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View Structure Prediction Details

Protein: Ice-PA
Organism: Drosophila melanogaster
Length: 339 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Ice-PA.

Description E-value Query
Range
Subject
Range
gi|1929040 - gi|1929040|emb|CAA72937.1| drICE protein [Drosophila melanogaster]
340.0 [0..1] [339..1]

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Predicted Domain #1
Region A:
Residues: [1-339]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDATNNGESA DQVGIRVGNP EQPNDHTDAL GSVGSGGAGS SGLVAGSSHP YGSGAIGQLA  60
   61 NGYSSPSSSY RKNVAKMVTD RHAAEYNMRH KNRGMALIFN HEHFEVPTLK SRAGTNVDCE 120
  121 NLTRVLKQLD FEVTVYKDCR YKDILRTIEY AASQNHSDSD CILVAILSHG EMGYIYAKDT 180
  181 QYKLDNIWSF FTANHCPSLA GKPKLFFIQA CQGDRLDGGV TMQRSQTETD GDSSMSYKIP 240
  241 VHADFLIAYS TVPGFYSWRN TTRGSWFMQS LCAELAANGK RLDILTLLTF VCQRVAVDFE 300
  301 SCTPDTPEMH QQKQIPCITT MLTRILRFSD KQLAPAGRV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 74.69897
Match: 1m72A
Description: Crystal Structure of Caspase-1 from Spodoptera frugiperda
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
peptidase activity 3.24815349282067 bayes_pls_golite062009
protein binding 2.96725373477762 bayes_pls_golite062009
binding 2.91261616137775 bayes_pls_golite062009
hydrolase activity 2.68442077801437 bayes_pls_golite062009
cyclin-dependent protein kinase regulator activity 2.60103365510479 bayes_pls_golite062009
endopeptidase activity 2.49877323830478 bayes_pls_golite062009
cysteine-type peptidase activity 2.37850336421322 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 2.07426831021634 bayes_pls_golite062009
cysteine-type endopeptidase activity 1.82979469421101 bayes_pls_golite062009
cyclin-dependent protein kinase inhibitor activity 1.38256499817012 bayes_pls_golite062009
catalytic activity 1.03907950272772 bayes_pls_golite062009
enzyme regulator activity 0.0737251792690711 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle