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View Structure Prediction Details

Protein: heph-PB, heph-PF...
Organism: Drosophila melanogaster
Length: 608 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for heph-PB, heph-PF....

Description E-value Query
Range		 Subject
Range
heph-PG - The gene hephaestus is referred to in FlyBase by the symbol Dmel\heph (CG31000, FBgn0011224). It is ...
 310.0 [0..1] [608..8]

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Predicted Domain #1
Region A:
Residues: [1-178] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMSCPIPMPM PISSLHKSEF EPVNIGVKRG SDELLSQAAV MAPASDNNNQ DLATKKAKLE  60
   61 PGTVLAGGIA KASKVIHLRN IPNESGEADV IALGIPFGRV TNVLVLKGKN QAFIEMADEI 120
  121 SATSMVSCYT VTPPQMRGRM VYVQFSNHRE LKTDQGHNNS TAHSDYSVQS PASGSPLP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 15.39794
Match: 2ad9A
Description: Solution structure of Polypyrimidine Tract Binding protein RBD1 complexed with CUCUCU RNA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 6.73097473547076 bayes_pls_golite062009
6.62953239642182 bayes_pls_golite062009
mRNA binding 5.29759606920196 bayes_pls_golite062009
nucleic acid binding 3.81920018903278 bayes_pls_golite062009
binding 3.64400841800969 bayes_pls_golite062009
snRNA binding 3.28448936696877 bayes_pls_golite062009
poly-pyrimidine tract binding 3.11990160533699 bayes_pls_golite062009
single-stranded RNA binding 2.93798024346416 bayes_pls_golite062009
U1 snRNA binding 2.26303528058407 bayes_pls_golite062009
structural molecule activity 1.29928829870122 bayes_pls_golite062009
protein binding 1.12215421354121 bayes_pls_golite062009
transcription regulator activity 1.07788694919471 bayes_pls_golite062009
DNA binding 0.978604858165557 bayes_pls_golite062009
mRNA 3'-UTR binding 0.591700155096213 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.425042944899091 bayes_pls_golite062009
transcription factor activity 0.234742017105535 bayes_pls_golite062009
snoRNA binding 0.0568636182001701 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [179-393] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LSAAANATSN NANSSSDSNS AMGILQNTSA VNAGGNTNAA GGPNTVLRVI VESLMYPVSL  60
   61 DILHQIFQRY GKVLKIVTFT KNNSFQALIQ YPDANSAQHA KSLLDGQNIY NGCCTLRIDN 120
  121 SKLTALNVKY NNDKSRDFTN PALPPGEPGV DIMPTAGGLM NTNDLLLIAA RQRPSLSGDK 180
  181 IVNGLGAPGV LPPFALGLGT PLTGGYNNAL PNLAA

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 4.7
Match: 1sjrA
Description: NMR Structure of RRM2 from Human Polypyrimidine Tract Binding Protein Isoform 1 (PTB1)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
6.40066880991253 bayes_pls_golite062009
RNA binding 6.32219487559982 bayes_pls_golite062009
mRNA binding 4.87640532914983 bayes_pls_golite062009
nucleic acid binding 3.55052626921306 bayes_pls_golite062009
binding 3.48033873254013 bayes_pls_golite062009
snRNA binding 2.99850361909067 bayes_pls_golite062009
poly-pyrimidine tract binding 2.7133834347239 bayes_pls_golite062009
single-stranded RNA binding 2.55628738360472 bayes_pls_golite062009
U1 snRNA binding 1.97699928565988 bayes_pls_golite062009
structural molecule activity 1.30816853575581 bayes_pls_golite062009
transcription regulator activity 1.10029555513317 bayes_pls_golite062009
protein binding 1.05805521997665 bayes_pls_golite062009
DNA binding 0.984725930713243 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.423310828232948 bayes_pls_golite062009
transcription factor activity 0.255891228964936 bayes_pls_golite062009
mRNA 3'-UTR binding 0.229644510503376 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [394-608] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FSLANSGALQ TTAPAMRGYS NVLLVSNLNE EMVTPDALFT LFGVYGDVQR VKILYNKKDS  60
   61 ALIQMAEPQQ AYLAMSHLDK LRLWGKPIRV MASKHQAVQL PKEGQPDAGL TRDYSQNPLH 120
  121 RFKKPGSKNY QNIYPPSATL HLSNIPSSCS EDDIKEAFTS NSFEVKAFKF FPKDRKMALL 180
  181 QLLSVEEAVL ALIKMHNHQL SESNHLRVSF SKSNI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 39.30103
Match: 2adcA
Description: Solution structure of Polypyrimidine Tract Binding protein RBD34 complexed with CUCUCU RNA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 6.73097473547076 bayes_pls_golite062009
6.62953239642182 bayes_pls_golite062009
mRNA binding 5.29759606920196 bayes_pls_golite062009
nucleic acid binding 3.81920018903278 bayes_pls_golite062009
binding 3.64400841800969 bayes_pls_golite062009
snRNA binding 3.28448936696877 bayes_pls_golite062009
poly-pyrimidine tract binding 3.11990160533699 bayes_pls_golite062009
single-stranded RNA binding 2.93798024346416 bayes_pls_golite062009
U1 snRNA binding 2.26303528058407 bayes_pls_golite062009
structural molecule activity 1.29928829870122 bayes_pls_golite062009
protein binding 1.12215421354121 bayes_pls_golite062009
transcription regulator activity 1.07788694919471 bayes_pls_golite062009
DNA binding 0.978604858165557 bayes_pls_golite062009
mRNA 3'-UTR binding 0.591700155096213 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.425042944899091 bayes_pls_golite062009
transcription factor activity 0.234742017105535 bayes_pls_golite062009
snoRNA binding 0.0568636182001701 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
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