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View Structure Prediction Details

Protein: gi|40365347, gi|...
Organism: Drosophila melanogaster
Length: 881 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|40365347, gi|....

Description E-value Query
Range
Subject
Range
gi|114636261 - gi|114636261|ref|XP_001171650.1| PREDICTED: aryl hydrocarbon receptor nuclear translocator-like isof...
375.0 [0..52] [566..1]

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Predicted Domain #1
Region A:
Residues: [1-108]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYADNKRGLD KVTAATPPTH ALQQQQQQQH PHQQQQHLQH VLQLQQQQQQ HLQQQQHHLQ  60
   61 HQMHTHHNFQ QHETSPTVSQ QQHMQQQQPQ TTQQQHATQQ QQQQQQQT

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.17
Match: 1jchA
Description: Ribonuclease domain of colicin E3; Colicin E3 translocation domain; Colicin E3 receptor domain
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [109-191]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AGMFTRFDAN KSTKGASKMR RDLINAEIAN LRDLLPLPQS TRQRLSQLQL MALVCVYVRK  60
   61 ANYFQQVFKR HNAMHHLHHQ TAT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 3.39794
Match: 1an4A
Description: Usf B/HLH domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.38658950816179 bayes_pls_golite062009
DNA binding 5.18654839258297 bayes_pls_golite062009
nucleic acid binding 5.05768805749761 bayes_pls_golite062009
transcription factor activity 4.78039531631248 bayes_pls_golite062009
transcription activator activity 3.87875547821718 bayes_pls_golite062009
binding 3.81829206350975 bayes_pls_golite062009
sequence-specific DNA binding 3.42035985454056 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.39500382187264 bayes_pls_golite062009
protein binding 2.64975291677725 bayes_pls_golite062009
transcription factor binding 2.61163564741984 bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding 2.42306484786159 bayes_pls_golite062009
transcription cofactor activity 1.52770895937238 bayes_pls_golite062009
transcription repressor activity 0.955588849035129 bayes_pls_golite062009
promoter binding 0.8576109846276 bayes_pls_golite062009
transcription corepressor activity 0.801830750183111 bayes_pls_golite062009
protein heterodimerization activity 0.53175615551166 bayes_pls_golite062009
transcription coactivator activity 0.3513586903977 bayes_pls_golite062009
protein dimerization activity 0.20674648626116 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [192-578]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PNIGFSKALS GFLMMLTQNG KLLYISDNAA EYLGHSMEDL LIHGDSVYDI IDKQDHANIQ  60
   61 AELNRNVPPQ PGGSSQASSG GAGGAGGAGD STSSNGSAAG AGGAGGASSL EGEHRMFLCR 120
  121 MNVSRNARRQ MRFGDQKVVL VQGHYLSFLP LCSRNEPVFL ATCTPIAMPE TRECVVQGAT 180
  181 NVFTTIHSMD MKIAHIDKNG EFHLGYDKST LQGTSWYNLI HSDNLTEAQK KHSLIIQSEQ 240
  241 DRSCILLVRM QRSSGEYTWV HVVLQVRDSP DSTQQPVIVC TNQVLNDREA SIMLANSWLY 300
  301 HYYTVQSKIQ FGMPLDSGIR VPPGTPSSGY YSPHSSHPPA TPGGATPNLG IASSFGPHHH 360
  361 PHHSHHPHHH HHHHHPATAY HHHPHMG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 58.0
Match: 1wa9A
Description: Crystal Structure of the PAS repeat region of the Drosophila clock protein PERIOD
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [579-687]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TYGGVYHAKA AIELKEDQPL FCFQEPVDYS QVNSHVNPPN ATSTPNPPIS KSSTPPPPKK  60
   61 RARKLEPLYL HAERSPAAAI TPEPDCYAIH THPAAAYATS SVVSSDASV

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [688-881]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IYATIVPTRP RLPNKSLPPD PADFIEQWNP SPPWSESAQK ASLDSFGSSH ELSPCITTTP  60
   61 PTPTSATPHQ SGLGTTQTIG PAFSFEWMSD PLVPVTYQQW PPTGDHHQHL SQHLSQSQNH 120
  121 QNPLQQQQNE QLLLGQQPHL HQQHQHLALH HGRGEHSLEG ESQGVVVVPP IPISIPIPTA 180
  181 TGHGDAGEPV EDRG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 3.30103
Match: 1m2vB
Description: Sec24
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle