YRC Public Data Repository - Protein Structure Prediction

Protein:	pzh1
Organism:	Schizosaccharomyces pombe
Length:	515 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for pzh1.

Description	E-value	Query Range	Subject Range
gi\|46107938, gi\|... - gi\|46107938\|ref\|XP_381028.1\| hypothetical protein FG00852.1 [Gibberella zeae PH-1], gi\|42547602\|gb\|E...	399.0	[0..7]	[515..19]
gi\|85116346 - gi\|85116346\|ref\|XP_965036.1\| serine/threonine-protein phosphatase PP-Z [Neurospora crassa OR74A] gi\|28926837, gi\|... - gi\|32414591\|ref\|XP_327775.1\| hypothetical protein ( (AF071751) protein phosphatase-Z-like serine/thr...	392.0	[0..2]	[515..10]
gi\|4193369, gi\|4... - gi\|4193369\|gb\|AAD09996.1\| protein phosphatase-Z-like serine/threonine protein phosphatase [Neurospor...	386.0	[0..2]	[515..10]
gi\|91081641 - gi\|91081641\|ref\|XP_966417.1\| PREDICTED: similar to protein phosphatase 1, catalytic subunit, beta is...	375.0	[0..206]	[511..21]
gi\|71017993, gi\|... - gi\|71017993\|ref\|XP_759227.1\| serine/threonine protein phosphatase [Ustilago maydis 521], ref\|XP_4006...	374.0	[0..193]	[514..12]
gi\|134108372, gi... - gi\|50259822\|gb\|EAL22490.1\| hypothetical protein CNBB3690 [Cryptococcus neoformans var. neoformans B-... gi\|57223783, gi\|... - gi\|58263446\|ref\|XP_569133.1\| protein phosphatase type 1 [Cryptococcus neoformans var. neoformans JEC...	373.0	[0..217]	[510..33]
gi\|7435129, gi\|3... - pir\|\|T09544 phosphoprotein phosphatase (EC 3.1.3.16), catalytic beta chain - alfalfa, gi\|3176072\|emb...	373.0	[0..206]	[511..18]
gi\|22001279 - gi\|22001279\|gb\|AAM88380.1\|AF525131_1 protein phosphatase type 1 catalytic subunit delta isoform [Can...	373.0	[0..213]	[511..28]
gi\|68490042, gi\|... - gi\|68490079\|ref\|XP_711124.1\| potential protein phosphatase [Candida albicans SC5314], gi\|68490042\|re... orf19.13664, orf... - GLC7 CGDID:CAL0000595 Assembly 19, Contig19-10242 (5105, 4113) CDS, reverse complemented, translated... gi\|238880172 - gi\|238880172\|gb\|EEQ43810.1\| serine/threonine-protein phosphatase PP1 [Candida albicans WO-1]	373.0	[0..181]	[508..1]
gi\|227436 - gi\|227436\|prf\|\|1703469D protein phosphatase 1 delta	372.0	[0..213]	[511..28]

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Predicted Domain #1

Region A:
Residues: [1-188]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGQGSSKHAD SKLDSYPSFS RSDTQGSIKS LKSLKTVLGK GKDSNHDRRT STDTTHSRHR  60
   61 YPETPPSLPP PPSPGILATS PAVLQKHQQE DSGNSSQSPT SPHPSNQPAM LSPSTAASQH 120
  121 HHHHSSSSSY AVSPTSPTSP TSSGPIGSNF DSASEHNGPV YPQDQQGPVI IPNSAISSTD 180
  181 PDDPETVV

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	1.24
Match:	2j63A
Description:	No description for 2j63A was found.

Predicted Domain #2

Region A:
Residues: [189-515]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SLNVDEMIQR LIHVGYSRKS SKSVCLKNAE ITSICMAVRE IFLSQPTLLE LTPPVKIVGD  60
   61 VHGQYSDLIR LFEMCGFPPS SNYLFLGDYV DRGKQSLETI LLLFLYKIRY PENFFLLRGN 120
  121 HECANITRVY GFYDECKRRC NIKIWKTFIN TFNCLPIASV VAGKIFCVHG GLSPSLSHMD 180
  181 DIREIPRPTD VPDYGLLNDL LWSDPADTEN DWEDNERGVS FVFNKNVIRQ FLAKHDFDLI 240
  241 CRAHMVVEDG YEFFNDRTLC TVFSAPNYCG EFDNWGAVMS VNSELLCSFE LIKPLDQAAI 300
  301 RRELKKSKRS GMAIYQSPPA EQVTQSV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	103.0
Match:	1s70A
Description:	Complex between protein ser/thr phosphatase-1 (delta) and the myosin phosphatase targeting subunit 1 (MYPT1)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
phosphoprotein phosphatase activity	11.6417995308386	bayes_pls_golite062009
protein serine/threonine phosphatase activity	10.6440947462013	bayes_pls_golite062009
phosphatase activity	10.5525832502704	bayes_pls_golite062009
phosphoric ester hydrolase activity	10.3702645338723	bayes_pls_golite062009
hydrolase activity, acting on ester bonds	9.02791306892273	bayes_pls_golite062009
calcium-dependent protein serine/threonine phosphatase activity	6.04386346716682	bayes_pls_golite062009
myosin phosphatase activity	5.31703100176823	bayes_pls_golite062009
hydrolase activity	3.13006743434485	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	1.68552051869632	bayes_pls_golite062009
kinase activity	1.67788383575784	bayes_pls_golite062009
structural molecule activity	1.5850868178597	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	1.57807175808088	bayes_pls_golite062009
protein kinase activity	1.4514460578232	bayes_pls_golite062009
binding	1.44538582463569	bayes_pls_golite062009
catalytic activity	1.39852585255405	bayes_pls_golite062009
transferase activity	1.3407391509244	bayes_pls_golite062009
protein binding	1.33435965029646	bayes_pls_golite062009
transporter activity	1.24767072239634	bayes_pls_golite062009
molecular transducer activity	1.08090214431427	bayes_pls_golite062009
signal transducer activity	1.08090214431427	bayes_pls_golite062009
calmodulin binding	0.77173071932406	bayes_pls_golite062009
protein serine/threonine kinase activity	0.66803085638835	bayes_pls_golite062009
substrate-specific transporter activity	0.528189469950839	bayes_pls_golite062009
structural constituent of muscle	0.126411744957937	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: