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View Structure Prediction Details

Protein: GS-PE, CG32495-P...
Organism: Drosophila melanogaster
Length: 491 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GS-PE, CG32495-P....

Description E-value Query
Range
Subject
Range
gi|157120880, gi... - gi|157120880|ref|XP_001653706.1| glutathione synthetase [Aedes aegypti], gi|108874787|gb|EAT39012.1|...
739.0 [0..6] [483..5]

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Predicted Domain #1
Region A:
Residues: [1-491]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSDANTAVL RNCIRLPLAE DELLEVTAKA KDYAIMHGAA MRSKTAFSPD SLNFAPFVLV  60
   61 PSSFPRKEFE KAVALQPIIN RLMHNVAHDE EFITTTLAET IKVDEFTANL FNIYRKVLAH 120
  121 GFTQAYSIGL LRSDYMAHVS EGCAIKQVEI NTVASSFAGI ATQLVPQQKF VLSELGHADK 180
  181 LHNMPDNNAL AGLCDGMVKA WDIYAKPQAV ILFIIEDVSY NICDQRFHEF YIRETYPHIK 240
  241 VLRRTLTEVH REGKLGQSKE LLLGSQEVAV IYFRAGYEPG HYHSQADWDA RYLMETSLAI 300
  301 KCPSIHYHLA GTKKVQQALA QPAVLERFIN DPEEIKAVGK IFTGLYSLDD NEAGNASYEM 360
  361 ALRTPERFVL KPQREGGGNN VYGVDIPDAL KRMSRVERSA WILMDLIHPP LTKGYMVRPG 420
  421 GDMPPQIVDM VSELGIFGVV IGDAEHIVHN YQAGHMLRTK LSTANEGGVA AGLGALDSPY 480
  481 LIDSDDEDEQ K

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1000.0
Match: 2hgsA
Description: Eukaryotic glutathione synthetase, substrate-binding domain; Eukaryotic glutathione synthetase ATP-binding domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
glutathione binding 3.43434843798286 bayes_pls_golite062009
ligase activity 3.25077459445999 bayes_pls_golite062009
glutathione synthase activity 3.18460876432532 bayes_pls_golite062009
catalytic activity 2.5009559386228 bayes_pls_golite062009
ligase activity, forming carbon-carbon bonds 1.59015373957506 bayes_pls_golite062009
succinate-CoA ligase activity 1.52785506428706 bayes_pls_golite062009
CoA carboxylase activity 1.44257510787161 bayes_pls_golite062009
ligase activity, forming carbon-sulfur bonds 0.935432886482705 bayes_pls_golite062009
acetyl-CoA carboxylase activity 0.78189952793438 bayes_pls_golite062009
acid-amino acid ligase activity 0.599203164789408 bayes_pls_golite062009
CoA-ligase activity 0.51228075142462 bayes_pls_golite062009
acid-thiol ligase activity 0.448084116680826 bayes_pls_golite062009
binding 0.374385700553659 bayes_pls_golite062009
succinate-CoA ligase (ADP-forming) activity 0.324506681366243 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 0.239594107637156 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle