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View Structure Prediction Details

Protein: rec8
Organism: Schizosaccharomyces pombe
Length: 561 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for rec8.

Description E-value Query
Range
Subject
Range
gi|73974375 - gi|73974375|ref|XP_861017.1| PREDICTED: similar to Double-strand-break repair protein rad21 homolog ...
441.0 [0..1] [557..1]
gi|208965416 - gi|208965416|dbj|BAG72722.1| RAD21 homolog [synthetic construct]
gi|114621389, gi... - gi|114621399|ref|XP_001138797.1| PREDICTED: RAD21 homolog isoform 8 [Pan troglodytes], gi|114621397|...
RAD21 - RAD21 homolog (S. pombe)
435.0 [0..1] [557..1]
gi|114621401 - gi|114621401|ref|XP_001138624.1| PREDICTED: RAD21 homolog isoform 6 [Pan troglodytes]
435.0 [0..1] [557..1]
gi|109087303, gi... - gi|109087311|ref|XP_001095142.1| PREDICTED: RAD21 homolog isoform 7 [Macaca mulatta], gi|109087309|r...
434.0 [0..1] [557..1]
RAD21_XENLA - Double-strand-break repair protein rad21 homolog OS=Xenopus laevis GN=rad21 PE=1 SV=1
433.0 [0..1] [557..1]
gi|157278125, gi... - gi|41349742|dbj|BAD08302.1| cohesin subunit Rad21 [Oryzias latipes], gi|157278125|ref|NP_001098161.1...
432.0 [0..1] [558..1]

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Predicted Domain #1
Region A:
Residues: [1-125]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFYNQDVLTK EKGGMGVIWL AATLGSKHSL RKLHKKDIMS VDIDEACDFV AFSPEPLALR  60
   61 LSSNLMIGVT RVWAHQYSFF HSQVSTLHLR VRKELDHFTS KPFKNIDIQN EQTNPKQLLL 120
  121 AEDPA

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 57.958607
Match: PF04825.4
Description: No description for PF04825.4 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [126-199]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FIPEVSLYDA FNLPSVDLHV DMSSFTQPKE NPNISVLETL PDSTSYLINT SQNYSLRNNV  60
   61 SSFVYEDSRA FSTE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [200-414]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EPLDFEFDEN GDIQELTKGT INSDPSLQAA SQHSNLGSVQ REYNSEEQES RIHMFEIDED  60
   61 VLPLPVPLQS VMDSEHNENE PRALKRRKVQ KLLEPDENIE LSTRTLSQWR KNYVERMIAL 120
  121 EATKYVRRRG ASSAKKKELN KFFDWESFHP LLKPWIEKLK PSNNTPSEID DVLRNIDTSE 180
  181 VEVGRDVQGE LGLNIPWNTS SRSNSAINSK SHSQT

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [415-561]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GSEHSTPLLD TKYRKRLPHS PSMPSRVEFL PALESSQFHE TLNSELSLQL SDDFVLYKNT  60
   61 QEENAHLMLS MEKECANFYE YAKTAIYENN GRITFSSLLP NDLKRPVVAQ AFSHLLSLAT 120
  121 KSAFLVKQDK PYSEISVSLN LKSTDAI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11.69897
Match: 1w1wE
Description: Sc Smc1hd:Scc1-C complex, ATPgS
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 3.74762577068811 bayes_pls_golite062009
DNA binding 3.6691593040775 bayes_pls_golite062009
nucleic acid binding 3.56696430931691 bayes_pls_golite062009
binding 3.33026160538031 bayes_pls_golite062009
transcription factor activity 2.86565145658031 bayes_pls_golite062009
sequence-specific DNA binding 1.56454590328755 bayes_pls_golite062009
transcription activator activity 1.36544833032097 bayes_pls_golite062009
transcription repressor activity 1.22911517186886 bayes_pls_golite062009
structure-specific DNA binding 0.913018999939773 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.71350728967175 bayes_pls_golite062009
DNA-dependent ATPase activity 0.697234220778482 bayes_pls_golite062009
protein binding 0.653872239015235 bayes_pls_golite062009
DNA helicase activity 0.300899564141452 bayes_pls_golite062009
hydrolase activity 0.140191206949582 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle