YRC Public Data Repository - Protein Structure Prediction

Protein:	met26
Organism:	Schizosaccharomyces pombe
Length:	764 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for met26.

Description	E-value	Query Range	Subject Range
gi\|89104874 - gi\|89104874\|ref\|ZP_01177405.1\| COG0620: Methionine synthase II (cobalamin-independent) [Yersinia pes... gi\|167426239, gi... - gi\|167426239\|ref\|ZP_02317992.1\| 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransfer... gi\|22124357, gi\|... - gi\|22124357\|ref\|NP_667780.1\| 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase [... gi\|77633875, gi\|... - gi\|77633875\|ref\|ZP_00795989.1\| COG0620: Methionine synthase II (cobalamin-independent) [Yersinia pes... gi\|167401849, gi... - gi\|167401849\|ref\|ZP_02307337.1\| 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransfer... gi\|166213623, gi... - gi\|166213623\|ref\|ZP_02239658.1\| 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransfer...	992.0	[0..2]	[762..8]
gi\|149289461, gi... - gi\|153997155\|ref\|ZP_02022288.1\| 5-methyltetrahydropteroyltriglutamate-- homocystei ne methyltransfer... gi\|165921840, gi... - gi\|165926316\|ref\|ZP_02222148.1\| 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransfer... gi\|165939105, gi... - gi\|165939105\|ref\|ZP_02227656.1\| 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransfer... gi\|165989400, gi... - gi\|166011631\|ref\|ZP_02232529.1\| 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransfer... gi\|166961025, gi... - gi\|167420896\|ref\|ZP_02312649.1\| 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransfer... gi\|229695839, gi... - gi\|229839473\|ref\|ZP_04459632.1\| 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransfera... gi\|229686816, gi... - gi\|229900036\|ref\|ZP_04515173.1\| 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransfera... gi\|229706057, gi... - gi\|229837114\|ref\|ZP_04457279.1\| 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransfera... METE_YERPE - 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase OS=Yersinia pestis GN=metE PE=... METE_YERPN - 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase OS=Yersinia pestis bv. Antiqua... METE_YERPA - 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase OS=Yersinia pestis bv. Antiqua... gi\|45437880, gi\|... - gi\|45443013\|ref\|NP_994552.1\| 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase [... gi\|218930790, gi... - gi\|218930790\|ref\|YP_002348665.1\| 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransfe...	991.0	[0..2]	[762..3]
gi\|77384769, gi\|... - gi\|77460766\|ref\|YP_350273.1\| 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase [...	990.0	[0..1]	[764..20]
gi\|77630686, gi\|... - gi\|77630686\|ref\|ZP_00793272.1\| COG0620: Methionine synthase II (cobalamin-independent) [Yersinia pse...	989.0	[0..2]	[762..8]
METE_PHOLL - 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase OS=Photorhabdus luminescens su... METE_PHOLL - 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase OS=Photorhabdus luminescens su...	989.0	[0..1]	[761..1]
gi\|77973685 - gi\|77973685\|ref\|ZP_00829231.1\| COG0620: Methionine synthase II (cobalamin-independent) [Yersinia fre...	988.0	[0..2]	[762..3]
METE_YERPS - 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase OS=Yersinia pseudotuberculosis... METE_YERPS - 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase OS=Yersinia pseudotuberculosis...	988.0	[0..2]	[762..3]
METE_ECOK1 - 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase OS=Escherichia coli O1:K1 / AP...	985.0	[0..2]	[760..3]
METE_ECO45 - 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase OS=Escherichia coli O45:K1 (st... gi\|237702839, gi... - gi\|237702839\|ref\|ZP_04533320.1\| 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferase... METE_ECOUT - 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase OS=Escherichia coli (strain UT...	984.0	[0..2]	[760..3]
gi\|75256247, gi\|... - gi\|75256247\|ref\|ZP_00727925.1\| COG0620: Methionine synthase II (cobalamin-independent) [Escherichia ... gi\|193067979, gi... - gi\|75238279\|ref\|ZP_00722278.1\| COG0620: Methionine synthase II (cobalamin-independent) [Escherichia ... gi\|75209544, gi\|... - gi\|75209544\|ref\|ZP_00709765.1\| COG0620: Methionine synthase II (cobalamin-independent) [Escherichia ...	984.0	[0..2]	[760..3]

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Predicted Domain #1

Region A:
Residues: [1-764]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVKSAVLGFP RIGKNRELKK ATEAYWSGKT SAEELLATAK QLRLEHWKLQ KAQGVDIIPS  60
   61 NDFSLYDQIM DHSFSFNVIP PRYRLSGLSS LDTYFAMGRG MQRAATADKA AVDVPAGEMV 120
  121 KWFDSNYHFL RPEVSEETDF KLSSTKALDE FLEAKEAGII TRPVLVGPVT YLFIAKAAKG 180
  181 SSIKPIELLP KLLPVYVELI KKLTEAGAEY IQIDEPILTL DLPQEILASY KEAYETLGKI 240
  241 GKLILTTYFG SLQSNADVLK GLPIAGVHVD VVRAPENLDR ALAVLGENQI ISVGVVSGRN 300
  301 IWKTDFQKAT AIIEKAISAV GSERVQVASS SSILHIPHSL SGEDQINPEI KRWFAFAVEK 360
  361 CAELAILTKA ANDGPASVRA ELEANAADCK ARAESPITNV EAVRERQSKV TPQMHERKSP 420
  421 FETRYAKQQA SLKLPLFPTT TIGSFPQTKE IRVTRNRFAK GLISQEEYDA FIRKEISDVV 480
  481 KFQEEVGLDV LVHGEPERND MVQYFGERME GFVFTVNGWV QSYGSRCVRP PIIVGDVYRP 540
  541 APMTVKESQY AQSITSKPMK GMLTAPITIL RWSFPRDDVH DSVQAQQIAL GLRDEVLDLE 600
  601 KAGIKVIQCD EPALREGLPL RRAEWDEYLK WAIDAFRLAT AAVQDDTQIH SHFCYSDFND 660
  661 IFDAIQRLDA DVVSIENSKS DMKLLNVLSR YTSCIGPGLF DIHSPRVPPV SEFKERIDAI 720
  721 VKHVPKDHLW LNPDCGLKTR GWPETTADLK NMIAAAREAR EQYA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1000.0
Match:	1u1hA
Description:	A. thaliana cobalamine independent methionine synthase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity	6.40786073037099	bayes_pls_golite062009
5-methyltetrahydropteroyltri-L-glutamate-dependent methyltransferase activity	6.40786073037099	bayes_pls_golite062009
uroporphyrinogen decarboxylase activity	3.13638443707338	bayes_pls_golite062009
S-methyltransferase activity	3.0142199413027	bayes_pls_golite062009
catalytic activity	2.37862248560593	bayes_pls_golite062009
binding	1.590130518929	bayes_pls_golite062009
carbon-carbon lyase activity	1.54242506764415	bayes_pls_golite062009
carboxy-lyase activity	1.52150758949987	bayes_pls_golite062009
lyase activity	0.825209465219608	bayes_pls_golite062009
protein binding	0.21865699924356	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: