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View Structure Prediction Details

Protein: eIF2B-alpha-PA
Organism: Drosophila melanogaster
Length: 306 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for eIF2B-alpha-PA.

Description E-value Query
Range
Subject
Range
gi|54637352, gi|... - gi|54637352|gb|EAL26754.1| GA20657 [Drosophila pseudoobscura pseudoobscura], gi|125772661|ref|XP_001...
gi|195159204, gi... - gi|195159204|ref|XP_002020472.1| GL13494 [Drosophila persimilis], gi|194117241|gb|EDW39284.1| GL1349...
gi|125772661|ref... - GA20657-PA [Drosophila pseudoobscura], GA20657 [Drosophila pseudoobscura pseudoobscura]
326.0 [0..1] [306..1]

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Predicted Domain #1
Region A:
Residues: [1-306]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPQITENGQD FDVVKYFLQL LDEDKDLSSG IAAIRTLLMI LEKKQFGTIH ILHTTMREAV  60
   61 AAMRNTDLSI AAIVSAGELF CRFITLSLDD KHMEECRQIM LNRGKIFLTK LLNSRQVIAQ 120
  121 QAQRFITDGC RILTHSRSRV VLKALITASQ NKKSFHVYVT QGGTGNSGEE MVKDLHAAGI 180
  181 DCTLILDSAT GYVMESVDFV LVGAEAVVES GGIINRIGTY TMGLCAREMK KPFYVLAESF 240
  241 KFSRLYPLNQ RDLPNEYKYS RKHLNDVSKV HPLVDYTPPV YITLLFTDLG RLTPSAVSDE 300
  301 LIKLYM

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 86.0
Match: 1t9kA
Description: X-ray crystal structure of aIF-2B alpha subunit-related translation initiation factor [Thermotoga maritima]
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
translation initiation factor activity 10.1099993541596 bayes_pls_golite062009
translation regulator activity 5.74669335554405 bayes_pls_golite062009
nucleic acid binding 2.17718456512191 bayes_pls_golite062009
transcription regulator activity 1.9283980201455 bayes_pls_golite062009
DNA binding 1.55389679363348 bayes_pls_golite062009
binding 1.53908996868286 bayes_pls_golite062009
catalytic activity 1.31732715713197 bayes_pls_golite062009
translation factor activity, nucleic acid binding 1.09424756417577 bayes_pls_golite062009
transcription repressor activity 1.03828732072006 bayes_pls_golite062009
transcription factor activity 0.995059566132783 bayes_pls_golite062009
sugar binding 0.319281682893106 bayes_pls_golite062009
protein binding 0.0293610121675921 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle