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View Structure Prediction Details

Protein: CG6015-PA
Organism: Drosophila melanogaster
Length: 576 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CG6015-PA.

Description E-value Query
Range
Subject
Range
gi|186464325, gi... - gi|23128981|ref|ZP_00110817.1| COG2319: FOG: WD40 repeat [Nostoc punctiforme PCC 73102], gi|18668187...
630.0 [0..4] [576..1165]

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Predicted Domain #1
Region A:
Residues: [1-77]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLGLQSYASS SDEESDHADA ATATTNSEPS APIPDHLLPV DKTHSLSKSI AVCAAPTVVP  60
   61 LGASAVPRTL DPTLKEV

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [78-133]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TYNPRYEEMY APVKGPEHPD LTMQQRAPRN TLAGYVEKAH INAFEFENQR RTFHTY

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [134-488]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GYALDPSVDD QADGQSFVGD LQSAYDDNGK TVFEPPKAKK LRKQEKNDNP EDIEGFLGPW  60
   61 GKFENEVSVA KPNEQERAEL DELLSKRHKR GRIPEDKPLE EKSTLHIKDA YDYQGRSYLH 120
  121 APHDLGVNLR SNAPPTKCFL PKAHIHTWSG HNKGISSIRW FPKTAHLLLS GSMDCRVKLW 180
  181 EVYGERRCIR TFSGHRQAIK DIAWNNRGTN FLSASYDRYI KLWDAETGDV VSRFTTRKMP 240
  241 FCVKFHPDNS KQHLFVAGTS DKKIICWDTR SGDIVQEYDR HLGSVSTITF VDDNRRFVTT 300
  301 SDDKSMRIWE WDIPVDMKYI ADPTMHSMPA VTLAPNGKWM ACQSLDNKIV IFSAL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 78.045757
Match: 1vyhC
Description: PAF-AH Holoenzyme: Lis1/Alfa2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
6.67009948605948 bayes_pls_golite062009
histone methyltransferase activity (H3-K4 specific) 4.71992275913384 bayes_pls_golite062009
actin binding 3.86142918698875 bayes_pls_golite062009
RNA binding 3.77273677738815 bayes_pls_golite062009
snoRNA binding 3.28507672512266 bayes_pls_golite062009
GTPase activity 3.23750443966606 bayes_pls_golite062009
cytoskeletal protein binding 3.1056443224755 bayes_pls_golite062009
tubulin binding 2.76945430061825 bayes_pls_golite062009
microtubule binding 2.72684103222924 bayes_pls_golite062009
dynein binding 2.54821997913979 bayes_pls_golite062009
binding 2.42570478946173 bayes_pls_golite062009
protein binding 2.26925404328312 bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity 2.18628561734369 bayes_pls_golite062009
actin filament binding 2.0735069176589 bayes_pls_golite062009
dynactin binding 1.99805820148456 bayes_pls_golite062009
histone methyltransferase activity 1.85632145559025 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 1.53722103498827 bayes_pls_golite062009
structural molecule activity 1.47097979074281 bayes_pls_golite062009
protein methyltransferase activity 1.35170368882651 bayes_pls_golite062009
nucleic acid binding 1.2886835964948 bayes_pls_golite062009
transcription regulator activity 1.25687092973217 bayes_pls_golite062009
transporter activity 1.21549336905926 bayes_pls_golite062009
lysine N-methyltransferase activity 1.15313682561559 bayes_pls_golite062009
protein-lysine N-methyltransferase activity 1.15313682561559 bayes_pls_golite062009
histone-lysine N-methyltransferase activity 1.15313682561559 bayes_pls_golite062009
receptor activity 1.12819778129653 bayes_pls_golite062009
G-protein-coupled receptor binding 1.11754260203517 bayes_pls_golite062009
mRNA binding 1.05053985350578 bayes_pls_golite062009
microtubule plus-end binding 1.01166033978052 bayes_pls_golite062009
myosin binding 0.989691178611801 bayes_pls_golite062009
molecular transducer activity 0.974380908248463 bayes_pls_golite062009
signal transducer activity 0.974380908248463 bayes_pls_golite062009
substrate-specific transporter activity 0.734793983890004 bayes_pls_golite062009
transcription repressor activity 0.702111212042669 bayes_pls_golite062009
histone binding 0.685319917508843 bayes_pls_golite062009
DNA-dependent ATPase activity 0.625780732991652 bayes_pls_golite062009
DNA binding 0.561578774129549 bayes_pls_golite062009
dynein intermediate chain binding 0.443846546939402 bayes_pls_golite062009
DNA polymerase activity 0.428715007921149 bayes_pls_golite062009
transcription factor activity 0.243992994917491 bayes_pls_golite062009
myosin heavy chain kinase activity 0.231534552000461 bayes_pls_golite062009
protein kinase activity 0.229242350006544 bayes_pls_golite062009
DNA helicase activity 0.220747580531792 bayes_pls_golite062009
ligase activity 0.20682813699621 bayes_pls_golite062009
transcription corepressor activity 0.157016319695991 bayes_pls_golite062009
myosin II binding 0.12060669039328 bayes_pls_golite062009
structural constituent of cytoskeleton 0.118975415284669 bayes_pls_golite062009
receptor binding 0.0390635451962911 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.00585398682921312 bayes_pls_golite062009
N-methyltransferase activity 0.00335766408304172 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [489-576]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NRFKMNRKKT FTGHMVSGYA CQLDFSPDMS YLVSGDGDGK CYIWDWKTTK MYKKWQAHDG  60
   61 VCISALWHPH EASKVVTAGW DGQIKYWD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 79.0
Match: 2gnqA
Description: No description for 2gnqA was found.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle