YRC Public Data Repository - Protein Structure Prediction

Protein:	rpn502, rpn501
Organism:	Schizosaccharomyces pombe
Length:	443 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for rpn502, rpn501.

Description	E-value	Query Range	Subject Range
gi\|42415501, gi\|... - gi\|42415501\|ref\|NP_963872.1\| proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 [Danio reri...	348.0	[0..3]	[438..14]
gi\|73965259 - gi\|73965259\|ref\|XP_537584.2\| PREDICTED: similar to 26S proteasome non-ATPase regulatory subunit 12 (...	343.0	[0..3]	[438..14]
PSD12_PONAB - 26S proteasome non-ATPase regulatory subunit 12 OS=Pongo abelii GN=PSMD12 PE=2 SV=3 PSD12_PONPY - 26S proteasome non-ATPase regulatory subunit 12 - Pongo pygmaeus (Orangutan)	341.0	[0..3]	[438..14]
gi\|123985956, gi... - gi\|168275714\|dbj\|BAG10577.1\| 26S proteasome non-ATPase regulatory subunit 12 [synthetic construct], ... gi\|114670121 - gi\|114670121\|ref\|XP_511639.2\| PREDICTED: proteasome 26S non-ATPase subunit 12 [Pan troglodytes] gi\|109117036 - gi\|109117036\|ref\|XP_001116817.1\| PREDICTED: proteasome 26S non-ATPase subunit 12 isoform 2 [Macaca m... PSMD12 - proteasome (prosome, macropain) 26S subunit, non-ATPase, 12	341.0	[0..3]	[438..14]
PSD12_BOVIN - 26S proteasome non-ATPase regulatory subunit 12 OS=Bos taurus GN=PSMD12 PE=2 SV=3	341.0	[0..3]	[438..14]
gi\|12857304 - gi\|12857304\|dbj\|BAB30969.1\| unnamed protein product [Mus musculus]	340.0	[0..3]	[438..14]
gi\|53136554, gi\|... - gi\|71897101\|ref\|NP_001025877.1\| proteasome 26S non-ATPase subunit 12 [Gallus gallus], gi\|53136554\|em...	340.0	[0..3]	[438..14]
gi\|54400716, gi\|... - gi\|54400716\|ref\|NP_001005875.1\| proteasome 26S non-ATPase subunit 12 [Rattus norvegicus], gi\|5373354...	340.0	[0..3]	[438..14]

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Predicted Domain #1

Region A:
Residues: [1-159]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEQKPEVDYS EKFAELQKSL NNLNTIDIDA NLEKLLIFEK QVRQASDTST NTKVLIYIAD  60
   61 LLFRAGDFQG LNEQLVSLFK KHGQLKQSMT SLVQHVMTYL PGIDDLKTKI NLIETLRTIT 120
  121 DGKIYVEVER ARLTQLLSQI KEEQGDIKSA QEILCNEPV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	7.045757
Match:	2fo7A
Description:	Crystal structure of an 8 repeat consensus TPR superhelix (trigonal crystal form)
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [160-265]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ETYGSFDLKE KVAFILDQVR LFLLRSDYYM ASTYTKKINV KFFEKEDVQS LKLKYYEQKI  60
   61 RIGLHDDAYL DVCKYYRAVY DTAVVQEDPE KWKEILENVV CFALLT

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	5.0
Match:	1na0A
Description:	Designed protein cTPR3
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [266-325]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PYDNEQADLL HRINADHKLN SLPLLQQLVK CFIVNELMRW PKIAEIYGSA LRSNPVFAEN  60
   61

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4

Region A:
Residues: [326-443]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DEKGEKRWSE LRKRVIEHNI RVVANYYSRI HCSRLGVLLD MSPSETEQFL CDLIAKHHFY  60
   61 AKIDRPAQVI SFKKSQNVQE QLNEWGSNIT ELLGKLEKVR QLIIKEEMMN SIQQAVAK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	12.09691
Match:	1ufmA
Description:	Solution structure of the PCI domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transcription regulator activity	3.50995556050336	bayes_pls_golite062009
nucleic acid binding	3.38144578566524	bayes_pls_golite062009
binding	3.33026160538031	bayes_pls_golite062009
DNA binding	3.30822066787723	bayes_pls_golite062009
transcription factor activity	2.60537570879007	bayes_pls_golite062009
hydrolase activity	2.30467124306022	bayes_pls_golite062009
structural constituent of ribosome	1.46680509390433	bayes_pls_golite062009
sequence-specific DNA binding	1.32971938164691	bayes_pls_golite062009
transcription activator activity	1.08566311616647	bayes_pls_golite062009
transcription repressor activity	0.95491822926452	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	0.845023110629115	bayes_pls_golite062009
protein binding	0.653872239015235	bayes_pls_golite062009
RNA polymerase II transcription factor activity	0.42135864069093	bayes_pls_golite062009
ubiquitin-protein ligase activity	0.136726704233672	bayes_pls_golite062009
small conjugating protein ligase activity	0.118016217031359	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: