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Protein Overview: POLA2

General Information:
Name(s) found: POLA2 [HGNC (HUGO)]
Description(s) found:
Found 32 descriptions.
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  • polymerase (DNA directed), alpha 2 (70kD subunit) [HGNC (HUGO)]
    • Organism: Homo sapiens
    Length: 598 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSASAQQLAE ELQIFGLDCE EALIEKLVEL CVQYGQNEEG MVGELIAFCT STHKVGLTSE  60
   61 ILNSFEHEFL SKRLSKARHS TCKDSGHAGA RDIVSIQELI EVEEEEEILL NSYTTPSKGS 120
  121 QKRAISTPET PLTKRSVSTR SPHQLLSPSS FSPSATPSQK YNSRSNRGEV VTSFGLAQGV 180
  181 SWSGRGGAGN ISLKVLGCPE ALTGSYKSMF QKLPDIREVL TCKIEELGSE LKEHYKIEAF 240
  241 TPLLAPAQEP VTLLGQIGCD SNGKLNNKSV ILEGDREHSS GAQIPVDLSE LKEYSLFPGQ 300
  301 VVIMEGINTT GRKLVATKLY EGVPLPFYQP TEEDADFEQS MVLVACGPYT TSDSITYDPL 360
  361 LDLIAVINHD RPDVCILFGP FLDAKHEQVE NCLLTSPFED IFKQCLRTII EGTRSSGSHL 420
  421 VFVPSLRDVH HEPVYPQPPF SYSDLSREDK KQVQFVSEPC SLSINGVIFG LTSTDLLFHL 480
  481 GAEEISSSSG TSDRFSRILK HILTQRSYYP LYPPQEDMAI DYESFYVYAQ LPVTPDVLII 540
  541 PSELRYFVKD VLGCVCVNPG RLTKGQVGGT FARLYLRRPA ADGAERQSPC IAVQVVRI

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..114] MSA 1.055994 View MSA. No confident structure predictions are available.
    2 View Details [115..215] MSA 1.135995 View MSA. No confident structure predictions are available.
    3 View Details [216..337] deduced N/A Confident ab initio structure predictions are available.
    4 View Details [338..598] PSI-BLAST 7.0 No description for 2dxlA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • hydrolase activity
    		•  2.15398287574737 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  2.11518948144723 bayes_pls_golite062009
  • protein serine/threonine phosphatase activity
    		•  1.72108778738758 bayes_pls_golite062009
  • catalytic activity
    		•  1.39852585255405 bayes_pls_golite062009
  • phosphoprotein phosphatase activity
    		•  1.23036240099336 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  0.899406797746366 bayes_pls_golite062009
  • binding
    		•  0.852545739165539 bayes_pls_golite062009
  • phosphatase activity
    		•  0.76188635342041 bayes_pls_golite062009
  • transporter activity
    		•  0.72444760979153 bayes_pls_golite062009
  • protein binding
    		•  0.682314750442084 bayes_pls_golite062009
  • structural molecule activity
    		•  0.204234628453541 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.169394141800139 bayes_pls_golite062009
  • protein transporter activity
    		•  0.10469955758282 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle