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View Structure Prediction Details

Protein: FBpp0305870, sdt-PB
Organism: Drosophila melanogaster
Length: 1292 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FBpp0305870, sdt-PB.

Description E-value Query
Range		 Subject
Range
sdt-PE - The gene stardust is referred to in FlyBase by the symbol Dmel\sdt (CG32717, FBgn0243505). It is a p...
 831.0 [0..1] [1292..76]

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Predicted Domain #1
Region A:
Residues: [1-101] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLTMLSVNQD NGPHREMAVD CPDTFIARNK TPPRYPPPRP PQKHKKSTNT TTTTTITALT  60
   61 NNDHANKMLI VAYHSSHQHE QLQQQHPSKT STTTTTIALD V

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [102-272] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ATQNLYNQKQ QNKLEQIENY ENCLQSERNE QHEQQFEQQK QHQATTAMAA TQVAQQQTPS  60
   61 HKLQATLSSD PNGNSNSNNN SHIVGISSSS SSNNSSITDD FLCVVDGLYQ GRKDTASPSS 120
  121 SAFDEVMSKH TLDSFGSIAY RHLHQQHQAT SNGNSSSNTS NTNSNTNSNT N

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [273-539] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SNSNTNGNTS NNTAVSTKTA TVTKTGVSSS NSNSNSLNSS NSSMHTSSSS SGHSSNIASA  60
   61 TSSSSATSSS TVPDDLSLAP PGYEVSQQQQ QQHLVATPVT MLLPPMAKHR ELPVDVPDSF 120
  121 IEMVKTTPRY PPPAHLSSRG SLLSNGSAST AHTTLSSMGV APSPVTATAA AAASASAACA 180
  181 TTAVAAAAVS GVADGDARRV ADELNGNAKP VPPPRDHLRV EKDGRLVNCS PAPQLPDRRA 240
  241 PGNASSGSSG ATTHPLQHQQ IAQIVEP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [540-629] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TLEQLDSIKK YQEQLRRRRE EEERIAQQNE FLRNSLRGSR KLKALQDTAT PGKAVAQQQQ  60
   61 QATLATQVVG VENEAYLPDE DQPQAEQIDG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [630-688] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YGELIAALTR LQNQLSKSGL STLAGRVSAA HSVLASASVA HVLAARTAVL QRRRSRVSG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 3.69897
Match: 1rsoA
Description: Hetero-tetrameric L27 (Lin-2, Lin-7) domain complexes as organization platforms of supra-molecular assemblies
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
nucleobase, nucleoside, nucleotide kinase activity 3.18270433521719 bayes_pls_golite062009
binding 2.4093171025758 bayes_pls_golite062009
nucleotide kinase activity 1.9239399157391 bayes_pls_golite062009
phosphotransferase activity, phosphate group as acceptor 1.84086757311516 bayes_pls_golite062009
guanylate kinase activity 1.80396483614769 bayes_pls_golite062009
protein binding 1.15557714383339 bayes_pls_golite062009
protein domain specific binding 0.683298345987 bayes_pls_golite062009
PDZ domain binding 0.36419975348392 bayes_pls_golite062009
catalytic activity 0.304516551414824 bayes_pls_golite062009

Predicted Domain #6
Region A:
Residues: [689-738] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PLHHSSLGLQ KDIVELLTQS NTAAAIELGN LLTSHEMEGL LLAHDRIANH

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.77
Match: 1zl8B
Description: NMR structure of L27 heterodimer from C. elegans Lin-7 and H. sapiens Lin-2 scaffold proteins
Matching Structure (courtesy of the PDB):

Predicted Domain #7
Region A:
Residues: [739-815] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TDGTPSPTPT PTPAIGAATG STLSSPVAGP KRNLGMVVPP PVVPPPLAQR GAMPLPRGES  60
   61 PPPVPMPPLA TMPMSMP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 5.522879
Match: 1zl8B
Description: NMR structure of L27 heterodimer from C. elegans Lin-7 and H. sapiens Lin-2 scaffold proteins
Matching Structure (courtesy of the PDB):

Predicted Domain #8
Region A:
Residues: [816-928] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VNLPMSACFG TLNDQNDNIR IIQIEKSTEP LGATVRNEGE AVVIGRIVRG GAAEKSGLLH  60
   61 EGDEILEVNG QELRGKTVNE VCALLGAMQG TLTFLIVPAG SPPSVGVMGG TTG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 20.69897
Match: 1va8A
Description: Solution structure of the PDZ domain of Pals1 protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 3.2595117613307 bayes_pls_golite062009
nucleobase, nucleoside, nucleotide kinase activity 3.03529700765506 bayes_pls_golite062009
substrate-specific transporter activity 2.83180079733297 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 2.39826531242265 bayes_pls_golite062009
protein binding 2.35875654816667 bayes_pls_golite062009
nucleotide kinase activity 1.79696347300128 bayes_pls_golite062009
guanylate kinase activity 1.70730560221787 bayes_pls_golite062009
phosphotransferase activity, phosphate group as acceptor 1.69528181005421 bayes_pls_golite062009
cytoskeletal protein binding 1.68920668586004 bayes_pls_golite062009
signal transducer activity 1.51162321843898 bayes_pls_golite062009
molecular transducer activity 1.51162321843898 bayes_pls_golite062009
protein domain specific binding 0.64214865642772 bayes_pls_golite062009
transcription regulator activity 0.387065538161985 bayes_pls_golite062009
receptor binding 0.359972518335054 bayes_pls_golite062009
actin binding 0.13059495339034 bayes_pls_golite062009

Predicted Domain #9
Region A:
Residues: [929-1292] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SQLAGLGGAH RDTAVLHVRA HFDYDPEDDL YIPCRELGIS FQKGDVLHVI SREDPNWWQA  60
   61 YREGEEDQTL AGLIPSQSFQ HQRETMKLAI AEEAGLARSR GKDGSGSKGA TLLCARKGRK 120
  121 KKKKASSEAG YPLYATTAPD ETDPEEILTY EEVALYYPRA THKRPIVLIG PPNIGRHELR 180
  181 QRLMADSERF SAAVPHTSRA RREGEVPGVD YHFITRQAFE ADILARRFVE HGEYEKAYYG 240
  241 TSLEAIRTVV ASGKICVLNL HPQSLKLLRA SDLKPYVVLV APPSLDKLRQ KKLRNGEPFK 300
  301 EEELKDIIAT ARDMEARWGH LFDMIIINND TERAYHQLLA EINSLEREPQ WVPAQWVHNN 360
  361 RDES

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 89.221849
Match: 1jxmA
Description: Psd-95; Guanylate kinase-like domain of Psd-95
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle