YRC Public Data Repository - Protein Structure Prediction

Protein:	SPBC776.15c
Organism:	Schizosaccharomyces pombe
Length:	452 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPBC776.15c.

Description	E-value	Query Range	Subject Range
gi\|23467322, gi\|... - gi\|23467322\|ref\|ZP_00122905.1\| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam...	423.0	[0..40]	[451..1]
gi\|126096730, gi... - gi\|126207938\|ref\|YP_001053163.1\| dihydrolipoyllysine-residue succinyltransferase component of 2-oxog... gi\|32034768 - gi\|32034768\|ref\|ZP_00134893.1\| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam... gi\|189914931, gi... - gi\|190149800\|ref\|YP_001968325.1\| dihydrolipoyllysine-residue succinyltransferase component of 2-oxog...	423.0	[0..42]	[451..2]
gi\|15602143, gi\|... - gi\|15602143\|ref\|NP_245215.1\| hypothetical protein PM0278 [Pasteurella multocida subsp. multocida str...	423.0	[0..40]	[451..1]
gi\|32030043, gi\|... - gi\|32030043\|ref\|ZP_00132963.1\| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam...	423.0	[0..40]	[451..1]
gi\|53732513 - gi\|53732513\|ref\|ZP_00154561.2\| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam... gi\|48868188, gi\|... - gi\|68250263\|ref\|YP_249375.1\| dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydr...	418.0	[0..42]	[451..2]
gi\|90438940, gi\|... - gi\|90580055\|ref\|ZP_01235863.1\| dihydrolipoamide acetyltransferase [Vibrio angustum S14], gi\|90438940...	418.0	[0..42]	[451..2]
gi\|89073521, gi\|... - gi\|89073521\|ref\|ZP_01160044.1\| dihydrolipoamide acetyltransferase [Photobacterium sp. SKA34], gi\|890...	417.0	[0..42]	[451..2]
gi\|84690477, gi\|... - gi\|84704043\|ref\|ZP_01017871.1\| dihydrolipoamide acetyltransferase [Parvularcula bermudensis HTCC2503...	416.0	[0..38]	[451..106]
gi\|144982919 - gi\|144982919\|gb\|EDJ90432.1\| carboxy-terminal protease [Haemophilus influenzae R3021] gi\|145639183, gi... - gi\|145639183\|ref\|ZP_01794790.1\| carboxy-terminal protease [Haemophilus influenzae PittII], gi\|145271... gi\|145631489 - gi\|145631489\|ref\|ZP_01787258.1\| carboxy-terminal protease [Haemophilus influenzae 22.4-21] gi\|46133588 - gi\|46133588\|ref\|ZP_00157429.2\| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam...	416.0	[0..42]	[451..2]
ODO2_HAEIN - Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex OS... ODO2_HAEIN - Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex OS...	415.0	[0..42]	[451..2]

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Predicted Domain #1

Region A:
Residues: [1-214]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTSYGNGFRM MAKCLLSLRS GYSVTAPVSK SMANVLWARY ASTRIKTPPF PESITEGTLA  60
   61 QWLKQPGEYV NKDEEIASVE TDKIDAPVTA PDAGVLKEQL VKEGDTITID QDIAVIDTSA 120
  121 APPEGGSAGP KKDEVKTADA DAAKDLSTPQ DSSKPIEEKP MPDLGAEQKE SAPSSTKPAP 180
  181 DAKEPEFSSP KPKPAKSEPV KQSKPKATET ARPS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	22.39794
Match:	1zy8K
Description:	The crystal structure of dihydrolipoamide dehydrogenase and dihydrolipoamide dehydrogenase-binding protein (didomain) subcomplex of human pyruvate dehydrogenase complex.
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [215-452]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SFSRNEDRVK MNRMRLRIAE RLKESQNRAA SLTTFNECDM SAVVALRKKY KDEILKETGV  60
   61 KIGFMSFFSK ACTQAMKQIP AINGSIEGEG KGDTLVYRDF CDLSIAVATP KGLVTPVIRN 120
  121 AESMSLLEIE SAIATLGSKA RAGKLAIEDM ASGTFTISNG GIFGSLYGTP IINLPQTAVL 180
  181 GLHAIKERPV VINGQVVPRP MMYLALTYDH RMVDGREAVT FLRLVKEYIE DPAKMLLV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	87.30103
Match:	1c4tA
Description:	Dihydrolipoamide succinyltransferase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
S-succinyltransferase activity	10.0778678835755	bayes_pls_golite062009
dihydrolipoyllysine-residue succinyltransferase activity	10.0778678835755	bayes_pls_golite062009
dihydrolipoyllysine-residue acetyltransferase activity	9.65061123545754	bayes_pls_golite062009
dihydrolipoamide S-acyltransferase activity	9.64995677986911	bayes_pls_golite062009
S-acetyltransferase activity	9.49696044977584	bayes_pls_golite062009
S-acyltransferase activity	8.45313874919036	bayes_pls_golite062009
pyruvate dehydrogenase activity	8.17557182322815	bayes_pls_golite062009
transferase activity, transferring acyl groups other than amino-acyl groups	6.86215901871647	bayes_pls_golite062009
acyltransferase activity	6.83977352892719	bayes_pls_golite062009
succinyltransferase activity	6.58826720904067	bayes_pls_golite062009
pyruvate dehydrogenase (acetyl-transferring) activity	6.40483178382327	bayes_pls_golite062009
acetyltransferase activity	6.08159176722072	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	5.93985773477717	bayes_pls_golite062009
transferase activity, transferring acyl groups	4.60481199262496	bayes_pls_golite062009
carnitine O-acyltransferase activity	2.87366177129153	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors	2.54513901872655	bayes_pls_golite062009
catalytic activity	1.51562638409295	bayes_pls_golite062009
O-acyltransferase activity	1.33852311685118	bayes_pls_golite062009
O-palmitoyltransferase activity	1.22729402619659	bayes_pls_golite062009
carnitine O-palmitoyltransferase activity	1.22729402619659	bayes_pls_golite062009
transferase activity	1.08341671157927	bayes_pls_golite062009
carnitine O-acetyltransferase activity	1.00868366840715	bayes_pls_golite062009
binding	0.801074244553007	bayes_pls_golite062009
alpha-ketoacid dehydrogenase activity	0.79135670574828	bayes_pls_golite062009
O-acetyltransferase activity	0.54660034926676	bayes_pls_golite062009
protein binding	0.00454070917775817	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: