YRC Public Data Repository - Protein Structure Prediction

Protein:	meu7
Organism:	Schizosaccharomyces pombe
Length:	774 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for meu7.

Description	E-value	Query Range	Subject Range
gi\|56419238, gi\|... - gi\|56419238\|ref\|YP_146556.1\| alpha-cyclodextrinase [Geobacillus kaustophilus HTA426], gi\|56379080\|db...	309.0	[0..142]	[716..6]
gi\|21954508 - gi\|21954508\|dbj\|BAC06336.1\| alpha-amylase [Drosophila punjabiensis]	308.0	[0..288]	[731..31]
AMY2_DROAN - Alpha-amylase 2 OS=Drosophila ananassae GN=Amy58 PE=3 SV=1	307.0	[0..276]	[731..19]
gi\|21954514 - gi\|21954514\|dbj\|BAC06339.1\| alpha-amylase [Drosophila watanabei]	307.0	[0..288]	[731..31]
gi\|15375096 - gi\|15375096\|dbj\|BAB63955.1\| alpha-cyclodextrinase [Geobacillus stearothermophilus]	307.0	[0..142]	[716..6]
gi\|7766933, gi\|7... - gi\|7766933\|pdb\|1SMA\|B Chain B, Crystal Structure Of A Maltogenic Amylase, gi\|7766932\|pdb\|1SMA\|A Chai... gi\|3089607 - gi\|3089607\|gb\|AAC15072.1\| maltogenic amylase [Thermus sp. IM6501]	307.0	[0..189]	[716..45]
gi\|21954502 - gi\|21954502\|dbj\|BAC06333.1\| alpha-amylase [Drosophila nagarholensis]	306.0	[0..288]	[731..31]
gi\|22129791 - gi\|22129791\|gb\|AAL62457.2\| alpha-cyclodextrinase [Thermus sp. YBJ-1]	306.0	[0..142]	[716..6]

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Predicted Domain #1

Region A:
Residues: [1-213]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKLSLKDLAL SIILVLGVAP PVQALSAEEW KKQSVYNVMT DRFATSKVVP HCDVKAEKYC  60
   61 GGNWQGIVDH LDYIRDLGFT AISISPVVEQ LEGPEYHGEA YHGHRPKNYY RLNPHFGNEE 120
  121 DLKELSDALH GKGMYLMVDV AINHTISEYF EDDYFKNTYF DKTHIDHKCK EHCSCHHDKF 180
  181 PRPVPHNGTK PDHKPWKHEE HCHHGKFPRP VPH

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	24.39794
Match:	2bhuA
Description:	Crystal structure of Deinococcus radiodurans maltooligosyltrehalose trehalohydrolase
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [214-656]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NGTKPDHKPW KHEEHCSCHH DKFPRPVPHN GTKPDHKPWK HEEHCSCHHD KFPRPVPHNG  60
   61 TKPDHKPWKH EEHCHHGKFP RPIPHNGTKP DHKPWKHEEH CHHGRFPRPV PHNGTKPDHK 120
  121 PWKHEEHCSC HHDKFSRPVP HNGTKPDHKP WKHEEHCHHG KFLRPVPHNV TKPDHKPWKH 180
  181 EEHCHHGKFP RPVPHNGTKP DHKPWKHEEH CSCHEDHSVH ERPSAKGALE DYIQTFVETF 240
  241 QIDGIRFDAM GDKYRKYWPD FCKAAGVFCM GDLKSSDSLK VCDWQNDLEG LSNFPVRESA 300
  301 VKAFLMNNPE GIVDLADKMT DMRGLCVNPL LLGNFVENKD LPRMASISSD PATLKNAIAF 360
  361 VLMGDGIPMM YNGQELAMRG EEVPYNRPAI WEKGFPKRNP YYKFTSTINR FRKAMIESKD 420
  421 GEAFLNMQSD ISIVDKRILL LRR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	37.522879
Match:	1ehaA
Description:	Glycosyltrehalose trehalohydrolase, N-terminal domain N; Glycosyltrehalose trehalohydrolase; Glycosyltrehalose trehalohydrolase, central domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
hydrolase activity, hydrolyzing O-glycosyl compounds	4.55801959095491	bayes_pls_golite062009
hydrolase activity, acting on glycosyl bonds	4.29108420555514	bayes_pls_golite062009
hydrolase activity	3.17512055043757	bayes_pls_golite062009
alpha-amylase activity	2.09193270404736	bayes_pls_golite062009
amylase activity	2.03484942782894	bayes_pls_golite062009
chitinase activity	1.947859226275	bayes_pls_golite062009
glucosidase activity	1.92306554001182	bayes_pls_golite062009
catalytic activity	1.85569074294201	bayes_pls_golite062009
hexosaminidase activity	0.763360027922833	bayes_pls_golite062009
binding	0.652565277376985	bayes_pls_golite062009
alpha-glucosidase activity	0.502835520523619	bayes_pls_golite062009
alpha-1,3-glucan synthase activity	0.434118980237671	bayes_pls_golite062009
beta-N-acetylhexosaminidase activity	0.369121784919131	bayes_pls_golite062009
voltage-gated potassium channel activity	0.360261932572219	bayes_pls_golite062009
potassium channel activity	0.358830386244838	bayes_pls_golite062009
voltage-gated cation channel activity	0.314720051147256	bayes_pls_golite062009
carbohydrate binding	0.28185708488534	bayes_pls_golite062009
transferase activity, transferring hexosyl groups	0.266938437560648	bayes_pls_golite062009
cytoskeletal protein binding	0.24498703916422	bayes_pls_golite062009
voltage-gated channel activity	0.2331443986638	bayes_pls_golite062009
voltage-gated ion channel activity	0.22617857134269	bayes_pls_golite062009
actin binding	0.15943777627145	bayes_pls_golite062009
hyalurononglucosaminidase activity	0.106703520931481	bayes_pls_golite062009
cation channel activity	0.0935274704472748	bayes_pls_golite062009
gated channel activity	0.00538745205368807	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [657-774]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GKVITVLNNL GSYYIHFHYT VSAEEHKWMD VLSCKSVPVQ DNRQVFMVRN GEPMILYPEE  60
   61 SAYEMGLCPS PIQLTEDYNS EGSLSINVEE AQTSKAPEQN RGFTNVLAAL LLSLLMIL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	72.39794
Match:	2guyA
Description:	No description for 2guyA was found.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: