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View Structure Prediction Details

Protein: HLHm3-PA
Organism: Drosophila melanogaster
Length: 224 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HLHm3-PA.

Description E-value Query
Range
Subject
Range
gi|55715384 - gi|55715384|gb|AAV59180.1| enhancer of split complex m3 protein [Drosophila melanogaster]
141.0 [0..1] [224..1]
gi|55715449 - gi|55715449|gb|AAV59240.1| enhancer of split complex m3 protein [Drosophila simulans]
136.0 [0..1] [224..1]
gi|54638917, gi|... - gi|54638917|gb|EAL28319.1| GA21008 [Drosophila pseudoobscura pseudoobscura], gi|125776122|ref|XP_001...
gi|125776122|ref... - GA21008-PA [Drosophila pseudoobscura], GA21008 [Drosophila pseudoobscura pseudoobscura]
128.0 [0..1] [224..1]
gi|50347109 - gi|50347109|gb|AAT75230.1| aryl hydrocarbon receptor [Mus musculus]
128.0 [0..5] [216..12]
gi|55275963 - gi|55275963|gb|AAV49747.1| aryl hydrocarbon receptor 1 alpha [Xenopus laevis]
125.0 [0..1] [216..6]

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Predicted Domain #1
Region A:
Residues: [1-118]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVMEMSKTYQ YRKVMKPLLE RKRRARINKC LDDLKDLMVE CLQQEGEHVT RLEKADILEL  60
   61 TVDHMRKLKQ RGGLSLQGVV AGVGSPPTST STAHVESFRS GYVHAADQIT QVLLQTQQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 16.522879
Match: 1am9A
Description: SREBP-1a
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.38658950816179 bayes_pls_golite062009
DNA binding 5.18654839258297 bayes_pls_golite062009
nucleic acid binding 5.05768805749761 bayes_pls_golite062009
transcription factor activity 4.78039531631248 bayes_pls_golite062009
binding 3.81829206350975 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.39500382187264 bayes_pls_golite062009
transcription factor binding 2.61163564741984 bayes_pls_golite062009
transcription repressor activity 2.58751248599889 bayes_pls_golite062009
transcription activator activity 2.5495467409976 bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding 2.42306484786159 bayes_pls_golite062009
sequence-specific DNA binding 2.31910036997977 bayes_pls_golite062009
transcription corepressor activity 2.03674713048499 bayes_pls_golite062009
protein binding 1.59929864805879 bayes_pls_golite062009
transcription cofactor activity 1.52770895937238 bayes_pls_golite062009
promoter binding 0.8576109846276 bayes_pls_golite062009
transcription coactivator activity 0.3513586903977 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [119-224]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TDEIGRKIMK FLSTRLIELQ TQLLQQQQQQ QQHQQQQIPQ SSGRLAFPLL GGYGPAAAAA  60
   61 AISYSSFLTS KDELIDVTSV DGNALSETAS VSSQESGASE PVWRPW

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


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Created and Maintained by: Michael Riffle