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View Structure Prediction Details

Protein: spb70
Organism: Schizosaccharomyces pombe
Length: 574 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for spb70.

Description E-value Query
Range
Subject
Range
gi|145018360, gi... - gi|39974295|ref|XP_368538.1| hypothetical protein MGG_00706 [Magnaporthe grisea 70-15], gb|EAA49048....
534.0 [0..7] [574..21]
DPOA2_MOUSE - DNA polymerase alpha subunit B OS=Mus musculus GN=Pola2 PE=1 SV=2
532.0 [0..7] [574..20]
gi|46125287, gi|... - gi|46125287|ref|XP_387197.1| hypothetical protein FG07021.1 [Gibberella zeae PH-1], gi|42553708|gb|E...
526.0 [0..7] [574..17]
gi|32404572, gi|... - gi|32404572|ref|XP_322899.1| hypothetical protein [Neurospora crassa], gi|28922868|gb|EAA32088.1| hy...
gi|85102431 - gi|85102431|ref|XP_961324.1| hypothetical protein [Neurospora crassa OR74A]
526.0 [0..8] [574..22]
gi|114638538, gi... - gi|114638540|ref|XP_001169495.1| PREDICTED: polymerase (DNA directed), alpha 2 (70kD subunit) isofor...
522.0 [0..7] [574..20]
DPOA2_RAT - DNA polymerase alpha subunit B OS=Rattus norvegicus GN=Pola2 PE=1 SV=2
522.0 [0..7] [574..20]
gi|123982416, gi... - gi|123997079|gb|ABM86141.1| polymerase (DNA directed), alpha 2 (70kD subunit) [synthetic construct],...
POLA2 - polymerase (DNA directed), alpha 2 (70kD subunit)
521.0 [0..7] [574..20]

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Predicted Domain #1
Region A:
Residues: [1-217]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEFPIDDEEL LDERNKLLQI CNMDEQTMFY KWESWCLQRG NTPKLDLDTF KAFAKDMKFQ  60
   61 MERQVKATLK QNPERKSIKQ IPGMNIDSIL GLPVKTTASG DSLMQESKPS TETFELNSSD 120
  121 AGRVLEVLNK ELKIVTSKPS APSKLVIVAN FDLKAFNYRI MYQKLYDSSE VLDDRIELFS 180
  181 ALTCRKYNIS DEDLANPSEL TQEPVVVVGR IVVESTN

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 93.823909
Match: PF08418.1
Description: No description for PF08418.1 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [218-284]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LGGRLNQNSI LLESSRRLGA GVRVRLKVDD LPSYSIFPGQ IVSVKGSNPS GNMFIAKEIL  60
   61 PIPPLPF

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [285-574]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PSSSKQEHAT FVANTNNQPI SIYIASGPWS LRDDLSFSPL KSMISYVNKN PVDLVILCGP  60
   61 FLDINHILIR TGNITGTSAT SLEELFKERV TPILSQLTCP CILIPHINDA ASDHPAWPQD 120
  121 AFNRVALGLP SNFKCFPNPC MFSINDVVFG VSTNDILLHT SREELFRLPS HGNLFARLVS 180
  181 HVLHQRHFYP LFPGGSLEKC NPSNLDIAHL KLGEFLNTMP DILILPSDLR YFVKNVENVV 240
  241 SLNPGKATKG INLGTFAKLT IAPLELGDNG SSNHYSHRVW LRTKAEILKL 

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.52
Match: 1su1A
Description: Structural and biochemical characterization of Yfce, a phosphoesterase from E. coli
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.06438091629012 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 1.87325132707337 bayes_pls_golite062009
catalytic activity 1.30037658165549 bayes_pls_golite062009
protein serine/threonine phosphatase activity 1.17916462117542 bayes_pls_golite062009
phosphoric ester hydrolase activity 0.950264524479969 bayes_pls_golite062009
phosphatase activity 0.829761417192212 bayes_pls_golite062009
phosphoprotein phosphatase activity 0.768201004870964 bayes_pls_golite062009
structural molecule activity 0.211411396269789 bayes_pls_golite062009
hydrolase activity 0.070797330694107 bayes_pls_golite062009
protein binding 0.0115800495687428 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle