YRC Public Data Repository - Protein Structure Prediction

Protein:	Dak1-PA
Organism:	Drosophila melanogaster
Length:	253 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Dak1-PA.

Description	E-value	Query Range	Subject Range
gi\|25013025 - gi\|25013025\|gb\|AAN71599.1\| RH52725p [Drosophila melanogaster]	211.0	[0..1]	[253..52]
gi\|54638909\|gb\|E... - GA19345-PA [Drosophila pseudoobscura], GA19345 [Drosophila pseudoobscura pseudoobscura] gi\|125776096, gi... - gi\|54638909\|gb\|EAL28311.1\| GA19345 [Drosophila pseudoobscura pseudoobscura], gi\|125776096\|ref\|XP_001...	175.0	[0..1]	[253..1]
gi\|91076054 - gi\|91076054\|ref\|XP_966357.1\| PREDICTED: similar to cytidylate kinase [Tribolium castaneum]	170.0	[0..58]	[250..13]
KAD_METBF - Adenylate kinase OS=Methanosarcina barkeri (strain Fusaro / DSM 804) GN=adk PE=3 SV=1	170.0	[0..65]	[250..2]
KAD_METMA - Adenylate kinase OS=Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / ... KAD_METMA - Adenylate kinase OS=Methanosarcina mazei GN=adk PE=3 SV=1	169.0	[0..65]	[250..2]
KAD_CLOPE - Adenylate kinase OS=Clostridium perfringens GN=adk PE=3 SV=1 KAD_CLOPE - Adenylate kinase OS=Clostridium perfringens (strain 13 / Type A) GN=adk PE=3 SV=1	168.0	[0..63]	[250..2]
KAD_METAC - Adenylate kinase OS=Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) GN=a... KAD_METAC - Adenylate kinase OS=Methanosarcina acetivorans GN=adk PE=3 SV=1	166.0	[0..65]	[250..2]
KAD_CARHZ - Adenylate kinase OS=Carboxydothermus hydrogenoformans (strain ATCC BAA-161 / DSM 6008 / Z-2901) GN=a...	166.0	[0..65]	[250..2]
gi\|169347079, gi... - gi\|169347079\|ref\|ZP_02866021.1\| adenylate kinase [Clostridium perfringens C str. JGS1495], gi\|169296... gi\|182626945, gi... - gi\|182626945\|ref\|ZP_02954678.1\| adenylate kinase [Clostridium perfringens D str. JGS1721], gi\|177907... KAD_CLOP1 - Adenylate kinase OS=Clostridium perfringens (strain ATCC 13124 / DSM 756 / JCM 1290 / NCIMB 6125 / N... gi\|170663256, gi... - gi\|170663256\|gb\|EDT15939.1\| adenylate kinase [Clostridium perfringens E str. JGS1987], gi\|168205213\|... KAD_CLOPS - Adenylate kinase OS=Clostridium perfringens (strain SM101 / Type A) GN=adk PE=3 SV=1 gi\|168211884, gi... - gi\|170710173\|gb\|EDT22355.1\| adenylate kinase [Clostridium perfringens B str. ATCC 3626], gi\|16821188... gi\|168215197, gi... - gi\|170713401\|gb\|EDT25583.1\| adenylate kinase [Clostridium perfringens CPE str. F4969], gi\|168215197\|... gi\|168216652, gi... - gi\|182381130\|gb\|EDT78609.1\| adenylate kinase [Clostridium perfringens NCTC 8239], gi\|168216652\|ref\|Z...	166.0	[0..65]	[250..2]
gi\|52549652 - gi\|52549652\|gb\|AAU83501.1\| adenylate kinase and related kinases [uncultured archaeon GZfos29E12]	166.0	[0..65]	[252..2]

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Predicted Domain #1

Region A:
Residues: [1-87]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MWRALARTTL RAVANDCGSP GVGLAPSALT QHQLRHSKAS NRFITTTSTA PPHNIGIMSV  60
   61 EKPKIVFVLG GPGAGKGTQC SRIVDRF

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	1.41
Match:	2gesA
Description:	No description for 2gesA was found.

Predicted Domain #2

Region A:
Residues: [88-253]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QFTHLSAGDL LREERSREGS EFGNLIEDYI RNGKIVPVEV TCSLLENAMK ASGKSRFLID  60
   61 GFPRNQDNLD GWNRQMSEKV DFQFVLFFDC GEDVCVKRCL GRGQSGSGRT DDNLDSLKKR 120
  121 ISTYNNDSLP IIKFFEGAGQ VKRIDASPDA EEVFGEVEKI FVASGF

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	39.0
Match:	1tevA
Description:	Crystal structure of the human UMP/CMP kinase in open conformation
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
nucleobase, nucleoside, nucleotide kinase activity	5.63633783771436	bayes_pls_golite062009
nucleotide kinase activity	4.87013305162694	bayes_pls_golite062009
phosphotransferase activity, phosphate group as acceptor	4.71956130169341	bayes_pls_golite062009
adenylate kinase activity	3.67594732794865	bayes_pls_golite062009
binding	2.64537357529343	bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism	2.29455092461489	bayes_pls_golite062009
nucleic acid binding	2.11222585187695	bayes_pls_golite062009
DNA binding	1.7904783386531	bayes_pls_golite062009
transcription regulator activity	1.68903321260301	bayes_pls_golite062009
hydrogen ion transmembrane transporter activity	1.39044805677656	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	1.27520023113176	bayes_pls_golite062009
protein binding	1.22129154759482	bayes_pls_golite062009
ion transmembrane transporter activity	1.1237520329736	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	1.03581449013603	bayes_pls_golite062009
catalytic activity	1.00104173493322	bayes_pls_golite062009
guanylate kinase activity	0.98934362137863	bayes_pls_golite062009
cation transmembrane transporter activity	0.940135818362306	bayes_pls_golite062009
structural constituent of ribosome	0.738234102557832	bayes_pls_golite062009
motor activity	0.68122766055454	bayes_pls_golite062009
transcription factor activity	0.603758349693077	bayes_pls_golite062009
purine nucleotide binding	0.569910969126728	bayes_pls_golite062009
purine ribonucleotide binding	0.568840867400671	bayes_pls_golite062009
ribonucleotide binding	0.568779924702229	bayes_pls_golite062009
nucleotide binding	0.564275755355315	bayes_pls_golite062009
CTP synthase activity	0.554689818807922	bayes_pls_golite062009
microtubule motor activity	0.48522137429998	bayes_pls_golite062009
translation regulator activity	0.29096092258568	bayes_pls_golite062009
translation factor activity, nucleic acid binding	0.274994961137851	bayes_pls_golite062009
formate-tetrahydrofolate ligase activity	0.21533099279384	bayes_pls_golite062009
ATP binding	0.1860481660648	bayes_pls_golite062009
adenyl ribonucleotide binding	0.152859582615242	bayes_pls_golite062009
adenyl nucleotide binding	0.138615225841109	bayes_pls_golite062009
helicase activity	0.0775311459068899	bayes_pls_golite062009
structural molecule activity	0.0558641287316701	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: