YRC Public Data Repository - Protein Structure Prediction

Protein:	tmp1
Organism:	Schizosaccharomyces pombe
Length:	210 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for tmp1.

Description	E-value	Query Range	Subject Range
gi\|40215537 - gi\|40215537\|gb\|AAL48064.2\| RE69454p [Drosophila melanogaster]	159.0	[0..1]	[210..15]
gi\|56494802 - gi\|56494802\|emb\|CAH95718.1\| thymidylate kinase, putative [Plasmodium berghei] gi\|68067163 - gi\|68067163\|ref\|XP_675552.1\| thymidylate kinase [Plasmodium berghei strain ANKA]	157.0	[0..2]	[210..10]
gi\|54635901, gi\|... - gi\|54635901\|gb\|EAL25304.1\| GA19108 [Drosophila pseudoobscura pseudoobscura], gi\|125808374\|ref\|XP_001... gi\|54635901\|gb\|E... - GA19108-PA [Drosophila pseudoobscura], GA19108 [Drosophila pseudoobscura pseudoobscura]	156.0	[0..1]	[201..1]
gi\|86608314 - gi\|86608314\|ref\|YP_477076.1\| thymidylate kinase [Cyanobacteria bacterium Yellowstone B-Prime] KTHY_SYNJB - Thymidylate kinase OS=Synechococcus sp. (strain JA-2-3B'a(2-13)) GN=tmk PE=3 SV=1	150.0	[0..8]	[202..1]
gi\|118351574 - gi\|118351574\|ref\|XP_001009062.1\| thymidylate kinase family protein [Tetrahymena thermophila] gi\|118351574, gi... - gi\|89290829\|gb\|EAR88817.1\| thymidylate kinase family protein [Tetrahymena thermophila SB210], gi\|118...	150.0	[0..1]	[201..1]
gi\|71018245, gi\|... - gi\|71018245\|ref\|XP_759353.1\| hypothetical protein UM03206.1 [Ustilago maydis 521], ref\|XP_400821.1\| ...	150.0	[0..3]	[201..422]
gi\|23497027, gi\|... - gi\|23509185\|ref\|NP_701853.1\| thymidylate kinase, putative [Plasmodium falciparum 3D7], gi\|23497027\|g...	149.0	[0..1]	[202..1]
KTHY_PYRFU - Probable thymidylate kinase OS=Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) G... KTHY_PYRFU - Probable thymidylate kinase OS=Pyrococcus furiosus GN=tmk PE=3 SV=1	146.0	[0..4]	[201..1]
gi\|62424658 - gi\|62424658\|ref\|ZP_00379801.1\| COG0477: Permeases of the major facilitator superfamily [Brevibacteri...	146.0	[0..7]	[205..426]

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Predicted Domain #1

Region A:
Residues: [1-210]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKQNRGRLI VIEGLDRSGK STQCQLLVDK LISQHEKAEL FKFPDRTTAI GKKIDDYLKE  60
   61 SVQLNDQVIH LLFSANRWET IQYIYEQINK GVTCILDRYA FSGIAFSAAK GLDWEWCKSP 120
  121 DRGLPRPDLV IFLNVDPRIA ATRGQYGEER YEKIEMQEKV LKNFQRLQKE FREEGLEFIT 180
  181 LDASSSLEDV HSQIVDLVSN VNIHETLDVL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	33.39794
Match:	1e9fA
Description:	Thymidylate kinase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
nucleobase, nucleoside, nucleotide kinase activity	3.66392587433723	bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism	3.01286198424677	bayes_pls_golite062009
nucleotide kinase activity	2.24094813695083	bayes_pls_golite062009
kinase activity	2.0779386406753	bayes_pls_golite062009
hydrogen ion transmembrane transporter activity	2.06460241490722	bayes_pls_golite062009
binding	2.05253348982328	bayes_pls_golite062009
substrate-specific transporter activity	2.0114051513686	bayes_pls_golite062009
phosphotransferase activity, phosphate group as acceptor	1.96697952975573	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	1.92626167278464	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	1.9136419736217	bayes_pls_golite062009
ion transmembrane transporter activity	1.6854386921174	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	1.64467072658718	bayes_pls_golite062009
cation transmembrane transporter activity	1.5008821138859	bayes_pls_golite062009
nucleic acid binding	1.49633029954726	bayes_pls_golite062009
pyrophosphatase activity	1.49611313354225	bayes_pls_golite062009
DNA-dependent ATPase activity	1.2155186842031	bayes_pls_golite062009
helicase activity	1.16085745407703	bayes_pls_golite062009
catalytic activity	1.00104173493322	bayes_pls_golite062009
DNA binding	0.967303417236485	bayes_pls_golite062009
transcription regulator activity	0.748437190903548	bayes_pls_golite062009
DNA helicase activity	0.72881469450553	bayes_pls_golite062009
structure-specific DNA binding	0.720649395550746	bayes_pls_golite062009
ATP-dependent helicase activity	0.59513742813869	bayes_pls_golite062009
purine NTP-dependent helicase activity	0.59513742813869	bayes_pls_golite062009
double-stranded DNA binding	0.58862275163252	bayes_pls_golite062009
adenylate kinase activity	0.447752711852745	bayes_pls_golite062009
CTP synthase activity	0.435702031552231	bayes_pls_golite062009
protein-DNA loading ATPase activity	0.3625050107782	bayes_pls_golite062009
DNA clamp loader activity	0.27925703205288	bayes_pls_golite062009
ATP-dependent DNA helicase activity	0.22150712609541	bayes_pls_golite062009
protein binding	0.193768631623192	bayes_pls_golite062009
nucleotide binding	0.114848452385726	bayes_pls_golite062009
purine nucleotide binding	0.10713474095071	bayes_pls_golite062009
purine ribonucleotide binding	0.0916519414118148	bayes_pls_golite062009
ribonucleotide binding	0.0915913646217636	bayes_pls_golite062009
DNA polymerase activity	4.95561462330096E-4	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: