|gb\|E...	893.0	[0..1]	[1188..1]
gi\|116192495, gi... - gi\|88181878\|gb\|EAQ89346.1\| conserved hypothetical protein [Chaetomium globosum CBS 148.51], gi\|11619...	876.0	[0..1]	[1188..1]
gi\|169774443 - gi\|169774443\|ref\|XP_001821689.1\| hypothetical protein [Aspergillus oryzae RIB40] gi\|83769552 - gi\|83769552\|dbj\|BAE59687.1\| unnamed protein product [Aspergillus oryzae] gi\|238497013, gi... - gi\|238497013\|ref\|XP_002379742.1\| splicing factor 3B subunit 1, putative [Aspergillus flavus NRRL3357...	869.0	[0..1]	[1188..1]
gi\|115384360, gi... - gi\|115384360\|ref\|XP_001208727.1\| splicing factor 3B subunit 1 [Aspergillus terreus NIH2624], gi\|1141...	866.0	[0..1]	[1188..1]
gi\|159129768 - gi\|159129768\|gb\|EDP54882.1\| splicing factor 3B subunit 1, putative [Aspergillus fumigatus A1163] gi\|71002060, gi\|... - gi\|71002060\|ref\|XP_755711.1\| splicing factor 3B subunit 1 [Aspergillus fumigatus Af293], gi\|66853349...	858.0	[0..2]	[1188..19]
gi\|119189211, gi... - gi\|90303998\|gb\|EAS33629.1\| conserved hypothetical protein [Coccidioides immitis RS], gi\|119189211\|re...	852.0	[0..1]	[1188..1]
gi\|119115231, gi... - gi\|119115231\|ref\|XP_310958.3\| ENSANGP00000019328 [Anopheles gambiae str. PEST], gi\|116130736\|gb\|EAA0... AGAP000178-PA - splicing factor 3B subunit 1\|protein_coding\|X:2987173:2991824:1\|gene:AGAP000178	836.0	[0..3]	[1186..7]

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Predicted Domain #1

Region A:
Residues: [1-166]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTVEDVEIE RLRAERELLR RQKEAAKNSS TNGSVNIEGT QDSNDLQYNA HLFKSSNPKE  60
   61 EYDSAIDVRN DISQDEDDYK RTNDVNDSYR LVRQYEAPKE LLNEYADESY DPMQERQSKK 120
  121 QIQDRESDYQ KQRYDRQLTP TRVDAFQPDG TQSNGRSYAE VMRQVE

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.281	0.126	U2 snRNP	a.77.1	DEATH domain
View	Download	0.200	0.084	U2 snRNP	d.109.1	Actin depolymerizing proteins
View	Download	0.213	0.032	U2 snRNP	d.110.4	SNARE-like
View	Download	0.213	0.013	U2 snRNP	d.43.1	Elongation factor Ts (EF-Ts), dimerisation domain
View	Download	0.207	0.006	U2 snRNP	b.54.1	Core binding factor beta, CBF

Predicted Domain #2

Region A:
Residues: [167-306]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LEKEERRVHM ELNQRRREGT LKEVEEEESI SDKKRELELN NTEISQKPKR SRWDQAPPSV  60
   61 TQVSTTKRRS RWDKAPENFT ISEHVIENGI SEDLINKEVN VVEEKLRPPV RLLTEEELNE 120
  121 LLPSEGYAIL EPPPGYLESI

[Run NCBI BLAST on this sequence.]

Detection Method:	Pfam
Confidence:	5.187087
Match:	PF08920.1
Description:	No description for PF08920.1 was found.

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [307-363]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HPELLQKGTT LDTYHVPQEQ ELPLEKELPA ALPTEIPGVG DLAFFKQEDV KYFGKLL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	42.0
Match:	1qgkA
Description:	Importin beta
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [364-1188]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KVEDEAKLTI AELRERKILR LLLKVKNGTP PMRKSALRQL TDQARDFGAA ALFNQILPLL  60
   61 MERTLEDQER HLLVKVIDRI LYKLDDLVRP FTHKILVVIE PLLIDEDYYA RAEGREIISN 120
  121 LAKASGLAHM IATMRPDIDH VDEYVRNTTA RAFSVVASAL GVPALLPFLK AVCRSKKSWQ 180
  181 ARHTGVRIIQ QIALLLGCSI LPHLKNLVDC IGHGLEDEQQ KVRIMTALSL SALAEAATPY 240
  241 GIEAFDSVLK PLWSGVQRHR GKSLAAFLKA TGFIIPLMEP EYASHFTRRI MKILLREFNS 300
  301 PDEEMKKIVL KVVSQCASTD GVTPEYLRTD VLPEFFHCFW SRRMASDRRS YKQVVETTVV 360
  361 LAQQVGSRQI VERVVNNFKD ESEPYRKMTA ETVDKVIGSL GVSEIDERLE ELLLDGVLFA 420
  421 FQEQSVEEKV ILTCFSTVVN ALGTRCKPYL PQIVSTILYR LNNKSANVRE QAADLVSSIT 480
  481 IVLKACGEEA LMRKLGVVLY EYLGEEYPEV LGSILGAIKA IVSVVGMSSM QPPIRDLLPR 540
  541 LTPILRNRHE KVQENTIDLV GKIADRGSEY VSAREWMRIC FELIDMLKAH KKSIRRAAVN 600
  601 TFGYISKAIG PQDVLATLLN NLKVQERQNR VCTTVAIAIV AETCMPFTVV PALMADYRTP 660
  661 EMNVQNGVLK SLAFMFEYIG EQARDYVYAI TPLLADALMD RDAVHRQTAA SVIKHLSLGC 720
  721 VGLGVEDAMI HLLNILWPNI LEESPHVINA VREGIDGIRN CIGVGPIMAY LVQGLFHPSR 780
  781 KVRNTYWTSY NSAYVQSADA MVPYYPHVDD DQFNNYDMKT LHICI

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	74.30103
Match:	1qbkB
Description:	Karyopherin beta2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
RNA binding	4.20683443264388	bayes_pls_golite062009
binding	2.91891696274037	bayes_pls_golite062009
mRNA binding	2.49094746544717	bayes_pls_golite062009
protein binding	1.75981610748679	bayes_pls_golite062009
nucleic acid binding	1.64539435934931	bayes_pls_golite062009
structural molecule activity	1.39201458088376	bayes_pls_golite062009
transcription regulator activity	1.06250847754412	bayes_pls_golite062009
DNA binding	0.946847037737779	bayes_pls_golite062009
RNA cap binding	0.66277586901495	bayes_pls_golite062009
transcription factor activity	0.362911773502049	bayes_pls_golite062009
signal sequence binding	0.289133192719901	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: