YRC Public Data Repository - Protein Structure Prediction

Protein:	cwg2
Organism:	Schizosaccharomyces pombe
Length:	355 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for cwg2.

Description	E-value	Query Range	Subject Range
gi\|34148075 - gi\|34148075\|gb\|AAQ62584.1\| putative Rab geranylgeranyl transferase type II beta subunit [Glycine max...	369.0	[0..2]	[346..3]
gi\|73960159 - gi\|73960159\|ref\|XP_855504.1\| PREDICTED: similar to Rab geranylgeranyltransferase, beta subunit [Cani...	367.0	[0..2]	[345..172]
gi\|1552549 - gi\|1552549\|emb\|CAA69383.1\| rab geranylgeranyl transferase [Homo sapiens]	366.0	[0..2]	[345..17]
gi\|147900123, gi... - gi\|58833394\|gb\|AAH90236.1\| MGC85147 protein [Xenopus laevis], gi\|147900123\|ref\|NP_001089291.1\| hypot...	366.0	[0..2]	[345..17]
gi\|50751774 - gi\|50751774\|ref\|XP_422548.1\| PREDICTED: similar to Rab geranylgeranyltransferase, beta subunit [Gall...	364.0	[0..2]	[345..135]
gi\|66911331, gi\|... - gi\|76253908\|ref\|NP_998277.2\| RAB geranylgeranyltransferase, beta subunit [Danio rerio], gi\|66911331\|...	362.0	[0..2]	[345..17]
gi\|385477 - gi\|385477\|gb\|AAB27019.1\| Rab geranylgeranyl transferase component B beta subunit; Rab GG transferase... PGTB2_RAT - Geranylgeranyl transferase type-2 subunit beta OS=Rattus norvegicus GN=Rabggtb PE=1 SV=1	361.0	[0..2]	[345..17]
PGTB2_BOVIN - Geranylgeranyl transferase type-2 subunit beta OS=Bos taurus GN=RABGGTB PE=2 SV=1	361.0	[0..2]	[345..17]

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Predicted Domain #1

Region A:
Residues: [1-355]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MELTRAKHIA FFKRHLILFP TPYEEHDCER TVLAFFCLLG LDLLNALNTI DDDDKKSWIE  60
   61 WIYKNYVTKE SKGIKYSGFQ AYRTGIQPIS FEQEPQLAGT VFSICCLLFL GDNLSRIDRD 120
  121 LIKNFVELCK TSQGHFRSIA VPSCSDQDMR QLYMATTIAS LLDFSLSDPL CSIQYIKSCQ 180
  181 RYEGGFSLLP YGEAHAGATF CALASWSLIL KMIPNSSLNT SNQSYNLMDC VPKVERLIRW 240
  241 LASRQLSSGG LNGRTNKDVD TCYAYWVLSS LKLLDALPFI DGGELEKYLL LHAQHALGGF 300
  301 SKTPGEFPDV LHSALGLYAM AYQDDKSFPK VNADIHMTSK YINICRDCIQ AAKGK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	95.39794
Match:	1n4pB
Description:	Protein Geranylgeranyltransferase type-I Complexed with Geranylgeranyl Diphosphate
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
protein geranylgeranyltransferase activity	12.5056881810294	bayes_pls_golite062009
prenyltransferase activity	11.2095419035102	bayes_pls_golite062009
CAAX-protein geranylgeranyltransferase activity	10.5569796788906	bayes_pls_golite062009
protein prenyltransferase activity	8.21177558804895	bayes_pls_golite062009
Rab geranylgeranyltransferase activity	6.2955313775009	bayes_pls_golite062009
protein farnesyltransferase activity	4.15546866363415	bayes_pls_golite062009
binding	1.68564752993879	bayes_pls_golite062009
protein binding	1.45455287827127	bayes_pls_golite062009
transferase activity	1.0950430724883	bayes_pls_golite062009
enzyme regulator activity	0.854896924803117	bayes_pls_golite062009
catalytic activity	0.497699107100544	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: