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View Structure Prediction Details

Protein: rga2
Organism: Schizosaccharomyces pombe
Length: 1275 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for rga2.

Description E-value Query
Range
Subject
Range
gi|46096428, gi|... - gi|71005018|ref|XP_757175.1| hypothetical protein UM01028.1 [Ustilago maydis 521], ref|XP_398643.1| ...
474.0 [0..291] [1273..125]
orf19.10287, orf... - BEM3 CGDID:CAL0004269 Assembly 19, Contig19-10158 (236339, 232914) CDS, reverse complemented, transl...
gi|238881609 - gi|238881609|gb|EEQ45247.1| conserved hypothetical protein [Candida albicans WO-1]
gi|46442151, gi|... - gi|68471486|ref|XP_720291.1| hypothetical protein CaO19.10287 [Candida albicans SC5314], gi|68471028...
422.0 [0..39] [1248..4]
gi|53129828, gi|... - gi|71895381|ref|NP_001025775.1| SLIT-ROBO Rho GTPase activating protein 3 [Gallus gallus], gi|531298...
365.0 [0..861] [1270..324]
gi|76665090 - gi|76665090|ref|XP_878118.1| PREDICTED: similar to SLIT-ROBO Rho GTPase activating protein 3 isoform...
360.0 [0..861] [1270..324]
BEM3_YEAST - GTPase-activating protein BEM3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=BEM3 PE=1...
BEM3 - Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets...
360.0 [0..69] [1264..44]
gi|225000124 - gi|225000124|gb|AAI72359.1| SLIT-ROBO Rho GTPase activating protein 3 [synthetic construct]
SRGAP3 - SLIT-ROBO Rho GTPase activating protein 3
349.0 [0..861] [1270..324]
gi|109035846 - gi|109035846|ref|XP_001097218.1| PREDICTED: similar to SLIT-ROBO Rho GTPase activating protein 3 iso...
349.0 [0..861] [1270..324]
RHG15_MOUSE - Rho GTPase-activating protein 15 OS=Mus musculus GN=Arhgap15 PE=1 SV=1
348.0 [0..779] [1251..1]
gi|73985028 - gi|73985028|ref|XP_852764.1| PREDICTED: similar to SLIT-ROBO Rho GTPase activating protein 3 [Canis ...
348.0 [0..861] [1270..324]

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Predicted Domain #1
Region A:
Residues: [1-130]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVKMDVVRTT GFFLRSEPTT CRITTFAYSA EIIYFHAETT FLFEKIMKEG NELEKYSKIE  60
   61 LNSEIWEDEE EEDNSGIVSQ NERLMKLVNK QREIIYELHK DLEKVKKDNT SLRMRLSKYE 120
  121 STDSFPSSQP 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [131-347]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SRANSPQSDS YSSPYEKGKL FPKISLKSSK DVPTASAHIS SSDHEKSSSV SLSALNNYNK  60
   61 TTDIKARSLD RLSDMTRPKL LLNTKRSHRS SEEPGASSPV TSPILKDSQK ERIQALRNKA 120
  121 IKTYSVSTES AERIDSIRSD NLSPLSLNTS SFRRPITKPT PFNSDSNISI DPKDNNSNKQ 180
  181 DHFAEIEDEL RQQFLDIKVG RANASSPRRK SISIVKP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [348-450]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HGISSPKHST NNLSSKSGKF HSDFRVVSEN VLLQARSETN SPIIENKEAN NFLAPTSNVP  60
   61 AYSTPARPTE SPPPPPISSS STTPRPDDKP SLPPRGLSED NDS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [451-561]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LSLQKTGSSD TRRSSFSTLK IPDSDICFTR RRSDSNRTWT VIDPHHSQSF DNDILAEIPT  60
   61 SKLDNSSQKS PGKLSSKGLL NSFSPISPFS KSKSHNHHPS SQVEKSTSNS K

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [562-642]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GSMLPLDTLY NNKLSFRLDE SLVRYLRFEL MKTSLASLSP DFDCIGLQFV VGVSASSHLA  60
   61 SQWKDEVWSF TRSIGECRSF A

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [643-721]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TSFVLDIGAP PFPTLDWFTN DSSVIQNELL RRSVDTYFRY IFQTDLKLEQ RIKLLEFLSS  60
   61 DTLREYLHDV FFLPPEHAQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 6.30103
Match: 1xtnA
Description: crystal structure of CISK-PX domain with sulfates
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.39207685184342 bayes_pls_golite062009
protein binding 1.80677432725077 bayes_pls_golite062009

Predicted Domain #7
Region A:
Residues: [722-839]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KEGVLLKYIE NSGLVSRYFY LKDNILYFAE NRNSPVLGTI HLKDAQVNRY NANLPIFSII  60
   61 DPPHEFLTGE NYQSAFVIQE KQTETRTGTA TVHVLLARDV EDQKSWLRAI LRQVPGST

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 31.154902
Match: 1u2bA
Description: Triglycine variant of the Grp1 Pleckstrin Homology Domain unliganded
Matching Structure (courtesy of the PDB):

Predicted Domain #8
Region A:
Residues: [840-1275]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SPLNASPFSV LSSDFPGSSR YRDQSSPIRF YGKADSRPVS QEAILSQDIS SSPSPVLPPS  60
   61 ENVASYADDS LVSNLTMSPK LRDSMEQVPL ENHREFEISD RVSELSFDSS TGSVLEIADT 120
  121 RRNQDAPEKH VPVIEIQSSR PSLEKTDQST PVELLIDSHS QNSQNEEKRS RMKFWAFPHH 180
  181 KAENYEQISD TNIPVIETNV MLSPSSTTSA EPLQKHIVRK SGIFGLPLNE AVNISTQFND 240
  241 SGLPIVVYRC IEYLESCRAE KEEGIYRLSG SASTIKHLKE QFNEGVDYDL LSSDEEFDVH 300
  301 VIAGLLKLYL RNLPTNLLDT SMHKLFELLP NVPNDSAALG ELCDVISKLP PENFALLDSL 360
  361 LHHLRRIIAF EKVNKMNIRN VCIVFSPTLN IPSDIFMMLI LNYDHIFTDI SRQTNGAQNE 420
  421 SDSDVSDDNG EDNEFF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 80.522879
Match: 1xa6A
Description: Crystal Structure of the Human Beta2-Chimaerin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
Rho GTPase activator activity 4.45527136122296 bayes_pls_golite062009
Rac GTPase activator activity 4.36872878750284 bayes_pls_golite062009
GTPase regulator activity 2.61511682702035 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 2.59032629780818 bayes_pls_golite062009
binding 2.15139804299723 bayes_pls_golite062009
guanyl-nucleotide exchange factor activity 1.96768465804738 bayes_pls_golite062009
enzyme regulator activity 1.87657402052119 bayes_pls_golite062009
small GTPase regulator activity 1.85037053674911 bayes_pls_golite062009
protein binding 1.29100556128076 bayes_pls_golite062009
diacylglycerol binding 1.02792245495259 bayes_pls_golite062009
Ras GTPase activator activity 0.982302027631241 bayes_pls_golite062009
Rho guanyl-nucleotide exchange factor activity 0.890065668535699 bayes_pls_golite062009
Ras guanyl-nucleotide exchange factor activity 0.874385217290396 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.690843185161327 bayes_pls_golite062009
GTPase activator activity 0.635863123494771 bayes_pls_golite062009
kinase activity 0.411929190066223 bayes_pls_golite062009
enzyme activator activity 0.223298136783465 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.164035505126366 bayes_pls_golite062009
Rho GTPase binding 0.150587174126097 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle