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View Structure Prediction Details

Protein: krp1
Organism: Schizosaccharomyces pombe
Length: 709 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for krp1.

Description E-value Query
Range
Subject
Range
PCSK6 - proprotein convertase subtilisin/kexin type 6
463.0 [0..17] [641..62]
gi|94380599 - gi|94380599|ref|XP_980634.1| PREDICTED: similar to Proprotein convertase subtilisin/kexin type 6 pre...
463.0 [0..23] [641..60]

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Predicted Domain #1
Region A:
Residues: [1-123]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHPALLCGPI LAIFLQFLVS SCSPLENDDL FLVQVEPEVD PVVAAEAIGA KYVRPLLNLK  60
   61 YHHLIKLHKG SDDSVQSSIR KRGIDAGILE LERQTPRWRY KRDASESDEL LNEFSNHFGI 120
  121 SDP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 45.522879
Match: 1r6vA
Description: Crystal structure of fervidolysin from Fervidobacterium pennivorans, a keratinolytic enzyme related to subtilisin
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [124-597]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LFYGQWHIFN SNNPGHDLNL REVWDAGYFG ENVTVAFVDD GIDFKHPDLQ AAYTSLGSWD  60
   61 FNDNIADPLP KLSDDQHGTR CAGEVAAAWN DVCGVGIAPR AKVAGLRILS APITDAVESE 120
  121 ALNYGFQTNH IYSCSWGPAD DGRAMDAPNT ATRRALMNGV LNGRNGLGSI FVFASGNGGH 180
  181 YHDNCNFDGY TNSIFSATIG AVDAEHKIPF YSEVCAAQLV SAYSSGSHLS ILTTNPEGTC 240
  241 TRSHGGTSAA APLASAVYAL ALSIRPDLSW RDIQHITVYS ASPFDSPSQN AEWQKTPAGF 300
  301 QFSHHFGFGK LDASKFVEVA KDWQVVNPQT WLIAPEINVN KSFGSVNNET ITEMVSEFTV 360
  361 TKDMIEKSNF KRLEHVTVRV CIPFNRRGAL EILLESPSGI RSILASERPY DENSKGFLDW 420
  421 TFMTVQHWAE PPEGVWKLLV NDRSGGKHEG TFENWQLALW GESENPSNTA PLPY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 97.221849
Match: 2id4A
Description: No description for 2id4A was found.

Predicted functions:

Term Confidence Notes
peptidase activity 4.77677490610016 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 4.40501322467328 bayes_pls_golite062009
serine hydrolase activity 4.30899317351154 bayes_pls_golite062009
serine-type peptidase activity 4.29545891350519 bayes_pls_golite062009
nerve growth factor binding 3.93556598541015 bayes_pls_golite062009
endopeptidase activity 3.83336601331518 bayes_pls_golite062009
serine-type endopeptidase activity 3.71508033196614 bayes_pls_golite062009
neurotrophin binding 3.66310728475581 bayes_pls_golite062009
hydrolase activity 2.05732080397524 bayes_pls_golite062009
eukaryotic cell surface binding 1.50287724152407 bayes_pls_golite062009
binding 1.08901362883653 bayes_pls_golite062009
growth factor binding 0.67723819767183 bayes_pls_golite062009
catalytic activity 0.597535457699629 bayes_pls_golite062009
exopeptidase activity 0.42083764849682 bayes_pls_golite062009
protein binding 0.380935140681308 bayes_pls_golite062009
receptor binding 0.222369968782666 bayes_pls_golite062009
glycosaminoglycan binding 0.11649614154172 bayes_pls_golite062009
cell surface binding 0.0917795720340502 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [598-709]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DTLELPKEMV LGIYSEPNSD LTNSSTLLSP TSTSFTSYTV SATATPTSTS HIPIPTVLPP  60
   61 TQPVLEPSYR EIVAFITFFL LFAFIFVAVI WTWISAFWKA KAPPPLSQQE IA

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle