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View Structure Prediction Details

Protein: rdgB-PB, rdgB-PF
Organism: Drosophila melanogaster
Length: 1250 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for rdgB-PB, rdgB-PF.

Description E-value Query
Range
Subject
Range
rdgB-PA, rdgB-PD... - The gene retinal degeneration B is referred to in FlyBase by the symbol Dmel\rdgB (CG11111, FBgn0003...
gi|220954854 - gi|220954854|gb|ACL89970.1| rdgB-PA [synthetic construct]
1571.0 [0..1] [1247..1]

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Predicted Domain #1
Region A:
Residues: [1-282]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLIKEYRIPL PLTVEEYRIA QLYMIAKKSR EESHGEGSGV EIIINEPYKD GPGGNGQYTK  60
   61 KIYHVGNHLP GWIKSLLPKS ALTVEEEAWN AYPYTRTRYT CPFVEKFSLD IETYYYPDNG 120
  121 YQDNVFQLSG SDLRNRIVDV IDIVKDQLWG GDYVKEEDPK HFVSDKTGRG PLAEDWLEEY 180
  181 WREVKGKKQP TPRNMSLMTA YKICRVEFRY WGMQTKLEKF IHDVALRKMM LRAHRQAWAW 240
  241 QDEWFGLTIE DIRELERQTQ LALAKKMGGG EECSDDSVSE PY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 123.0
Match: 1kcmA
Description: Phoshatidylinositol transfer protein, PITP
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
phospholipid transporter activity 5.13837461289632 bayes_pls_golite062009
lipid transporter activity 4.4358073696145 bayes_pls_golite062009
phosphatidylinositol transporter activity 2.88424241201993 bayes_pls_golite062009
transporter activity 2.27726025087174 bayes_pls_golite062009
substrate-specific transporter activity 2.15798050058248 bayes_pls_golite062009
binding 2.03322388415011 bayes_pls_golite062009
sterol binding 1.69869946950041 bayes_pls_golite062009
cholesterol binding 1.2916246557678 bayes_pls_golite062009
transmembrane transporter activity 1.09413284791115 bayes_pls_golite062009
phosphatidylcholine transmembrane transporter activity 1.08589653256802 bayes_pls_golite062009
cholesterol transporter activity 0.971604403704219 bayes_pls_golite062009
sterol transporter activity 0.84702583633369 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.584604660695011 bayes_pls_golite062009
protein binding 0.43929659331502 bayes_pls_golite062009
ion transmembrane transporter activity 0.295257921753146 bayes_pls_golite062009
active transmembrane transporter activity 0.286459038638072 bayes_pls_golite062009
primary active transmembrane transporter activity 0.265156292873733 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 0.256503527440737 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 0.21859262454477 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 0.215063584310921 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 0.214776368903272 bayes_pls_golite062009
lipid binding 0.207466011012419 bayes_pls_golite062009
cation transmembrane transporter activity 0.0954103313829049 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.0415343979510595 bayes_pls_golite062009
catalytic activity 0.0116392906163881 bayes_pls_golite062009
pyrophosphatase activity 0.00274551209125462 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [283-489]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VSTAATAAST TGSERKKSAP AVPPIVTQQP PSAEASSDEE GEEEEDDDED ENDAIGTGVD  60
   61 LSANQGGSAQ RSRSQSIQMA QKGKFGSKGA LHSPVGSAHS FDLQVANWRM ERLEVDSKSN 120
  121 SDEEFFDCLD TNETNSLAKW SSLELLGEGD DSPPPHGGPS SAASVGGRGN SRQEDSIFNQ 180
  181 DFLMRVASER GNKRQLRSSA SVDRSHD

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [490-729]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSPPGSPSTP SCPTTILILV VHAGSVLDAA SELTAKKSDV TTFRGSFEAV MRQHYPSLLT  60
   61 HVTIKMVPCP SICTDALGIL SSLSPYSFDA SPSAADIPNI ADVPIGAIPL LSVASPEFHE 120
  121 TVNKTVAAAN IVYHEFLKSE EGHGFSGQIV MLGDSMGSLL AYEALCRSNG SQPGTASGAS 180
  181 NSGGDAATNI NTHNPLSPRN SRLDDDERFI EADLDAKRLL VAPSPRRRRS SSSSDSRATK 240
  241 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [730-931]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LDFEVCDFFM FGSPLSVVLA ARKLHDAKAA LPRPNCHQVY NLFHPTDPIA SRLEPLLSAR  60
   61 FSILAPVNVP RYAKYPLGNG QPLHLLEVIQ SHPQHFNDGN NLLAGRRLSD ASMQSTISGL 120
  121 IENVSLSTIH ALQNKWWGTK RLDYALYCPE GLSNFPAHAL PHLFHASYWE SPDVIAFILR 180
  181 QIGKFEGIPF VGSNDDKDNA SF

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 92.49485
Match: PF02862.8
Description: No description for PF02862.8 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [932-1250]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HPGQPREKWI KKRTSVKLKN VAANHRANDV IVQEGREQRL NARFMYGPLD MITLHGEKVD  60
   61 VHIMKDPPAG EWTFLSTEVT DKNGRISYSI PDQVSLGYGI YPVKMVVRGD HTSVDCYMAV 120
  121 VPPLTECVVF SIDGSFTASM SVTGRDPKVR AGAVDVCRHW QELGYLLIYI TGRPDMQQQR 180
  181 VVSWLSQHNF PHGLISFADG LSTDPLGHKT AYLNNLVQNH GISITAAYGS SKDISVYTNV 240
  241 GMRTDQIFIV GKVGKKLQSN ATVLSDGYAA HLAGLQAVGG SRPAKGNARM VIPRGCFNLP 300
  301 GQTANPRRRR LHEQATNEN

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.58
Match: 2i33A
Description: No description for 2i33A was found.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle