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View Structure Prediction Details

Protein: Myb-PE, Myb-PA, ...
Organism: Drosophila melanogaster
Length: 657 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Myb-PE, Myb-PA, ....

Description E-value Query
Range
Subject
Range
gi|8277, gi|68886 - gi|8277|emb|CAA29373.1| unnamed protein product [Drosophila melanogaster], pir||TVFFMA transforming ...
439.0 [0..1] [657..1]

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Predicted Domain #1
Region A:
Residues: [1-84]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASASTENGE ELMNYGSNSD SEESEYSENE DTQVCDKDSQ QNSNADSGYP LDSPELQDSK  60
   61 TTGQKGQNKS GKTSIGAVHP NYGF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 40.69897
Match: 1h8aC
Description: v-Myb
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [85-238]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GKRWSKSEDV LLKQLVETHG ENWEIIGPHF KDRLEQQVQQ RWAKVLNPEL IKGPWTRDED  60
   61 DMVIKLVRNF GPKKWTLIAR YLNGRIGKQC RERWHNHLNP NIKKTAWTEK EDEIIYQAHL 120
  121 ELGNQWAKIA KRLPGRTDNA IKNHWNSTMR RKYD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 46.39794
Match: 1h88C
Description: c-Myb, DNA-binding domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.13863038737912 bayes_pls_golite062009
DNA binding 4.66369707598026 bayes_pls_golite062009
nucleic acid binding 4.51452285155271 bayes_pls_golite062009
transcription factor activity 4.06706589695599 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
sequence-specific DNA binding 2.41271657675151 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.26183812259792 bayes_pls_golite062009
transcription repressor activity 1.91962622287073 bayes_pls_golite062009
transcription activator activity 1.77700860354597 bayes_pls_golite062009
transcription factor binding 1.40653841901929 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.14886080629275 bayes_pls_golite062009
cytoskeletal protein binding 1.14048290764066 bayes_pls_golite062009
chromatin binding 1.04132983826241 bayes_pls_golite062009
transcription cofactor activity 0.84983974758882 bayes_pls_golite062009
protein binding 0.830419844171551 bayes_pls_golite062009
DNA-dependent ATPase activity 0.666799964992178 bayes_pls_golite062009
actin binding 0.618026108235131 bayes_pls_golite062009
transcription corepressor activity 0.25931464844298 bayes_pls_golite062009
DNA helicase activity 0.187022204923867 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [239-367]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VERRSVNASG SDLKSSRTHL ITLIKSGGIS KCMNNMQHNK ESGGEAVNKS ENADGASVTA  60
   61 VKGGDLAQES QDDHQKGSNL AHLSMQHLIK LTMPRQTPII LKRTRKHIPE THHQAGCSSS 120
  121 ETFNQEEAA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [368-580]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GNARSRPPSS PVISPIKSLP FSPSHFLKSP CLTTFEDMDL RASTPVTKVY NRVGMEIKKE  60
   61 METSSIETPH KSQLGPRTPT PFKKALAAIG KKRDGRRYEP SSPSSLVEDL AEIIHEEHLS 120
  121 NSLTANNSKM MGAADQNSTL STEYNAQSPP HMKRARKSLL STWSSNHPYN AGSAKRIQPF 180
  181 ETETPSKFLT SPGDILKDTL CSEQDLPFDE GRK

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 5.49485
Match: PF09316.1
Description: No description for PF09316.1 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [581-657]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ENRPFHNRRI NKYRGGLTYD HVIDPKWARV ACGKSRDQMF MEEQAYACLK NLSCISRSLN  60
   61 FEKQKCLVNS FDRFGSL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle