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View Structure Prediction Details

Protein: Nf-YC-PA
Organism: Drosophila melanogaster
Length: 601 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Nf-YC-PA.

Description E-value Query
Range
Subject
Range
gi|38788274 - gi|38788274|ref|NP_872579.2| bromodomain PHD finger transcription factor isoform 1 [Homo sapiens]
263.0 [0..24] [524..2032]

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Predicted Domain #1
Region A:
Residues: [1-234]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYATNNGGTN KAPNSNATSM FDNTITVTPI KMELGQAYAK SQNSAAMQRR TPNAVVVTSS  60
   61 STVSSAQQQQ QQQGQQQQQT VPMASLVSNA CTLVNPSMSV TVATTVASGA KEKTTKATRT 120
  121 QVARKPPPTI DNFWPNIVSE VHSIGQVDAK HQVLPLARIK KIMKLDENAK MIAGEAPLLF 180
  181 AKACEYFIQE LTMHAWVHTE ESRRRTLQRS DIAQAIANYD QFDFLIDIVP REEI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 35.045757
Match: 1n1jB
Description: Nuclear transcription factor Y subunit gamma (Nf-Yc2)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 3.27510691458843 bayes_pls_golite062009
DNA binding 2.84801656088633 bayes_pls_golite062009
nucleic acid binding 2.61296736453579 bayes_pls_golite062009
transcription regulator activity 2.30478015157761 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.18120033767195 bayes_pls_golite062009
protein binding 1.07873333188144 bayes_pls_golite062009
transcription factor activity 1.01889555697279 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.378390077792097 bayes_pls_golite062009
transcription factor binding 0.20278000165075 bayes_pls_golite062009
transcription activator activity 0.16305156761639 bayes_pls_golite062009
transcription cofactor activity 0.0427278296123499 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [235-304]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KPSSAQKTKD GSTSSSSGMA GAASSAASTS NTATSNAAAS VAGNATATGN FVASGSTVPA  60
   61 TTAGGLKLDT 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [305-523]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TGATNAAEVL GFSTVNSDIF SAQLQQQQQQ QQQHAAQQQQ QQQQQQHHQA HPQQVQIIQQ  60
   61 GAGGQQLQYF IALPSQQAAQ LVQQPQPAQN HLPINILSTQ QPTQQLILTA GPNGQLTATP 120
  121 APQTTAQQQT ALLQNLAQQQ QQHQQHQQQI QLLQQVVTPT GELTNVPIAI NASHLNLLQR 180
  181 LQMQQQQQQQ QQQQQQQQQQ QQVIIPTQLL TTQQLLQLG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 7.045757
Match: 1m2vB
Description: Sec24
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [524-601]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GAPTVAHQQQ QQQQQHANLT QQSNASAVAS GTPIFINSTM TGAQAAATQA QQQQSAQQQQ  60
   61 AQTISTMSTD RTLTGGFR

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle