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View Structure Prediction Details

Protein: FBpp0312057, Jon...
Organism: Drosophila melanogaster
Length: 265 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FBpp0312057, Jon....

Description E-value Query
Range
Subject
Range
gi|87130885 - gi|87130885|gb|ABD24064.1| intein-trypsinogen fusion protein [synthetic construct]
240.0 [0..26] [261..154]
gi|58257847 - gi|58257847|gb|AAW69366.1| try14 [Macaca mulatta]
238.0 [0..1] [261..1]
gi|2564751, gi|4... - gi|47481110|gb|AAH69476.1| Protease, serine, 3 [Homo sapiens], gi|47479560|gb|AAH69494.1| Protease, ...
238.0 [0..1] [261..1]
gi|57097397 - gi|57097397|ref|XP_532744.1| PREDICTED: similar to trypsinogen 7 isoform 3 [Canis familiaris]
236.0 [0..1] [261..1]
gi|4239965, gi|3... - gi|6755893|ref|NP_035776.1| trypsin 4 [Mus musculus], gi|4239965|dbj|BAA74761.1| pancreatic trypsin ...
236.0 [0..1] [261..1]

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Predicted Domain #1
Region A:
Residues: [1-265]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKLFVFLALA VAAATAVPAP AQKLTPTPIK DIQGRITNGY PAYEGKVPYI VGLLFSGNGN  60
   61 WWCGGSIIGN TWVLTAAHCT NGASGVTINY GASIRTQPQY THWVGSGDII QHHHYNSGNL 120
  121 HNDISLIRTP HVDFWSLVNK VELPSYNDRY QDYAGWWAVA SGWGGTYDGS PLPDWLQSVD 180
  181 VQIISQSDCS RTWSLHDNMI CINTDGGKST CGGDSGGPLV THDGNRLVGV TSFGSAAGCQ 240
  241 SGAPAVFSRV TGYLDWIRDN TGISY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 61.0
Match: 1co7E
Description: Trypsin(ogen)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
peptidase activity 5.91209560688646 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 5.52773635813967 bayes_pls_golite062009
serine hydrolase activity 5.5105092190926 bayes_pls_golite062009
serine-type peptidase activity 5.49703869306079 bayes_pls_golite062009
serine-type endopeptidase activity 5.39623690248556 bayes_pls_golite062009
endopeptidase activity 5.32070018460528 bayes_pls_golite062009
hydrolase activity 4.40346950809697 bayes_pls_golite062009
catalytic activity 1.40927913545237 bayes_pls_golite062009
binding 1.30738106455622 bayes_pls_golite062009
protein binding 1.30414885212044 bayes_pls_golite062009
fucose binding 1.28001086938735 bayes_pls_golite062009
calcium-dependent protein binding 1.10244132298625 bayes_pls_golite062009
heparin binding 1.0321632468756 bayes_pls_golite062009
nucleic acid binding 1.03130756227487 bayes_pls_golite062009
growth factor activity 0.848900101748605 bayes_pls_golite062009
receptor binding 0.79054390509229 bayes_pls_golite062009
glycosaminoglycan binding 0.56945513804111 bayes_pls_golite062009
DNA binding 0.559109234340392 bayes_pls_golite062009
thrombospondin receptor activity 0.126941350425071 bayes_pls_golite062009
polysaccharide binding 0.0828866805581887 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle