YRC Public Data Repository - Protein Structure Prediction

Protein:	SPBC577.10
Organism:	Schizosaccharomyces pombe
Length:	262 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPBC577.10.

Description	E-value	Query Range	Subject Range
PSA_PYRAB - Proteasome subunit alpha OS=Pyrococcus abyssi (strain GE5 / Orsay) GN=psmA PE=3 SV=1 PSMA_PYRAB - Proteasome subunit alpha OS=Pyrococcus abyssi GN=psmA PE=3 SV=1	240.0	[0..13]	[248..6]
PSA_PYRHO - Proteasome subunit alpha OS=Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC ... PSMA_PYRHO - Proteasome subunit alpha OS=Pyrococcus horikoshii GN=psmA PE=3 SV=1	238.0	[0..13]	[248..6]
PSA_PYRFU - Proteasome subunit alpha OS=Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) GN=p... PSMA_PYRFU - Proteasome subunit alpha OS=Pyrococcus furiosus GN=psmA PE=3 SV=1	238.0	[0..13]	[248..6]
PSMA_METKA - Proteasome subunit alpha OS=Methanopyrus kandleri GN=psmA PE=3 SV=1 PSA_METKA - Proteasome subunit alpha OS=Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938) ...	237.0	[0..17]	[249..10]
gi\|50304213, gi\|... - gi\|50304213\|ref\|XP_452056.1\| unnamed protein product [Kluyveromyces lactis], gi\|49641188\|emb\|CAH0244... gi\|49641188 - gi\|49641188\|emb\|CAH02449.1\| KLLA0B11836p [Kluyveromyces lactis]	234.0	[0..14]	[256..1]
PSA_THEK1 - Proteasome subunit alpha OS=Thermococcus sp. (strain JCM 11816 / KS-1) GN=psmA PE=3 SV=1 PSA_THEK1, PSMA_... - Proteasome subunit alpha OS=Thermococcus sp. (strain KS-1) GN=psmA PE=3 SV=1, Proteasome subunit alp... gi\|11265988 - pir\|\|T43887 proteasome alpha chain [imported] - Thermococcus sp	233.0	[0..13]	[251..6]
PSMA_PYRKO - Proteasome subunit alpha OS=Pyrococcus kodakaraensis GN=psmA PE=3 SV=1 PSA_THEKO - Proteasome subunit alpha OS=Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) GN=ps...	232.0	[0..13]	[251..6]
gi\|218186097 - gi\|218186097\|gb\|EEC68524.1\| hypothetical protein OsI_36813 [Oryza sativa Indica Group] PSA5_ORYSJ - Proteasome subunit alpha type-5 OS=Oryza sativa subsp. japonica GN=PAE1 PE=2 SV=1 PSA5_ORYSA - Proteasome subunit alpha type 5 (EC 3.4.25.1) (20S proteasome alpha subunit E) (20S proteasome subun...	230.0	[0..10]	[249..1]
gi\|65304454 - gi\|65304454\|emb\|CAI76833.1\| proteasome subunit, putative [Theileria annulata] gi\|84997473 - gi\|84997473\|ref\|XP_953458.1\| proteasome subunit [Theileria annulata strain Ankara]	228.0	[0..15]	[261..3]
gi\|47230708 - gi\|47230708\|emb\|CAF99901.1\| unnamed protein product [Tetraodon nigroviridis]	228.0	[0..15]	[249..2]

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Predicted Domain #1

Region A:
Residues: [1-262]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSFLELTEVW GKPQKDIFFP SGSEVEESTD APIQRTVQPI VTGSSVLALK FADGVMIAAD  60
   61 NLASYGSLAR FYDVERLTKV GDNTIVGAGG DISDYQQIQR LLEKLEIKEG NYGDGYALQP 120
  121 SYIHEYLSKV LYARRNKLDP YWNQLIVAGV DGENKEPYVA FADLRGTTYS APAIATGFAM 180
  181 HLALPMLRKA TDDDRWKTLS KESARATIDE CMRVLFYRDA RSLNKFSVAT ITPEGIEFQT 240
  241 DQSVSSKWAF AEKQYGYGTQ TV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	38.30103
Match:	1g0uM
Description:	Proteasome beta subunit (catalytic)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
endopeptidase activity	6.91642761177919	bayes_pls_golite062009
peptidase activity	6.84511694091156	bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides	6.5973571808298	bayes_pls_golite062009
hydrolase activity	4.47652590304822	bayes_pls_golite062009
threonine-type endopeptidase activity	2.98214579292788	bayes_pls_golite062009
threonine-type peptidase activity	2.98214579292788	bayes_pls_golite062009
binding	1.75265921676176	bayes_pls_golite062009
nucleic acid binding	1.39216781236247	bayes_pls_golite062009
catalytic activity	1.19663085909195	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: