YRC Public Data Repository - Protein Structure Prediction

Protein:	HLHmbeta-PA
Organism:	Drosophila melanogaster
Length:	195 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HLHmbeta-PA.

Description	E-value	Query Range	Subject Range
gi\|55715305, gi\|... - gi\|8076\|emb\|CAA47432.1\| E(Spl) HLH-Mbeta [Drosophila melanogaster], gi\|55715435\|gb\|AAV59227.1\| enhan...	162.0	[0..1]	[195..1]
gi\|55715448, gi\|... - gi\|55715460\|gb\|AAV59250.1\| enhancer of split mbeta protein [Drosophila simulans], gi\|55715448\|gb\|AAV... gi\|194908161, gi... - gi\|194908161\|ref\|XP_001981718.1\| GG12207 [Drosophila erecta], gi\|190656356\|gb\|EDV53588.1\| GG12207 [D...	160.0	[0..1]	[195..1]
gi\|195504152, gi... - gi\|55714918\|gb\|AAV59024.1\| enhancer of split mbeta protein [Drosophila yakuba], gi\|195504152\|ref\|XP_...	160.0	[0..1]	[195..1]
gi\|125776134, gi... - gi\|54638920\|gb\|EAL28322.1\| GA13073 [Drosophila pseudoobscura pseudoobscura], gi\|125776134\|ref\|XP_001... gi\|194111963, gi... - gi\|195151959\|ref\|XP_002016906.1\| GL22021 [Drosophila persimilis], gi\|194111963\|gb\|EDW34006.1\| GL2202... gi\|54638920\|gb\|E... - GA13073-PA [Drosophila pseudoobscura], GA13073 [Drosophila pseudoobscura pseudoobscura]	151.0	[0..1]	[195..1]
gi\|7228081 - gi\|7228081\|emb\|CAB77017.1\| HLHmbeta protein [Drosophila hydei]	131.0	[0..1]	[195..1]
gi\|1017761 - gi\|1017761\|gb\|AAA79185.1\| hairy1	130.0	[0..3]	[192..24]
gi\|1279398, gi\|1... - gi\|18858799\|ref\|NP_571154.1\| hairy-related 6 [Danio rerio], gi\|1279398\|emb\|CAA65998.1\| HER-6 protein...	123.0	[0..3]	[187..88]

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Predicted Domain #1

Region A:
Residues: [1-77]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVLEMEMSKT YQYRKVMKPM LERKRRARIN KCLDELKDIM VECLTQEGEH ITRLEKADIL  60
   61 ELTVEHMKKL RAQKQLR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	12.045757
Match:	1nkpA
Description:	Myc prot-oncogene protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transcription regulator activity	5.38658950816179	bayes_pls_golite062009
DNA binding	5.18654839258297	bayes_pls_golite062009
nucleic acid binding	5.05768805749761	bayes_pls_golite062009
transcription factor activity	4.78039531631248	bayes_pls_golite062009
binding	3.81829206350975	bayes_pls_golite062009
RNA polymerase II transcription factor activity	3.39500382187264	bayes_pls_golite062009
transcription factor binding	2.61163564741984	bayes_pls_golite062009
transcription repressor activity	2.58751248599889	bayes_pls_golite062009
transcription activator activity	2.5495467409976	bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding	2.42306484786159	bayes_pls_golite062009
sequence-specific DNA binding	2.31910036997977	bayes_pls_golite062009
transcription corepressor activity	2.03674713048499	bayes_pls_golite062009
protein binding	1.59929864805879	bayes_pls_golite062009
transcription cofactor activity	1.52770895937238	bayes_pls_golite062009
promoter binding	0.8576109846276	bayes_pls_golite062009
transcription coactivator activity	0.3513586903977	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [78-195]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LSSVTGGVSP SADPKLSIAE SFRAGYVHAA NEVSKTLAAV PGVSVDLGTQ LMSHLGHRLN  60
   61 YLQVVVPSLP IGVPLQAPVE DQAMVTPPPS ECDSLESGAC SPAPSEASST SGPMWRPW

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: